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Analytic Tools for Post-traumatic Epileptogenesis Biomarker Search in Multimodal Dataset of an Animal Model and Human Patients

Dominique Duncan, Giuseppe Barisano, Ryan Cabeen, Farshid Sepehrband, Rachael Garner, Adebayo Braimah, Paul Vespa, Asla Pitkänen, Meng Law, Arthur W. Toga
2018 Frontiers in Neuroinformatics  
A fundamental challenge in discovering biomarkers of epileptogenesis is that this process is likely multifactorial and crosses multiple modalities.  ...  as epileptogenesis, traumatic brain injury (TBI), and conditions of data collection.  ...  ACKNOWLEDGMENTS This research was supported by the National Institute of Neurological Disorders and Stroke (NINDS) of the National Institutes of Health (NIH) under Award Numbers U54NS100064 (EpiBioS4Rx  ... 
doi:10.3389/fninf.2018.00086 pmid:30618695 pmcid:PMC6307529 fatcat:oeack3fiabcolnemaav4uieote

Post-Traumatic Epilepsy and Comorbidities: Advanced Models, Molecular Mechanisms, Biomarkers, and Novel Therapeutic Interventions

Victoria M. Golub, Doodipala Samba Reddy, Charles France
2022 Pharmacological Reviews  
In this article, we describe a critical appraisal of the current state of PTE research with an emphasis on experimental models, molecular mechanisms of post-traumatic epileptogenesis, potential biomarkers  ...  Post-traumatic epileptogenesis is an enduring process by which a normal brain exhibits hypersynchronous excitability after a head injury incident.  ...  Acknowledgments The authors are grateful to the Reddy laboratory staff for its technical assistance in experimental studies.  ... 
doi:10.1124/pharmrev.121.000375 pmid:35302046 pmcid:PMC8973512 fatcat:aoodgnwfurdytcirl253ynvlu4

Peripheral Blood and Salivary Biomarkers of Blood–Brain Barrier Permeability and Neuronal Damage: Clinical and Applied Concepts

Damir Janigro, Damian M. Bailey, Sylvain Lehmann, Jerome Badaut, Robin O'Flynn, Christophe Hirtz, Nicola Marchi
2021 Frontiers in Neurology  
The development of a biomarker toolkit will enable minimally invasive routines for the assessment of brain health in a broad spectrum of clinical, emergency, and sport settings.  ...  Here, we specifically examine the evidence in favor of or against the use of protein biomarkers of NVU damage and BBB permeability in traumatic head injury, including sport (sub)concussive impacts, seizure  ...  NSE was shown as a possible diagnostic salivary biomarker for neuronal damage in patients post stroke (169) .  ... 
doi:10.3389/fneur.2020.577312 pmid:33613412 pmcid:PMC7890078 fatcat:d3gvdplhzjehbafq7rt72zdsg4

Abstracts fromThe 11th Symposium of the International Neurotrauma SocietyMarch 19–23, 2014Budapest, Hungary

2014 Journal of Neurotrauma  
The feasibility of using CPPopt for guiding patient management needs to be tested in the context of a prospective multi-centre study. A-62  ...  The routine use of CPPopt in the management of patients with severe TBI requires an automated methodology for its continuous bedside calculation.  ...  particular vulnerability to post-traumatic epileptogenesis.  ... 
doi:10.1089/neu.2014.9937 fatcat:7ejlswtiajalrffkeizi4n7edu

Table of Contents

2020 2020 IEEE 17th International Symposium on Biomedical Imaging (ISBI)  
MoPbPo-01.7 A Computational Diffusion Mri Framework for Biomarker Discovery in a Rodent Model of Post-Traumatic Epileptogenesis, pp. 1013-1017.  ...  for Reconstruction of Joint K-Q Under- Sampled High Resolution Diffusion MRI, pp. 913-916.  ... 
doi:10.1109/isbi45749.2020.9098467 fatcat:6kxbkb2s5bdc5cmjvxjhotccay

Neurocritical Care Society Virtual 19th Annual Meeting October 26-29, 2021

2021 Neurocritical Care  
However, in a minority of PMSAH, a posterior circulation aneurysm is causative. Out of concern for missing an aneurysm, many institutions pursue exhaustive imaging.  ...  Using the statistically significant features, we created a scoring system. Receiver operating characteristics (ROC) were used to measure accuracy of this model in predicting aneurysmal etiology.  ...  The frequency/topography of MRI biomarkers in both cohorts were assessed.  ... 
doi:10.1007/s12028-021-01352-8 pmid:34665440 pmcid:PMC8525455 fatcat:6k4o23vj4re5vivnkuar7fky5e


2015 Epilepsia  
atrophy in the post-SE model.  ...  post-kainic acid status epilepticus (post-SE) and post-traumatic epilepsy (PTE).  ...  Results: There was a significant longitudinal increase in the mean of T2 values on the side of HA in the infrequent seizures group (p = 0.022).  ... 
doi:10.1111/epi.13241 fatcat:jnz7opo6tnccjcljtelg53ux6u

Consensus Document on European Brain Research

Monica Di Luca, Mary Baker, Renato Corradetti, Helmut Kettenmann, Julien Mendlewicz, Jes Olesen, Ian Ragan, Manfred Westphal
2011 European Journal of Neuroscience  
To setup a platform for discussion, EBC published in 2006 a Consensus Document on European Brain Research, describing needs and achievements of research in Europe and presenting proposals for future research  ...  A recent study conducted by the European Brain Council (EBC) quantified the 'cost and burden' of major brain diseases in Europe, amounting to €386bn per year.  ...  Significance of increased research Intensifying research in molecular imaging will lead to new possibilities for: noninvasive characterisation or phenotyping of patients for early diagnosis of neurodegenerative  ... 
doi:10.1111/j.1460-9568.2010.07596.x pmid:21385235 fatcat:ceg3ebmypbe4jkiyun5cuihahm

17th Quadrennial Meeting of the World Society for Stereotactic and Functional Neurosurgery. Berlin, Germany, June 26-29, 2017: Abstracts

2017 Stereotactic and Functional Neurosurgery  
Modeled lesions were used as seed regions for deterministic tractography on an 842-subject diffusion data template from HCP in order to identify involved connectomic networks.  ...  Several other scales, imaging (PET, MRI), electrophysiological (EEG), and chemical biomarkers were also obtained.  ...  Hemifacial pain and sensory change following occipital neuralgia may be a symptomatic clue in decision of the exploration of GON.  ... 
doi:10.1159/000478281 pmid:28641280 fatcat:ivcbjloukfgiriry65t37fccm4

Consensus document on European brain research

Jes Olesen, Mary G Baker, Tamas Freund, Monica di Luca, Julien Mendlewicz, Ian Ragan, Manfred Westphal
2006 Journal of Neurology, Neurosurgery and Psychiatry  
Brain research received only 8% of the life science budget in the European Commission's Fifth Framework Programme, which represents less than 0.01% of the annual cost of brain disorders for that period  ...  Many of Europe's young researchers are taking up posts in the USA and staying there. Big pharmaceutical companies are fleeing Europe for the USA, taking their drug development programmes with them.  ...  On the genetic side, animal models are crucial for the discovery of new genetic mutations or polymorphisms.  ... 
pmid:16845120 pmcid:PMC3284269 fatcat:dxw5va3hzvdglj67ldql5wj7yu


2010 Epilepsia  
Purpose: To explore the causative role of PCDH19 gene, located at Xq22, in females with epilepsy.  ...  Using electronic documentation with Epivista Ò follow up is ongoing in all patients. Acknowledgments: supported by: Italian Ministry of Health, Fondazi-  ...  Results: We included 10 patients (8 boys) aged 2.1-7.8 (median 3.7) years at the time when LTG was started in comedication. The onset of MAE had been at 1.5-4.3 (median 2.6) years.  ... 
doi:10.1111/j.1528-1167.2010.02658.x pmid:20590792 fatcat:ylmo7rjtqncydkxeudaib77noy

Applications of Radiotracer Imaging Poster Abstracts

2012 Journal of Cerebral Blood Flow and Metabolism  
Alzheimer's disease (AD) with early onset often presents with a distinct cognitive profile, potentially reflecting a different distribution of underlying neuropathology.  ...  Regional distributions of [ 11 C]PIB and [ 18 F]FDG (both p for interaction < 0.05) differed between groups, however, largely due to increased [ 11 C]PIB binding and decreased [ 18 F]FDG uptake in the  ...  (BCG-DTH)) and in a pattern II MS-like lesion (ie, an antibody-mediated focal fMOG-EAE) rodent model of MS.  ... 
doi:10.1038/jcbfm.2012.78 fatcat:2uvqdqlwsfgexhr5qno2gjfmqe

BNA Festival of Neuroscience 2019

2019 Brain and Neuroscience Advances  
A subgroup (N=487) with extreme levels of stress in both groups was also considered.  ...  An n of 6 will be used for experiments.  ...  Introduction: Post-traumatic stress (PTSD) is associated with altered pubertal timing in humans. Predator odour is a classical rodent PTSD model.  ... 
doi:10.1177/2398212819855490 fatcat:y4b5r7rpdnblzoxvb2crpzqhee

30th Annual Computational Neuroscience Meeting: CNS*2021–Meeting Abstracts

2021 Journal of Computational Neuroscience  
One of the goals of neuroscience is to understand the computational principles that describe the formation of behaviorally relevant signals in the brain, as well as how these computations are realized  ...  Currently, most functional models of neural activity are based on firing rates, while the most relevant signals for inter-neuron communication are spikes.  ...  Here we extended the previous model with a detailed granular layer model (Cichon & Gan, 2015 Apr) to apply input to MFs.  ... 
doi:10.1007/s10827-021-00801-9 pmid:34931275 pmcid:PMC8687879 fatcat:evpmmfpaivgpxdqpive5xdgmwu

45th Annual Congress of the Canadian Neurological Sciences Federation

2010 Canadian Journal of Neurological Sciences  
This study aimed to characterize pathological hippocampal changes underlying epileptogenesis in a rodent model of hyperthermic seizure (HS).  ...  These abnormalities might underlie the epileptogenesis process in this animal model.  ...  Self-management support is a key component of the Ontario Chronic Disease Prevention management (CDPm) framework.  ... 
doi:10.1017/s0317167100010982 fatcat:ks5qxpp2zzckrggkmd3upj2nuu
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