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A compositional process control model and its application to biochemical processes

Catholijn M. Jonker, Andjan Treur
2002 Applied Artificial Intelligence  
A compositional generic process control model is presented which has been applied to control enzymatic biochemical processes.  ...  It integrates qualitative and quantitative techniques. Its application to enzymatic chemical processes is described.  ...  Acknowledgements The authors have learned a lot on process control of enzymatic reactions from the domain expert Carla van Wees (Technical University Delft and Lonsa, Switserland).  ... 
doi:10.1080/088395102753365799 fatcat:f6rnkalp4zcndpnkjkltmnuyna

A Compositional Process Control Model and Its Application to Biochemical Processes [chapter]

Catholijn M. Jonker, Jan Treur
1999 Lecture Notes in Computer Science  
A compositional generic process control model is presented which has been applied to control enzymatic biochemical processes.  ...  It integrates qualitative and quantitative techniques. Its application to enzymatic chemical processes is described.  ...  Acknowledgements The authors have learned a lot on process control of enzymatic reactions from the domain expert Carla van Wees (Technical University Delft and Lonsa, Switserland).  ... 
doi:10.1007/978-3-540-48765-4_33 fatcat:jl54j3drnbcnhf4lj3vpxi2nfm

Nanocomposite Materials with Oriented Functionalized Structure [chapter]

Petrisor Zamora, Nicoleta Petrea, Rodica Mihaela, Razvan Petre, Ciprian Sau, Ioan Saft
2011 Nanomaterials  
The structural and functional modelling of composites depends on the type of application and functions that the composite must carry out.  ...  T h e g l u t a r a l d e h y d e i s t h e m o s t p r o p e r c o m p o u n d t o b e u s e d i n m a c r o m o l e c u l a r functionalizing processes, as it can easily form stable functional structures  ...  that the compositing processes of the different structural components would be carried out in a controlled manner and in distinct stages.  ... 
doi:10.5772/33104 fatcat:ytggtz5iabanliwtfx4n3tgr44

Instrumentation and control of anaerobic digestion processes: a review and some research challenges

Julie Jimenez, Eric Latrille, Jérôme Harmand, Angel Robles, José Ferrer, Daniel Gaida, Christian Wolf, Francis Mairet, Olivier Bernard, Victor Alcaraz-Gonzalez, Hugo Mendez-Acosta, Daniel Zitomer (+12 others)
2015 Reviews in Environmental Science and Biotechnology  
Over the years, research on these topics has evolved and 33 followed the main fields of application of anaerobic digestion processes: from municipal sewage sludge to liquid 34 -mainly industrial -then  ...  31 To enhance energy production from methane or resource recovery from digestate, anaerobic digestion processes 32 require advanced instrumentation and control tools.  ...  composite 767 process model.  ... 
doi:10.1007/s11157-015-9382-6 fatcat:2jasoxrdhjbejjfxcdiacthpq4

Limitations of conventional models and a conceptual framework for a nutrient flow representation of energy utilization by animals

Stephen Birkett, Kees de Lange
2001 British Journal of Nutrition  
A conceptual framework is described for a new model of energy utilization by animals, based on representing explicit flows of the main nutrients and the important biochemical and biological transformations  ...  Variation in the marginal efficiency of utilizing energy can be attributed to various factors: diet nutrient composition; animal effects on diet ME content; diet and animal effects on ME for maintenance  ...  The authors would like to thank Paul Moughan, Martin Verstegen, Patrick Morel and Bruno Marty for their contributions to the development of the concepts.  ... 
doi:10.1079/bjn2001441 pmid:11749675 fatcat:3afsamrnendbvfrrbtt7s2bjpu

Integration of SABIO-RK in workbenches for kinetic model design

Martin Golebiewski, Saqib Mir, Renate Kania, Olga Krebs, Andreas Weidemann, Ulrike Wittig, Isabel Rojas
2007 BMC Systems Biology  
The existence of a programmatic interface, together with the use of controlled vocabularies, ontologies and links to external resources make SABIO-RK well suited for its integration into different applications  ...  For example, parameter units have to be specified in scaled and composite SBML units, and kinetic law equations need to be described in a defined format.  ...  The existence of a programmatic interface, together with the use of controlled vocabularies, ontologies and links to external resources make SABIO-RK well suited for its integration into different applications  ... 
doi:10.1186/1752-0509-1-s1-p4 fatcat:cfr4f2h3vfapled6fubhmlrsd4

Using Matlab and Simulink for High – Level Modeling in Biosystems [chapter]

Cristina-Maria Dabu
2014 MATLAB Applications for the Practical Engineer  
High-Level modeling of biological systems allows a better understanding of informational workflows, a deeper understanding of control and regulatory mechanisms generated by the biochemical processes involved  ...  Control systems theory and high level modeling in biosystems There are a multitude of worldwide databases that store information about signaling pathways and factors involved in biochemical processes,  ... 
doi:10.5772/58369 fatcat:zw2jzqx725ellc2uzrma577ee4

How Important is the Quality of Organic Amendments in Relation to Mineral N Availability in Soils?

M. Mohanty, Nishant K. Sinha, K. Sammi Reddy, R. S. Chaudhary, A. Subba Rao, R. C. Dalal, N. W. Menzies
2013 Agricultural Research  
A decline in SOM can represent a serious threat to soil fertility and quality.  ...  Wastes generated from municipal and agricultural activities have the tremendous potential for application in agriculture as a source of nutrients and as amendments to improve soil organic matter (SOM).  ...  These models were first to combine C/N and related sub processes of a soil-crop-nutrient system into an integrated model.  ... 
doi:10.1007/s40003-013-0052-z fatcat:qkx4t3ta2benhhl2a75ccjruzq

MODELING THE TWO-STAGE ANAEROBIC DIGESTION OF DOMESTIC WASTEWATER WITH THE DEVELOPMENT OF A MONITORING APPLICATION

M. Vega De Lille, J. Forstner, F. Groß, R. Benning, A. Delgado
2016 Brazilian Journal of Chemical Engineering  
After proper calibration and further validation, the model was able to successfully predict the COD degradation from a varying influent, showing its practical applicability.  ...  A transformation method was then applied to estimate from the domestic wastewater composition the input variables to the ADM1.  ...  Since the diffusion phenomenon occurred at a high rate, the process velocity was assumed to be mainly controlled by the biochemical rates.  ... 
doi:10.1590/0104-6632.20160334s20150150 fatcat:yuwerffuqvbibpghjt7hwgdlvq

System-level modeling and synthesis of flow-based microfluidic biochips

Wajid Hassan Minhass, Paul Pop, Jan Madsen
2011 Proceedings of the 14th international conference on Compilers, architectures and synthesis for embedded systems - CASES '11  
We have developed a topology graph-based model of the biochip architecture, and we have used a sequencing graph to model the biochemical applications.  ...  The focus has been on application modeling and component-level simulation.  ...  Biochemical Application Model We model a biochemical application using a sequencing graph [3] .  ... 
doi:10.1145/2038698.2038733 dblp:conf/cases/MinhassPM11 fatcat:4c3rcff545dvzcgqaguinsbxqq

Towards Biosensing Strategies Based on Biochemical Logic Systems

Vladimir Privman, Evgeny Katz, Joseph Wang
2009 arXiv   pre-print
Here we survey existing enabling research results, as well as ideas and research avenues for future development of a new paradigm of digitally operating biosensors logically processing multiple biochemical  ...  Recent advances in biochemical computing, i.e., information processing with cascades of primarily enzymatic reactions realizing computing gates, such as AND, OR, etc., as well as progress in networking  ...  Thus, biosensors will digitally process multiple biochemical signals according to built-in Boolean logic "programmed" in the biomolecular composition of the systems.  ... 
arXiv:0909.1583v1 fatcat:tx3umhabmbflzhonyyxizocn44

Engineering Three-Dimensional Stem Cell Morphogenesis for the Development of Tissue Models and Scalable Regenerative Therapeutics

Melissa A. Kinney, Tracy A. Hookway, Yun Wang, Todd C. McDevitt
2013 Annals of Biomedical Engineering  
highlight the opportunities to employ stem cell spheroids for tissue modeling, bioprocessing, and regenerative therapies.  ...  Therefore, expansion and differentiation of stem cells as multicellular aggregates provides a controlled platform for studying the biological and engineering principles underlying spatiotemporal morphogenesis  ...  M.A.K. is currently supported by an American Heart Association (AHA) Pre-Doctoral Fellowship and previously by an NSF Graduate Research Fellowship.  ... 
doi:10.1007/s10439-013-0953-9 pmid:24297495 pmcid:PMC3939035 fatcat:hba5cbe3zfg6hmovwrrdqxldp4

Machine learning for biochemical engineering: A review

Max Mowbray, Thomas Savage, Chufan Wu, Ziqi Song, Bovinille Anye Cho, Ehecatl A. Del Rio-Chanona, Dongda Zhang
2021 Biochemical engineering journal  
and stochastic domains common to biochemical engineering.  ...  Finally, core challenges into the application of machine learning in biochemical engineering are thoroughly discussed, and further insight into adoption of innovative hybrid modelling and transfer learning  ...  Model-based RL attempts to model the system and find an optimal policy (e.g. optimal control actions) based on a process model.  ... 
doi:10.1016/j.bej.2021.108054 fatcat:jvbkblcoevghxm4swnormswt64

Solid-state fermentation

Ashok Pandey
2003 Biochemical engineering journal  
Today with better understanding of biochemical engineering aspects, particularly on mathematical modelling and design of bioreactors (fermenters), it is possible to scale up SSF processes and some designs  ...  Utilisation of agro-industrial residues as substrates in SSF processes provides an alternative avenue and value-addition to these otherwise under-or non-utilised residues.  ...  The key to these advances has been the application of mathematical modelling techniques to describe various physicochemical and biochemical phenomena within the system [23] [24] [25] [26] .  ... 
doi:10.1016/s1369-703x(02)00121-3 fatcat:z4qfnttucrgwpmh2nih2g5y3sa

BioMOL: a computer-assisted biological modeling tool for complex chemical mixtures and biological processes at the molecular level

Michael T Klein, Gang Hou, Richard J Quann, Wei Wei, Kai H Liao, Raymond S H Yang, Julie A Campain, Monica A Mazurek, Linda J Broadbelt
2002 Environmental Health Perspectives  
This article is part of the monograph Application of Technology to Chemical Mixture Research.  ...  Even though this modeling approach has enjoyed successful application in the petroleum industry, its application to biomedical research has just begun.  ...  From a different angle, the biological application of reaction network modeling may be pursued with a bottom-up approach such as that we have used with B[a]P and some of its metabolites in the overall  ... 
doi:10.1289/ehp.02110s61025 pmid:12634134 pmcid:PMC1241287 fatcat:vy66q65jg5h5zd2rvvnt5eh4tu
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