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A Competitive-Based Method for Determining the Number of Groups: A Clinical Application
[chapter]
2005
Lecture Notes in Computer Science
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We show how this technology can be used to perform patients diagnosis and follow-up by grouping the results of gait measurement with a competitive neural network where the number of clusters is automatically ...
A proper gait assessment in patients with knee or hip injuries strongly determines the diagnosis and consequently the evolution of the pathology, the quality of life of implanted patients, and the overall ...
., and projects PTR95.0734.OP (PETRI program) and OTRI-PAI-03-18 (Junta de Andalucía and OTRI of the Universidad de Málaga). ...
doi:10.1007/11494669_149
fatcat:ao3ir3iwejbcjdscqirfxhfjyi
Affinity chromatography: a review of clinical applications
1999
Clinical Chemistry
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Some traditional applications of this approach include the use of boronate, lectin, protein A or protein G, and immunoaffinity supports for the direct quantification of solutes. ...
This review describes the basic principles of affinity chromatography and examines its use in the testing of clinical samples, with an emphasis on HPLC-based methods. ...
Liquid chromatographic methods, and especially those based on HPLC, are an important group of techniques in modern clinical laboratories. ...
pmid:10222345
fatcat:ruqf3wpalrbwnkw7ejxwyldwbq
Clinical and Pharmaceutical Applications of Affinity Ligands in Capillary Electrophoresis: A Review
2019
Journal of Pharmaceutical and Biomedical Analysis
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This review will examine several classes of binding agents that have been used in ACE and applications that have been described for the resulting methods in clinical or pharmaceutical analysis. ...
The general principles and formats of ACE for each of these applications will be examined, along with the potential advantages or limitations of these methods. ...
Acknowledgements -This work was supported, in part, by the National Institutes of Health (NIH) under grants R01 DK069629 and R01 GM044931. ...
doi:10.1016/j.jpba.2019.112882
pmid:31542417
pmcid:PMC6873927
fatcat:bqeanrwjyjdrbldqrckljlbgh4
Towards a Clinically Applicable Computational Larynx Model
2019
Applied Sciences
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The reduction in computational time achieved is a promising step towards the clinical application of these computational larynx models in the near future. ...
The enormous computational power and time required for simulating the complex phonation process preclude the effective clinical use of computational larynx models. ...
The funders had no role in the design of the study, in the collection, analyses, or interpretation of data, in the writing of the manuscript, or in the decision to publish the results. ...
doi:10.3390/app9112288
fatcat:ieu4agncyrdw3j53nuvhslqs7u
Clinical application of robotic orthopedic surgery: a bibliometric study
2021
BMC Musculoskeletal Disorders
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Objectives The present study aimed to evaluate the status and trends of robotic orthopedic surgery in a clinical setting using bibliometrics. ...
Methods All relevant publications on the clinical use of robotic surgery in orthopedics were searched from the Web of Science database. Subsequently, data were analyzed using bibliometrics. ...
Acknowledgements Not applicable. ...
doi:10.1186/s12891-021-04714-7
pmid:34809652
pmcid:PMC8609816
fatcat:6mp7qmkxk5g3pb2hqzam6nbcxu
Improving the Quality and Quantity of Clinical and Translational Research Statewide: An Application of Group Concept Mapping
2021
Journal of Clinical and Translational Science
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We implemented a Group Concept Mapping exercise to characterize the views of researchers and administrators regarding how to increase the quality and quantity of clinical and translational research in ...
This method is well suited to translational research enterprises beyond Rhode Island when a participatory evaluation stance is desired. ...
To enhance competitiveness for clinical and translational research (CTR), grants have been awarded to build infrastructure and human resources in the form of pilot project funding, support for biostatistical ...
doi:10.1017/cts.2020.572
pmid:33948289
pmcid:PMC8057434
fatcat:zpwz6qtjhbh43fpdb3ehomutta
Computational psychiatry as a bridge from neuroscience to clinical applications
2016
Nature Neuroscience
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identifying a group of people with a relatively worse outcome that requires intervention, and thereby sanctions the labels disorder or disease. ...
We review advances in both approaches, with an emphasis on clinical applications, and discuss how they can be combined. ...
Subjects were separated into two groups based on only one parameter (the learning rate). ...
doi:10.1038/nn.4238
pmid:26906507
pmcid:PMC5443409
fatcat:6su7zkacd5acblaw2rnynrghvi
Clinical applications of bovine colostrum therapy: a systematic review
2014
Nutrition reviews
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Animal models may help researchers to better understand the mechanisms of bovine colostrum supplementation, the dosage regimens required to obtain clinical benefits, and the optimal methods for testing ...
Bovine colostrum may provide gastrointestinal and immunological benefits, but further studies are required before recommendations can be made for clinical application. ...
This work was funded in part by a research grant from the Danish Child Cancer Foundation and by Odense University Hospital research funds. Declaration of interest. ...
doi:10.1111/nure.12089
pmid:24571383
fatcat:wovy4uw7obgsreaqyh2643jwqm
Augmenting word2vec with latent Dirichlet allocation within a clinical application
[article]
2018
arXiv
pre-print
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Two of our models get F-scores over the current state-of-the-art using automatic methods on the DementiaBank dataset. ...
This paper presents three hybrid models that directly combine latent Dirichlet allocation and word embedding for distinguishing between speakers with and without Alzheimer's disease from transcripts of ...
Acknowledgements The Wisconsin Longitudinal Study is sponsored by the National Institute on Aging (grant numbers R01AG009775, R01AG033285, and R01AG041868), and was conducted by the University of Wisconsin ...
arXiv:1808.03967v1
fatcat:fkucu26oerb6vg3r2tf35zt5um
Application of Chemoproteomics to Drug Discovery: Identification of a Clinical Candidate Targeting Hsp90
2010
Chemistry and Biology
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We thank the following individuals and groups: Allison Cromwell, Michael Hast, and Tim Wadkins for assistance with proteome screening efforts; Klass Hardemann for resin preparation; David Blake and Carl ...
ACKNOWLEDGMENTS All authors are former employees of Serenex Inc. and may benefit financially if SNX-5422 progresses to additional clinical trials. ...
Confirmation of ATP-Competitive Binding Mode Based on both the combined attractiveness of Hsp90 as a target for oncology and the chemical hits emerging from the screen, Hsp90 was selected as a discovery ...
doi:10.1016/j.chembiol.2010.04.015
pmid:20659681
fatcat:q2kspknmjbgz5kijihhsjnvo5e
Leuprolide acetate: a drug of diverse clinical applications
2007
Expert Opinion on Investigational Drugs
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Aside determine the use of leuprolide acetate for the treatment
from the occasional allergic nasal reaction in the naferelin of neurologic disorders.
group, the three GnRH ...
methods of administration, the multi-low dose or the single the Aβ precursor protein (AβPP) towards the amyloidogenic
depot were equally effective; however, based on convenience, ...
doi:10.1517/13543784.16.11.1851
pmid:17970643
fatcat:3kzbjfexxjc4njny3wp3syy3ni
Structural neuroimaging as clinical predictor: A review of machine learning applications
2018
NeuroImage: Clinical
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We specifically address practical problems commonly encountered in the literature, with the aim of helping researchers improve the application of these techniques in future works. ...
Alzheimer's disease (AD), Parkinson's disease (PD), autism, multiple sclerosis, traumatic brain injury, etc.) in order to provide a comprehensive view of the state of the art in different fields. ...
Penelope Kostopoulos for her insightful comments. ...
doi:10.1016/j.nicl.2018.08.019
pmid:30167371
pmcid:PMC6108077
fatcat:mgshyb6herb7hpuwbizdnkcd6m
Chromosome Analysis by Image Processing in a Computerized Environment. Clinical Applications
1992
Journal of Radiation Research
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A specific adaptation to cancer cytogenetics is under development (determination of the modal number, translocations analysis with densitometric curves, automatic identification of markers). ...
Dealing with a routine regional cytogenetic activity, we have developed and adapted to clinical work a semi automatic karyotyping machine. ...
The possible user of a karyotyping system should keep in mind the following questions: are performances data based on routine clinical use? ...
doi:10.1269/jrr.33.supplement_171
pmid:1507168
fatcat:w5223nw4iree3juiqdtxr324aq
An application of business process management in a dental clinic
2020
GEPROS: Gestão da Produção, Operações e Sistemas
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In this context, the objective of this research was to analyze the case of a dental clinic located in a city from the interior of the state of Sao Paulo, Brazil, to understand and define the critical client ...
service and stock management processes, through an application of the Business Process Management (BPM) model. ...
BPM Planning This phase involved the development of a BPM application plan, in order to identify activities that work in partnership with the organizational directives of the clinic. ...
doi:10.15675/gepros.v15i3.2733
fatcat:j276o7jafvbrljcdhra5mrd2hq
Coreference resolution: A review of general methodologies and applications in the clinical domain
2011
Journal of Biomedical Informatics
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Our goal was to review recent advances in general purpose coreference resolution to lay the foundation for methodologies in the clinical domain, facilitated by the availability of a shared lexical resource ...
Coreference resolution is the task of determining linguistic expressions that refer to the same real-world entity in natural language. ...
Acknowledgment The work was funded by Grant R01 CA127979 (The ODIE toolkit-software for Ontology Development and Information Extraction). ...
doi:10.1016/j.jbi.2011.08.006
pmid:21856441
pmcid:PMC3226856
fatcat:3t4j5t4fvvbrjlezjlirx3gz6e
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