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A Competitive-Based Method for Determining the Number of Groups: A Clinical Application [chapter]

Antonio Sánchez, Francisco Vico, Santiago Cabello, Francisco Veredas, Yamina Seamari, Isaac López, Javier Farfán, Guillermo García-Herrera
2005 Lecture Notes in Computer Science  
We show how this technology can be used to perform patients diagnosis and follow-up by grouping the results of gait measurement with a competitive neural network where the number of clusters is automatically  ...  A proper gait assessment in patients with knee or hip injuries strongly determines the diagnosis and consequently the evolution of the pathology, the quality of life of implanted patients, and the overall  ...  ., and projects PTR95.0734.OP (PETRI program) and OTRI-PAI-03-18 (Junta de Andalucía and OTRI of the Universidad de Málaga).  ... 
doi:10.1007/11494669_149 fatcat:ao3ir3iwejbcjdscqirfxhfjyi

Affinity chromatography: a review of clinical applications

D S Hage
1999 Clinical Chemistry  
Some traditional applications of this approach include the use of boronate, lectin, protein A or protein G, and immunoaffinity supports for the direct quantification of solutes.  ...  This review describes the basic principles of affinity chromatography and examines its use in the testing of clinical samples, with an emphasis on HPLC-based methods.  ...  Liquid chromatographic methods, and especially those based on HPLC, are an important group of techniques in modern clinical laboratories.  ... 
pmid:10222345 fatcat:ruqf3wpalrbwnkw7ejxwyldwbq

Clinical and Pharmaceutical Applications of Affinity Ligands in Capillary Electrophoresis: A Review

Chenhua Zhang, Ashley G. Woolfork, Kyungah Suh, Susan Ovbude, Cong Bi, Marawan Elzoeiry, David S. Hage
2019 Journal of Pharmaceutical and Biomedical Analysis  
This review will examine several classes of binding agents that have been used in ACE and applications that have been described for the resulting methods in clinical or pharmaceutical analysis.  ...  The general principles and formats of ACE for each of these applications will be examined, along with the potential advantages or limitations of these methods.  ...  Acknowledgements -This work was supported, in part, by the National Institutes of Health (NIH) under grants R01 DK069629 and R01 GM044931.  ... 
doi:10.1016/j.jpba.2019.112882 pmid:31542417 pmcid:PMC6873927 fatcat:bqeanrwjyjdrbldqrckljlbgh4

Towards a Clinically Applicable Computational Larynx Model

Hossein Sadeghi, Stefan Kniesburges, Sebastian Falk, Manfred Kaltenbacher, Anne Schützenberger, Michael Döllinger
2019 Applied Sciences  
The reduction in computational time achieved is a promising step towards the clinical application of these computational larynx models in the near future.  ...  The enormous computational power and time required for simulating the complex phonation process preclude the effective clinical use of computational larynx models.  ...  The funders had no role in the design of the study, in the collection, analyses, or interpretation of data, in the writing of the manuscript, or in the decision to publish the results.  ... 
doi:10.3390/app9112288 fatcat:ieu4agncyrdw3j53nuvhslqs7u

Clinical application of robotic orthopedic surgery: a bibliometric study

Cheng Li, Lei Wang, Carsten Perka, Andrej Trampuz
2021 BMC Musculoskeletal Disorders  
Objectives The present study aimed to evaluate the status and trends of robotic orthopedic surgery in a clinical setting using bibliometrics.  ...  Methods All relevant publications on the clinical use of robotic surgery in orthopedics were searched from the Web of Science database. Subsequently, data were analyzed using bibliometrics.  ...  Acknowledgements Not applicable.  ... 
doi:10.1186/s12891-021-04714-7 pmid:34809652 pmcid:PMC8609816 fatcat:6mp7qmkxk5g3pb2hqzam6nbcxu

Improving the Quality and Quantity of Clinical and Translational Research Statewide: An Application of Group Concept Mapping

Jacquelyn Fede, Stephen J. Kogut, Anthony Hayward, John F. Stevenson, Cynthia Willey-Temkin, Heather Fournier, Gabrielle Stranieri, Judy A. Kimberly, James Padbury
2021 Journal of Clinical and Translational Science  
We implemented a Group Concept Mapping exercise to characterize the views of researchers and administrators regarding how to increase the quality and quantity of clinical and translational research in  ...  This method is well suited to translational research enterprises beyond Rhode Island when a participatory evaluation stance is desired.  ...  To enhance competitiveness for clinical and translational research (CTR), grants have been awarded to build infrastructure and human resources in the form of pilot project funding, support for biostatistical  ... 
doi:10.1017/cts.2020.572 pmid:33948289 pmcid:PMC8057434 fatcat:zpwz6qtjhbh43fpdb3ehomutta

Computational psychiatry as a bridge from neuroscience to clinical applications

Quentin J M Huys, Tiago V Maia, Michael J Frank
2016 Nature Neuroscience  
identifying a group of people with a relatively worse outcome that requires intervention, and thereby sanctions the labels disorder or disease.  ...  We review advances in both approaches, with an emphasis on clinical applications, and discuss how they can be combined.  ...  Subjects were separated into two groups based on only one parameter (the learning rate).  ... 
doi:10.1038/nn.4238 pmid:26906507 pmcid:PMC5443409 fatcat:6su7zkacd5acblaw2rnynrghvi

Clinical applications of bovine colostrum therapy: a systematic review

Mathias Rathe, Klaus Müller, Per Torp Sangild, Steffen Husby
2014 Nutrition reviews  
Animal models may help researchers to better understand the mechanisms of bovine colostrum supplementation, the dosage regimens required to obtain clinical benefits, and the optimal methods for testing  ...  Bovine colostrum may provide gastrointestinal and immunological benefits, but further studies are required before recommendations can be made for clinical application.  ...  This work was funded in part by a research grant from the Danish Child Cancer Foundation and by Odense University Hospital research funds. Declaration of interest.  ... 
doi:10.1111/nure.12089 pmid:24571383 fatcat:wovy4uw7obgsreaqyh2643jwqm

Augmenting word2vec with latent Dirichlet allocation within a clinical application [article]

Akshay Budhkar, Frank Rudzicz
2018 arXiv   pre-print
Two of our models get F-scores over the current state-of-the-art using automatic methods on the DementiaBank dataset.  ...  This paper presents three hybrid models that directly combine latent Dirichlet allocation and word embedding for distinguishing between speakers with and without Alzheimer's disease from transcripts of  ...  Acknowledgements The Wisconsin Longitudinal Study is sponsored by the National Institute on Aging (grant numbers R01AG009775, R01AG033285, and R01AG041868), and was conducted by the University of Wisconsin  ... 
arXiv:1808.03967v1 fatcat:fkucu26oerb6vg3r2tf35zt5um

Application of Chemoproteomics to Drug Discovery: Identification of a Clinical Candidate Targeting Hsp90

Patrick Fadden, Kenneth H. Huang, James M. Veal, Paul M. Steed, Amy F. Barabasz, Briana Foley, Mei Hu, Jeffrey M. Partridge, John Rice, Anisa Scott, Laura G. Dubois, Tiffany A. Freed (+17 others)
2010 Chemistry and Biology  
We thank the following individuals and groups: Allison Cromwell, Michael Hast, and Tim Wadkins for assistance with proteome screening efforts; Klass Hardemann for resin preparation; David Blake and Carl  ...  ACKNOWLEDGMENTS All authors are former employees of Serenex Inc. and may benefit financially if SNX-5422 progresses to additional clinical trials.  ...  Confirmation of ATP-Competitive Binding Mode Based on both the combined attractiveness of Hsp90 as a target for oncology and the chemical hits emerging from the screen, Hsp90 was selected as a discovery  ... 
doi:10.1016/j.chembiol.2010.04.015 pmid:20659681 fatcat:q2kspknmjbgz5kijihhsjnvo5e

Leuprolide acetate: a drug of diverse clinical applications

Andrea C Wilson, Sivan Vadakkadath Meethal, Richard L Bowen, Craig S Atwood
2007 Expert Opinion on Investigational Drugs  
Aside determine the use of leuprolide acetate for the treatment from the occasional allergic nasal reaction in the naferelin of neurologic disorders. group, the three GnRH  ...  methods of administration, the multi-low dose or the single the Aβ precursor protein (AβPP) towards the amyloidogenic depot were equally effective; however, based on convenience,  ... 
doi:10.1517/13543784.16.11.1851 pmid:17970643 fatcat:3kzbjfexxjc4njny3wp3syy3ni

Structural neuroimaging as clinical predictor: A review of machine learning applications

José María Mateos-Pérez, Mahsa Dadar, María Lacalle-Aurioles, Yasser Iturria-Medina, Yashar Zeighami, Alan C. Evans
2018 NeuroImage: Clinical  
We specifically address practical problems commonly encountered in the literature, with the aim of helping researchers improve the application of these techniques in future works.  ...  Alzheimer's disease (AD), Parkinson's disease (PD), autism, multiple sclerosis, traumatic brain injury, etc.) in order to provide a comprehensive view of the state of the art in different fields.  ...  Penelope Kostopoulos for her insightful comments.  ... 
doi:10.1016/j.nicl.2018.08.019 pmid:30167371 pmcid:PMC6108077 fatcat:mgshyb6herb7hpuwbizdnkcd6m

Chromosome Analysis by Image Processing in a Computerized Environment. Clinical Applications

1992 Journal of Radiation Research  
A specific adaptation to cancer cytogenetics is under development (determination of the modal number, translocations analysis with densitometric curves, automatic identification of markers).  ...  Dealing with a routine regional cytogenetic activity, we have developed and adapted to clinical work a semi automatic karyotyping machine.  ...  The possible user of a karyotyping system should keep in mind the following questions: are performances data based on routine clinical use?  ... 
doi:10.1269/jrr.33.supplement_171 pmid:1507168 fatcat:w5223nw4iree3juiqdtxr324aq

An application of business process management in a dental clinic

Bruna da Silva Garcia, Renato de Campos
2020 GEPROS: Gestão da Produção, Operações e Sistemas  
In this context, the objective of this research was to analyze the case of a dental clinic located in a city from the interior of the state of Sao Paulo, Brazil, to understand and define the critical client  ...  service and stock management processes, through an application of the Business Process Management (BPM) model.  ...  BPM Planning This phase involved the development of a BPM application plan, in order to identify activities that work in partnership with the organizational directives of the clinic.  ... 
doi:10.15675/gepros.v15i3.2733 fatcat:j276o7jafvbrljcdhra5mrd2hq

Coreference resolution: A review of general methodologies and applications in the clinical domain

Jiaping Zheng, Wendy W. Chapman, Rebecca S. Crowley, Guergana K. Savova
2011 Journal of Biomedical Informatics  
Our goal was to review recent advances in general purpose coreference resolution to lay the foundation for methodologies in the clinical domain, facilitated by the availability of a shared lexical resource  ...  Coreference resolution is the task of determining linguistic expressions that refer to the same real-world entity in natural language.  ...  Acknowledgment The work was funded by Grant R01 CA127979 (The ODIE toolkit-software for Ontology Development and Information Extraction).  ... 
doi:10.1016/j.jbi.2011.08.006 pmid:21856441 pmcid:PMC3226856 fatcat:3t4j5t4fvvbrjlezjlirx3gz6e
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