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Suitability of Pharmacokinetic Models for Dynamic Contrast-Enhanced MRI of Abdominal Aortic Aneurysm Vessel Wall: A Comparison

V. Lai Nguyen, M. Eline Kooi, Walter H. Backes, Raf H. M. van Hoof, Anne E. C. M. Saris, Mirthe C. J. Wishaupt, Femke A. M. V. I. Hellenthal, Rob J. van der Geest, Alfons G. H. Kessels, Geert Willem H. Schurink, Tim Leiner, Xiaoyuan Chen
2013 PLoS ONE  
Citation: Nguyen VL, Kooi ME, Backes WH, van Hoof RHM, Saris AECM, et al. (2013) Suitability of Pharmacokinetic Models for Dynamic Contrast-Enhanced MRI of Abdominal Aortic Aneurysm Vessel Wall: A Comparison  ...  The aim of this study was to compare the suitability of three pharmacokinetic models to describe AAA vessel wall enhancement using dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI).  ...  vessel wall on dynamic contrast-enhanced MR images.  ... 
doi:10.1371/journal.pone.0075173 pmid:24098370 pmcid:PMC3788790 fatcat:kbvrmxgadneobjnwnwzl6alu4a

Statistical comparison of dynamic contrast-enhanced MRI pharmacokinetic models in human breast cancer

Xia Li, E. Brian Welch, A. Bapsi Chakravarthy, Lei Xu, Lori R. Arlinghaus, Jaime Farley, Ingrid A. Mayer, Mark C. Kelley, Ingrid M. Meszoely, Julie Means-Powell, Vandana G. Abramson, Ana M. Grau (+2 others)
2011 Magnetic Resonance in Medicine  
By fitting dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) data to an appropriate pharmacokinetic model, quantitative physiological parameters can be estimated.  ...  The pharmacokinetic models include: the fast exchange limit model with (FXL_v p ) and without (FXL) a plasma component, and the fast and slow exchange regime models (FXR and SXR, respectively).  ...  Acknowledgments We thank the National Institutes of Health for funding through NCI 1R01CA129961, NCI 1U01CA142565, and NCI 1P50 098131 and the Vanderbilt-Ingram Cancer Center Grant (NIH P30 CA68485).  ... 
doi:10.1002/mrm.23205 pmid:22127821 pmcid:PMC3291742 fatcat:htxkdwmt5bfpvji3jkx5o7zt7m

3-T Dynamic Contrast-Enhanced MRI of the Breast: Pharmacokinetic Parameters Versus Conventional Kinetic Curve Analysis

Riham H. El Khouli, Katarzyna J. Macura, Ihab R. Kamel, Michael A. Jacobs, David A. Bluemke
2011 American Journal of Roentgenology  
Purpose-To evaluate the incremental value of pharmacokinetic analysis of dynamic contrast enhanced (DCE) magnetic resonance imaging (MRI) compared to conventional breast MRI (morphology plus kinetic curve  ...  Patients underwent 3D high resolution T1 (3DT1) contrast enhanced MRI and dynamic contrast enhancement (DCE) MRI at 3T, and had pathology proven diagnosis (95%) or more than 2 years follow up confirming  ...  For dynamic contrast enhanced (DCE) MRI, both pharmacokinetic modeling and kinetic curve type analysis improve characterization of malignant and benign breast lesions.  ... 
doi:10.2214/ajr.10.4665 pmid:22109308 pmcid:PMC3496793 fatcat:qveky4asmveg7lc6alan5kqqjm

Registration of dynamic contrast-enhanced MRI using a progressive principal component registration (PPCR)

A Melbourne, D Atkinson, M J White, D Collins, M Leach, D Hawkes
2007 Physics in Medicine and Biology  
Registration of Dynamic Contrast-Enhanced Magnetic Resonance Images (DCE-MRI) is difficult.  ...  Using a model of pharmacokinetic uptake is a more desirable solution, but the difficulties of finding an applicable model, particularly over a wide field of view may be prohibitive [2] .  ...  Introduction: Registration of Dynamic Contrast-Enhanced Magnetic Resonance Images (DCE-MRI) is difficult.  ... 
doi:10.1088/0031-9155/52/17/003 pmid:17762077 fatcat:uzkasc2h4jdafbf5pct7ixw2ke

Dynamic contrast-enhanced MRI in cancer

Fiona J Gilbert, Trevor S Ahearn
2009 Imaging in Medicine  
As an area of active research, the imaging and modeling of dynamic contrast-enhanced MRI data has many challenges.  ...  Novel contrast agents and models contribute to a refining of the technique and its application as a diagnostic tool in cancer imaging. keywords: cancer n contrast agents n dynamic n MrI n pharmacokinetic  ...  As with macromolecular development, executive summary Dynamic contrast-enhanced MRI technique Dynamic contrast-enhanced (DCE) MRI is the sequential MRI of a tumor before, during and after intravenous  ... 
doi:10.2217/iim.09.17 fatcat:5hatoe66izevhdjp6wm5ioq4ym

Improved Leakage Correction for Single-Echo Dynamic Susceptibility Contrast Perfusion MRI Estimates of Relative Cerebral Blood Volume in High-Grade Gliomas by Accounting for Bidirectional Contrast Agent Exchange

K. Leu, J. L. Boxerman, T. F. Cloughesy, A. Lai, P. L. Nghiemphu, L. M. Liau, W. B. Pope, B. M. Ellingson
2016 American Journal of Neuroradiology  
Pharmacokinetic modeling of Gd-DTPA extravasation in brain tumors. Atheoretical framework to model DSC-MRI data acquired in the presence of contrast agent extravasation.  ...  Comparison of dynamic susceptibilityweighted contrast-enhanced MR methods: recommendations for measuring relative cerebral blood volume in brain tumors.  ... 
doi:10.3174/ajnr.a4759 pmid:27079371 pmcid:PMC4983482 fatcat:ksqipxhj4nfz3igvc5akrfepdq

Uterine cervical carcinoma: comparison of standard and pharmacokinetic analysis of time-intensity curves for assessment of tumor angiogenesis and patient survival

H Hawighorst, P G Knapstein, M V Knopp, W Weikel, G Brix, I Zuna, S O Schönberg, M Essig, P Vaupel, G van Kaick
1998 Cancer Research  
second (SI-U/s)] were calculated from a contrast-enhanced dynamic MRI series in 37 patients with biopsy-proven primary cervical cancer.  ...  to: (a) examine the association of standard and pharmacokinetic analysis of time-intensity curves in dynamic MRI with histomorphological markers of tumor angiogenesis [microvessel density (MVD) and vascular  ...  On the other hand, a variety of techniques including pharmacokinetic models have been proposed for the analysis of time-intensity curve measurements by dynamic MRI (9) (10) (11) (12) (13) .  ... 
pmid:9721867 fatcat:zd43aai4bjakhmmfzi6w5wqomm

Measurement of pharmacokinetic parameters in histologically graded invasive breast tumours using dynamic contrast-enhanced MRI

A RADJENOVIC, B J DALL, J P RIDGWAY, M A SMITH
2008 British Journal of Radiology  
: Dynamic contrast enhanced MRI (DCE-MRI) has demonstrated high sensitivity for detection of breast cancer.  ...  Measurement of pharmacokinetic parameters in histologically graded invasive breast tumours using dynamic contrast-enhanced MRI. British Journal of Radiology, 81 (962), 120-128.  ...  pharmacokinetic parameters in histologicallygraded invasive breast tumours using dynamic contrast enhanced MRI Abstract Dynamic contrast enhanced MRI (DCE-MRI) has demonstrated high sensitivity for detection  ... 
doi:10.1259/bjr/98435332 pmid:18070824 fatcat:5t566wm4jjdq5mis5z22bxeoue

Differentiation of prostatic carcinoma and benign prostatic hyperplasia: Correlation between dynamic Gd-DTPA-enhanced MR imaging and histopathology

Lindsay W. Turnbull, David L. Buckley, Lesley S. Turnbull, Gary P. Liney, Adrian J. Knowles
1999 Journal of Magnetic Resonance Imaging  
This study correlates the histopathological findings from 12 radical prostatectomy patients on a region-by-region basis, with pharmacokinetic modeling of dynamic contrast-enhanced (0.2 mmol dimeglumine  ...  As neovascularity is an independent indicator of pathological state, dynamic contrast-enhanced MRI may yield additional information.  ...  The purpose of this study was to examine the ability of dynamic contrast-enhanced MRI, analyzed quantitatively by pharmacokinetic modeling, to differentiate histologically proven benign from malignant  ... 
doi:10.1002/(sici)1522-2586(199902)9:2<311::aid-jmri24>3.0.co;2-w pmid:10077030 fatcat:2dxo3o4ydnegnmk25tkfmhpydi

Contrast-enhanced magnetic resonance imaging of the breast: the value of pharmacokinetic parameters derived from fast dynamic imaging during initial enhancement in classifying lesions

J. Veltman, M. Stoutjesdijk, R. Mann, H. J. Huisman, J. O. Barentsz, J. G. Blickman, C. Boetes
2008 European Radiology  
The value of pharmacokinetic parameters derived from fast dynamic imaging during initial enhancement in characterizing breast lesions on magnetic resonance imaging (MRI) was evaluated.  ...  The high spatial resolution images were recorded at a temporal resolution of 86 s (slow dynamic analysis).  ...  In the fast dynamic analysis, a workstation, developed in-house for the evaluation of dynamic contrast enhanced MRI, was used [29, 30] .  ... 
doi:10.1007/s00330-008-0870-8 pmid:18270714 pmcid:PMC2373858 fatcat:pac5jwlpwnecdktis65m7yk3vu

Comparison of choline and pharmacokinetic parameters in breast cancer measured by MR spectroscopic imaging and dynamic contrast enhanced MRI

Min-Ying Su, Hyun-Man Baik, Hon J Yu, Jeon-hor Chen, Rita S Mehta, Orhan Nalcioglu
2006 Technology in Cancer Research and Treatment  
by dynamic contrast enhanced MRI (DCE-MRI) and Choline (Cho) metabolism measured by proton MR spectroscopy imaging (MRSI).  ...  Corresponding DCE kinetics was measured from each voxel, and analyzed with a 2-compartmental model to obtain pharmacokinetic parameters Ktrans and k(ep).  ...  Fig.2 demonstrates a case with the mass type enhancement, presenting a pre-contrast hypointense, strongly enhanced lesion with well-defined boundary.  ... 
pmid:16866570 fatcat:gg2q3pk25fcztdhsk74wzd6pyq

Optimized Fast Dynamic Contrast-Enhanced Magnetic Resonance Imaging of the Prostate

Ahmed E. Othman, Florian Falkner, Petros Martirosian, Christina Schraml, Christian Schwentner, Dominik Nickel, Konstantin Nikolaou, Mike Notohamiprodjo
2016 Investigative Radiology  
Objective: The aim of this study was to evaluate the effect of sampling duration on pharmacokinetic parameters from dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) and their diagnostic  ...  Conclusions: Using fast optimized DCE-MRI of the prostate, a minimum sampling duration of 150 seconds is required for sufficient pharmacokinetic parameter estimates, providing a high diagnostic accuracy  ...  Dynamic contrast-enhanced MRI was acquired using a prototypical CDT-VIBE sequence.  ... 
doi:10.1097/rli.0000000000000213 pmid:26447494 fatcat:c3szsyablffq5m7ocowsbnnwli

Comparison of Voxel-Wise Tumor Perfusion Changes Measured With Dynamic Contrast-Enhanced (DCE) MRI and Volumetric DCE CT in Patients With Metastatic Brain Cancer Treated with Radiosurgery

2016 Tomography  
contrast-enhanced (DCE)-MRI metrics are evaluated against volumetric DCE-CT quantitative parameters as a standard for tracer-kinetic validation using a common 4-dimensional temporal dynamic analysis platform  ...  For DCE-MRI, the implementation of voxel-wise T 10 maps plays a key role in ensuring the accuracy of heterogeneous pharmacokinetic maps.  ...  and Engineering Research Council of Canada.  ... 
doi:10.18383/j.tom.2016.00178 pmid:30042966 pmcid:PMC6037934 fatcat:r5zmpqpcqbe6pc2kwo2v3ckvdu

Comparison between PUN and Tofts models in the quantification of dynamic contrast-enhanced MR imaging

S Mazzetti, A S Gliozzi, C Bracco, F Russo, D Regge, M Stasi
2012 Physics in Medicine and Biology  
Dynamic contrast-enhanced study in magnetic resonance imaging (DCE-MRI) is an important tool in oncology to visualize tissues vascularization and to define tumour aggressiveness on the basis of an altered  ...  Pharmacokinetic models are generally used to extract hemodynamic parameters, providing a quantitative description of the contrast uptake and wash-out.  ...  Conclusion The application of an empirical model to DCE-MRI data is a useful alternative to pharmacokinetic modelling.  ... 
doi:10.1088/0031-9155/57/24/8443 pmid:23202297 fatcat:5lrfth4t6vh53knnjxe4t5urom

Free breathing DCE-MRI with motion correction and its values for benign and malignant liver tumor differentiation

Xiaolin Zheng, Lihua Xiao, Xianmiao Fan, Ning Huang, Zihua Su, Xiao Xu
2015 Radiology of Infectious Diseases  
Conclusion: Dynamic contrast-enhanced MRI combined with tracer kinetic model and non-rigid registration was a feasible method for diagnosing of liver lesions under free breezing mode.  ...  Objective: 3D dynamic contrast enhanced (DCE) MRI with parallel imaging, a novel method to understand tumor vascularization in vivo, has been applied to liver in this work.  ...  Introduction Quantitative dynamic contrast-enhanced MRI (DCE-MRI) allows us to produce pharmacokinetic parameters, that can quantify endothelial permeability (K trans ) and fractional blood plasma volume  ... 
doi:10.1016/j.jrid.2015.07.001 fatcat:ml7zcmnvtfgl3pw3vw6wktkoem
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