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Retrospective analysis of 104 histologically proven adult brainstem gliomas: clinical symptoms, therapeutic approaches and prognostic factors

Thomas Reithmeier, Aanyo Kuzeawu, Bettina Hentschel, Markus Loeffler, Michael Trippel, Guido Nikkhah
2014 BMC Cancer  
The goal of this study was to analyze clinical, prognostic and therapeutic factors in a large series of histologically proven brainstem gliomas.  ...  Low KPS, age ≥ 40 and higher tumor grade have a negative impact on overall survival.  ...  University Dresden and the Department of Neurosurgery of the University of Bonn for enrolling patients into this study.  ... 
doi:10.1186/1471-2407-14-115 pmid:24555482 pmcid:PMC3975961 fatcat:cb2q6y2onff2rcrburjnyuz3ba

Molecular diagnostics of gliomas: state of the art

Markus J. Riemenschneider, Judith W. M. Jeuken, Pieter Wesseling, Guido Reifenberger
2010 Acta Neuropathologica  
grade, but may be complemented by a growing number of molecular tests for clinically relevant tissue-based biomarkers.  ...  for increasing our repertoire of clinically useful glioma markers.  ...  Moreover, low-grade (WHO grade II) diffuse gliomas have a strong tendency for malignant progression to anaplastic (WHO grade III) gliomas and eventually secondary glioblastomas (WHO grade IV).  ... 
doi:10.1007/s00401-010-0736-4 pmid:20714900 pmcid:PMC2955236 fatcat:tayuz2htbna4hbmj6ihiiuax7m

Infiltrative gliomas of the thalamus in children: the role of surgery in the era of H3 K27M mutant midline gliomas

Christian Dorfer, Thomas Czech, Johannes Gojo, Arthur Hosmann, Andreas Peyrl, Amedeo A. Azizi, Gregor Kasprian, Karin Dieckmann, Mariella G. Filbin, Christine Haberler, Karl Roessler, Irene Slavc
2020 Acta Neurochirurgica  
Neuroimaging data were reviewed for localization and extent of resection; pathology was re-reviewed according to the current WHO classification, including assessment of histone H3 K27 mutational status  ...  Resection ("any resection > 50%" vs "biopsy") and histological tumor grade ("°II" vs "°III+°IV") were statistically significant predictors of survival (univariate: p = 0.044 and p = 0.013, respectively  ...  Most neoplasms in this location are of glial lineage, with up to 50% showing low-grade histology [16] .  ... 
doi:10.1007/s00701-020-04589-y pmid:33090244 fatcat:jfrjampmnja6ngtgoeldxerwtm

Classification and management of anaplastic gliomas

Wolfgang Wick, Michael Weller
2009 Current Opinion in Neurology  
The current standard of care for first-line treatment in anaplastic gliomas is radio-or chemotherapy.  ...  Classification and management of anaplastic gliomas. Current Opinion in Neurology, 22(6):650-656. Abstract Purpose of review.  ...  The median OS data of this trial are in the range of 80 months, stressing the relevance to be care for long-term (neuro)toxicity similar to prior low-grade glioma trials (10) .  ... 
doi:10.1097/wco.0b013e3283329ce7 pmid:19770657 fatcat:ek5ubt57yjefdd2xgicrpaw644

Molecular Neuropathology of Gliomas

Markus Riemenschneider, Guido Reifenberger
2009 International Journal of Molecular Sciences  
They comprise a heterogeneous group of benign and malignant neoplasms that are histologically classified according to the World Health Organization (WHO) classification of tumors of the nervous system.  ...  The tremendous progress that has been made in the use of array-based profiling techniques will likely contribute to a further molecular refinement of glioma classification and lead to the identification  ...  Gliomas are histologically classified according to the World Health Organization (WHO) classification of tumors of the nervous system [2] , which combines tumor typing with the assignment of a defined  ... 
doi:10.3390/ijms10010184 pmid:19333441 pmcid:PMC2662467 fatcat:l5o6ak63vjc33amd5y3rqiwioy

The pathological diagnosis of diffuse gliomas: towards a smart synthesis of microscopic and molecular information in a multidisciplinary context

Pieter Wesseling, Johan M. Kros, Judith W.M. Jeuken
2011 Diagnostic Histopathology  
A multidisciplinary approach is mandatory for achieving an optimal diagnosis for patients with these tumours.  ...  Because of problems with tissue sampling and imprecise criteria for typing and grading, unequivocal histopathological classification of diffuse gliomas can be challenging.  ...  Grading of diffuse gliomas According to the WHO-2007 classification diffuse gliomas are graded as WHO grade II (low grade), WHO grade III (anaplastic) or WHO grade IV (glioblastoma) whereas WHO grade I  ... 
doi:10.1016/j.mpdhp.2011.08.005 fatcat:dq5jhhlkkjhv5f3v73j5y5hkne

Genetic analysis to complement histopathological diagnosis of brain tumors

M Nakamura, K Shimada, E Ishida, H Nakase, N Konishi
2007 Histology and Histopathology  
approaches to glioma classification.  ...  Oligodendrogliomas (WHO grade II) account for 2.7% of brain tumors and 5-18% of all gliomas.  ...  For cases showing various degrees of mixed morphology, histological separation of low-grade diffuse astrocytomas from oligodendrogliomas shows high inter-observer variability (Fig. 2) .  ... 
doi:10.14670/hh-22.327 pmid:17163407 fatcat:lyu7an7zgnbg7bmgcrlgijgm7m

Histologically Proven, Low-grade Brainstem Gliomas in Children

Kamran A. Ahmed, Nadia N. Laack, Laurence J. Eckel, Nicholas M. Orme, Nicholas M. Wetjen
2014 American Journal of Clinical Oncology  
To evaluate long-term overall survival (OS), progression-free survival (PFS), and outcomes in pathologically proven brainstem low-grade gliomas (BS-LGG) in children.  ...  A high proportion of patients (42%) had diffuse tumors and 13 patients (27%) had diffuse pontine gliomas (DPGs).  ...  As treatment and outcomes have been thought to be similar regardless of histology, this approach seems justifiable.  ... 
doi:10.1097/coc.0b013e31826b9903 pmid:23357966 pmcid:PMC4361935 fatcat:j3bvhvq64rgwflnbybibdsyqu4

Combinations of Single-Gene Biomarkers Can Precisely Stratify 1,028 Adult Gliomas for Prognostication

Aden Ka-Yin Chan, Zhi-Feng Shi, Kay Ka-Wai Li, Wei-Wei Wang, Hong Chen, Nellie Yuk-Fei Chung, Danny Tat-Ming Chan, Wai-Sang Poon, Herbert Ho-fung Loong, Xian-Zhi Liu, Zhen-Yu Zhang, Ying Mao (+1 others)
2022 Frontiers in Oncology  
The objective of this study was to establish a molecular grading scheme for adult gliomas using combinations of commonly available single-gene tests.  ...  , or H3 mutant) could significantly stratify this large cohort of gliomas for risk.  ...  However, it is not in regular use for the lower-grade glioma as a prognosticator, and most of the low histological grade IDH mutant gliomas are likely to be MGMT methylated.  ... 
doi:10.3389/fonc.2022.839302 pmid:35558510 pmcid:PMC9090434 fatcat:7i6mvkahuvbhlk2ceav6fmlr4i

Machine-learning-based Classification of Lower-grade gliomas and High-grade gliomas using Radiomic Features in Multi-parametric MRI [article]

Ge Cui, Jiwoong Jeong, Bob Press, Yang Lei, Hui-Kuo Shu, Tian Liu, Walter Curran, Hui Mao, Xiaofeng Yang
2019 arXiv   pre-print
The purpose of this study is to develop a machine-learning based classification method using radio-mic features of multi-parametric MRI to classify high-grade gliomas (HGG) and low-grade gliomas (LGG).  ...  Results: Optimized parameters showed that on average, the overall accuracy of our classification method was 0.913 or 73 out of 80 correct classifications, 36/40 for HGG and 37/40 for LGG, with an AUC of  ...  ACKNOWLEDGEMENTS This work was supported in parts by grants from National Institutes of Health [R01CA215718 to XY, R01CA203388 and R01CA169937 to HM] and Emory Winship Cancer Institute pilot grant.  ... 
arXiv:1911.10145v1 fatcat:f6b7kcctnzgepmf6fvopdj5yyy

Clinical multiplexed exome sequencing distinguishes adult oligodendroglial neoplasms from astrocytic and mixed lineage gliomas

Jane B. Cryan, Sam Haidar, Lori A. Ramkissoon, Wenya Linda Bi, David S. Knoff, Nikolaus Schultz, Malak Abedalthagafi, Loreal Brown, Patrick Y. Wen, David A. Reardon, Ian F. Dunn, Rebecca D. Folkerth (+8 others)
2014 OncoTarget  
In all, our results demonstrate that multiplexed exome sequencing can support evaluation and classification of adult low-grade gliomas with a single clinical test.  ...  Classifying adult gliomas remains largely a histologic diagnosis based on morphology; however astrocytic, oligodendroglial and mixed lineage tumors can display overlapping histologic features.  ...  progression from low to high grade gliomas.  ... 
doi:10.18632/oncotarget.2342 pmid:25257301 pmcid:PMC4226668 fatcat:6aqzvszelbd27j3ruvg6bbwq2e

Investigating machine learning techniques for MRI-based classification of brain neoplasms

Evangelia I. Zacharaki, Vasileios G. Kanas, Christos Davatzikos
2011 International Journal of Computer Assisted Radiology and Surgery  
algorithm and the KNN classifier and reached 96.9% when discriminating metastases from gliomas and 94.5% when discriminating high-grade from low-grade neoplasms.  ...  Conclusions-A computer-assisted classification framework is developed and used for differential diagnosis of brain neoplasms based on MRI.  ...  Acknowledgments This work was supported by a Marie Curie International Reintegration Grant within the 7th European Community Framework Programme and an NIH grant R01 NS042645.  ... 
doi:10.1007/s11548-011-0559-3 pmid:21516321 pmcid:PMC4373074 fatcat:72jqlxikmnemjm2knd34khicd4

Proceeding of Glioblastoma Multiforme (GBM): An Advanced Overview

Niraj Kumar Srivastava, Niraj Kumar Srivastava, Somnath Mukherjee
2020 Clinical Oncology and Cancer Biology  
Glioblastoma multiforme (GBM) is a central nervous system tumor of grade IV histological malignancy according to the WHO classification.  ...  There is always need of the development of new therapeutic approaches for GBM to improve the survival and quality of life.  ...  Acknowledgements Authors wish to thank Council of Scientific & Industrial Research  ... 
doi:10.31487/j.cocb.2020.02.02 fatcat:mno3biszh5bcjcitzmax2cukca

Pediatric supratentorial high-grade gliomas

Mandeep S. Tamber, James T. Rutka
2003 Neurosurgical Focus  
boy who had undergone 5000-rad radiotherapy at age 4 years for a low-grade optic chiasmatic glioma.  ...  to misclassify various low-grade glioma variants under the diagnostic umbrella of high-grade lesions.  ... 
doi:10.3171/foc.2003.14.2.2 pmid:15727422 fatcat:6qrpst6inzatjppwhgxz7qqzfq

EANO guidelines on the diagnosis and treatment of diffuse gliomas of adulthood

Michael Weller, Martin van den Bent, Matthias Preusser, Emilie Le Rhun, Jörg C. Tonn, Giuseppe Minniti, Martin Bendszus, Carmen Balana, Olivier Chinot, Linda Dirven, Pim French, Monika E. Hegi (+12 others)
2020 Nature Reviews Clinical Oncology  
This document is intended to be a source of reference for professionals involved in the management of adult patients with diffuse gliomas, for patients and caregivers, and for health-care providers.  ...  Through these evidence-based guidelines, a task force of EANO provides recommendations for the diagnosis, treatment and follow-up of adult patients with diffuse gliomas.  ...  Accordingly, glioma classification integrates histological tumour typing and grading as well as analyses of molecular markers (fig. 1 ).  ... 
doi:10.1038/s41571-020-00447-z pmid:33293629 pmcid:PMC7904519 fatcat:d4litelrqjhdnmydiooiza7u7m
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