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A Combinatorial Model for Dentate Gyrus Sparse Coding
2017
Neural Computation
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The dentate gyrus forms a critical link between the entorhinal cortex and CA3 by providing a sparse version of the signal. ...
Although an active region of study and theory, few logically rigorous arguments detail the dentate gyrus's (DG) coding. We suggest a theoretically tractable, combinatorial model for this action. ...
Sandia National Laboratories is a multi-mission laboratory managed and operated by Sandia ...
doi:10.1162/neco_a_00905
pmid:27764589
fatcat:c4me64kq3zan5nlgknwb3jfoby
Multicolor RGB Marking Allows Morphometric and Functional Analysis of Hippocampal Granule Neurons at the Single-Cell Level
2015
Human Gene Therapy
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gyrus. ...
Identifying and tracking cells in the brain is a challenging task, requiring advanced molecular biology techniques and precise anatomical information. ...
Acknowledgments The authors are indebted to many colleagues for kind support with various cells and constructs: R. ...
doi:10.1089/hum.2015.010
pmid:25894663
pmcid:PMC4492707
fatcat:g65fzdkc3vatvnroyscd3q3nbe
BATTLE: Genetically engineered strategies for split-tunable allocation of multiple transgenes in the nervous system
2020
iScience
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We demonstrated the versatility of these strategies and technologies in inducing strong and multi-sparse allocations of multiple transgenes. ...
Here, we created a concept called the "battle of transgenes," based on which we generated strategies using genetically engineered battles of multiple recombinases. ...
(E) Representative maximum intensity projection image of dentate gyrus infected with BATTLE-2 (double sparse). ...
doi:10.1016/j.isci.2020.101248
pmid:32629613
pmcid:PMC7322263
fatcat:fdssfqqkirb7tj7dw5irkuirfq
Stress, epigenetic control of gene expression and memory formation
2012
Experimental Neurology
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Making memories of a stressful life event is essential for an organism's survival as it allows it to adapt and respond in a more appropriate manner should the situation occur again. ...
The neurotransmitter glutamate and the ERK MAPK signaling pathway play a principal role in learning and memory. ...
We found that indeed in addition to GRs concurrent activation of NMDA-Rs were required for the formation of the combinatorial histone H3 phospho-acetylation mark and c-Fos induction in the dentate gyrus ...
doi:10.1016/j.expneurol.2011.03.022
pmid:21466804
fatcat:a37vmsntnrexrj5sanazchv7ri
Neuronal activity modifies the chromatin accessibility landscape in the adult brain
2017
Nature Neuroscience
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Some changes remain stable for at least twenty-four hours. ...
Here we compared chromatin accessibility landscapes of adult mouse dentate granule neurons in vivo before and after synchronous neuronal activation using ATAC-seq. ...
Acknowledgments We thank members of Song and Ming laboratories for discussion, Kimberly Christian for comments, Y. Cai and L. Liu for technical support. ...
doi:10.1038/nn.4494
pmid:28166220
pmcid:PMC5325677
fatcat:ylwm2yvl5jexbkgh63om64e7fi
Intelligent encoding and economical communication in the visual stream
[article]
2004
arXiv
pre-print
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The theory of computational complexity is used to underpin a recent model of neocortical sensory processing. ...
We argue that encoding into reconstruction networks is appealing for communicating agents using Hebbian learning and working on hard combinatorial problems, which are easy to verify. ...
The method is called sparse code shrinkage (SCS) (Hyvärinen, 1999) . ...
arXiv:q-bio/0403022v1
fatcat:vwg2jwerfvdkvnmwqkbacyytr4
Quantitative properties of a feedback circuit predict frequency-dependent pattern separation
[article]
2019
bioRxiv
pre-print
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We have quantitatively determined key properties of net feedback inhibition in the mouse dentate gyrus, a region critically involved in pattern separation. ...
Feedback inhibitory motifs are important for pattern separation in several species. ...
A Combinatorial Model for Dentate
1
1
6
8
Gyrus Sparse Coding. ...
doi:10.1101/813188
fatcat:l6hvcp2kj5dqrbf7mo25ii5ehy
Exercise-induced enhancement of synaptic function triggered by the inverse BAR protein, Mtss1L
[article]
2019
bioRxiv
pre-print
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Only a few dentate granule cells were activated at baseline, but two hours of voluntary exercise markedly increased the number of activated neurons. ...
To address this issue, we exposed mice to a single episode of voluntary exercise, and permanently marked mature dentate granule cells activated specifically during exercise using conditional Fos-TRAP mice ...
Aimone, A Combinatorial Model for 5 Dentate Gyrus Sparse Coding. Neural Comput 29, 94-117 (2017). 8. L. Bolz, S. Heigele, J. ...
doi:10.1101/545582
fatcat:vo43jfqrtzgobndi6xgkwwkfmy
MicroRNA Regulation of the Synaptic Plasticity-Related Gene Arc
2012
PLoS ONE
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In the adult brain, LTP induction in the dentate gyrus triggered massive upregulation of Arc and upregulation of miR-132 without affecting levels of mature Arc-targeting miRNAs. ...
Turning to examine miRNA localization, qPCR analysis of dentate gyrus synaptoneurosome and total lysates fractions demonstrated synaptic enrichment relative to small nucleolar RNA. ...
We asked whether Arc-targeting miRNAs are regulated in vivo by synaptic stimulation, using LTP in the dentate gyrus of anesthetized rats as a model system. ...
doi:10.1371/journal.pone.0041688
pmid:22844515
pmcid:PMC3406043
fatcat:rjuh4bu65zbyxlgrh5ot4f27sa
Epigenetic mechanisms in stress and adaptation
2011
Brain, behavior, and immunity
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This pathway can be induced by a range of challenging experiences including forced swimming, Morris water maze learning, fear conditioning and exposure to the radial maze. ...
This pathway can be induced by a range of challenging experiences including forced swimming, Morris water maze learning, fear conditioning and exposure to the radial maze. ...
which are essential for maintaining the methylation code (Wu and Zhang, 2010) . ...
doi:10.1016/j.bbi.2011.06.005
pmid:21704151
fatcat:7pgsjy6acva2bas4ssewpepi2i
Computational Modeling of Adult Neurogenesis
2016
Cold Spring Harbor Perspectives in Biology
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gyrus area of the hippocampus. ...
Notably, the two mammalian regions where neurogenesis is typically studied, the olfactory bulb (OB) and the dentate gyrus (DG) region of the hippocampus, have considerably different functions. ...
Figure 1 . 1 Overview of different scales relevant to characterizing neurogenesis function in the dentate gyrus (DG). ...
doi:10.1101/cshperspect.a018960
pmid:26933191
pmcid:PMC4817800
fatcat:bhhcee5os5cubovakyespfgsi4
Parallel computational subunits in dentate granule cells generate multiple place fields
2009
BMC Neuroscience
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Using a simple cascade model, we demonstrate that triggering somatic firing by a relatively small dendritic branch requires the amplification of local events by dendritic spiking and synaptic plasticity ...
of individual dendritic spikes in the soma requires a low branch number. ...
Acknowledgments Authors are grateful for the useful discussions held with the members of the Budapest Computational Neuroscience Group. ...
doi:10.1186/1471-2202-10-s1-p39
fatcat:ota5h2bm2jcx3bumsi5vrxahie
Parallel Computational Subunits in Dentate Granule Cells Generate Multiple Place Fields
2009
PLoS Computational Biology
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Using a simple cascade model, we demonstrate that triggering somatic firing by a relatively small dendritic branch requires the amplification of local events by dendritic spiking and synaptic plasticity ...
of individual dendritic spikes in the soma requires a low branch number. ...
Acknowledgments Authors are grateful for the useful discussions held with the members of the Budapest Computational Neuroscience Group. ...
doi:10.1371/journal.pcbi.1000500
pmid:19750211
pmcid:PMC2730574
fatcat:2edrm6izsbanthba7anzlve3xa
Mutual Inhibition with Few Inhibitory Cells via Nonlinear Inhibitory Synaptic Interaction
2019
Neural Computation
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In this letter, we propose a model of nonlinear interaction of inhibitory synapses on dendritic compartments of excitatory neurons that allows the excitatory neurons to mediate inhibitory signals through ...
a subset of the inhibitory population. ...
Example: Decorrelation in Dentate Gyrus. ...
doi:10.1162/neco_a_01230
pmid:31525311
fatcat:ws4a7lieo5c7jecj53yte4zyoy
GnRH Receptor Gene Expression in the Developing Rat Hippocampus: Transcriptional Regulation and Potential Roles in Neuronal Plasticity
2011
Endocrinology
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Analysis of transcription factors together with transient transfection assays in hippocampal neurons indicated that the combinatorial code governing the hippocampusspecific expression of the Gnrhr is distinct ...
Using a previously described transgenic mouse model bearing the human placental alkaline phosphatase reporter gene under the control of the rat Gnrhr promoter, we established a positive correlation between ...
Acknowledgments Address all correspondence and requests for reprints to: Dr. ...
doi:10.1210/en.2010-0840
pmid:21123436
fatcat:htlf3vmjyvg5ffgf5nhwacahjy
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