Filters








252 Hits in 5.1 sec

A Combinatorial Model for Dentate Gyrus Sparse Coding

William Severa, Ojas Parekh, Conrad D. James, James B. Aimone
2017 Neural Computation  
The dentate gyrus forms a critical link between the entorhinal cortex and CA3 by providing a sparse version of the signal.  ...  Although an active region of study and theory, few logically rigorous arguments detail the dentate gyrus's (DG) coding. We suggest a theoretically tractable, combinatorial model for this action.  ...  Sandia National Laboratories is a multi-mission laboratory managed and operated by Sandia  ... 
doi:10.1162/neco_a_00905 pmid:27764589 fatcat:c4me64kq3zan5nlgknwb3jfoby

Multicolor RGB Marking Allows Morphometric and Functional Analysis of Hippocampal Granule Neurons at the Single-Cell Level

Diego Gomez-Nicola, Kristoffer Riecken, V. Hugh Perry, Boris Fehse
2015 Human Gene Therapy  
gyrus.  ...  Identifying and tracking cells in the brain is a challenging task, requiring advanced molecular biology techniques and precise anatomical information.  ...  Acknowledgments The authors are indebted to many colleagues for kind support with various cells and constructs: R.  ... 
doi:10.1089/hum.2015.010 pmid:25894663 pmcid:PMC4492707 fatcat:g65fzdkc3vatvnroyscd3q3nbe

BATTLE: Genetically engineered strategies for split-tunable allocation of multiple transgenes in the nervous system

Keigo Kohara, Akitoshi Inoue, Yousuke Nakano, Hirokazu Hirai, Takuya Kobayashi, Masato Maruyama, Ryosuke Baba, Chiho Kawashima
2020 iScience  
We demonstrated the versatility of these strategies and technologies in inducing strong and multi-sparse allocations of multiple transgenes.  ...  Here, we created a concept called the "battle of transgenes," based on which we generated strategies using genetically engineered battles of multiple recombinases.  ...  (E) Representative maximum intensity projection image of dentate gyrus infected with BATTLE-2 (double sparse).  ... 
doi:10.1016/j.isci.2020.101248 pmid:32629613 pmcid:PMC7322263 fatcat:fdssfqqkirb7tj7dw5irkuirfq

Stress, epigenetic control of gene expression and memory formation

Alexandra F. Trollope, María Gutièrrez-Mecinas, Karen R. Mifsud, Andrew Collins, Emily A. Saunderson, Johannes M.H.M. Reul
2012 Experimental Neurology  
Making memories of a stressful life event is essential for an organism's survival as it allows it to adapt and respond in a more appropriate manner should the situation occur again.  ...  The neurotransmitter glutamate and the ERK MAPK signaling pathway play a principal role in learning and memory.  ...  We found that indeed in addition to GRs concurrent activation of NMDA-Rs were required for the formation of the combinatorial histone H3 phospho-acetylation mark and c-Fos induction in the dentate gyrus  ... 
doi:10.1016/j.expneurol.2011.03.022 pmid:21466804 fatcat:a37vmsntnrexrj5sanazchv7ri

Neuronal activity modifies the chromatin accessibility landscape in the adult brain

Yijing Su, Jaehoon Shin, Chun Zhong, Sabrina Wang, Prith Roychowdhury, Jongseuk Lim, David Kim, Guo-li Ming, Hongjun Song
2017 Nature Neuroscience  
Some changes remain stable for at least twenty-four hours.  ...  Here we compared chromatin accessibility landscapes of adult mouse dentate granule neurons in vivo before and after synchronous neuronal activation using ATAC-seq.  ...  Acknowledgments We thank members of Song and Ming laboratories for discussion, Kimberly Christian for comments, Y. Cai and L. Liu for technical support.  ... 
doi:10.1038/nn.4494 pmid:28166220 pmcid:PMC5325677 fatcat:ylwm2yvl5jexbkgh63om64e7fi

Intelligent encoding and economical communication in the visual stream [article]

Andras Lorincz
2004 arXiv   pre-print
The theory of computational complexity is used to underpin a recent model of neocortical sensory processing.  ...  We argue that encoding into reconstruction networks is appealing for communicating agents using Hebbian learning and working on hard combinatorial problems, which are easy to verify.  ...  The method is called sparse code shrinkage (SCS) (Hyvärinen, 1999) .  ... 
arXiv:q-bio/0403022v1 fatcat:vwg2jwerfvdkvnmwqkbacyytr4

Quantitative properties of a feedback circuit predict frequency-dependent pattern separation [article]

Oliver Braganza, Daniel Mueller-Komorowska, Tony Kelly, Heinz Beck
2019 bioRxiv   pre-print
We have quantitatively determined key properties of net feedback inhibition in the mouse dentate gyrus, a region critically involved in pattern separation.  ...  Feedback inhibitory motifs are important for pattern separation in several species.  ...  A Combinatorial Model for Dentate 1 1 6 8 Gyrus Sparse Coding.  ... 
doi:10.1101/813188 fatcat:l6hvcp2kj5dqrbf7mo25ii5ehy

Exercise-induced enhancement of synaptic function triggered by the inverse BAR protein, Mtss1L [article]

Christina Chatzi, Yingyu Zhang, William D. Hendricks, Yang Chen, Eric Schnell, Richard H. Goodman, Gary L. Westbrook
2019 bioRxiv   pre-print
Only a few dentate granule cells were activated at baseline, but two hours of voluntary exercise markedly increased the number of activated neurons.  ...  To address this issue, we exposed mice to a single episode of voluntary exercise, and permanently marked mature dentate granule cells activated specifically during exercise using conditional Fos-TRAP mice  ...  Aimone, A Combinatorial Model for 5 Dentate Gyrus Sparse Coding. Neural Comput 29, 94-117 (2017). 8. L. Bolz, S. Heigele, J.  ... 
doi:10.1101/545582 fatcat:vo43jfqrtzgobndi6xgkwwkfmy

MicroRNA Regulation of the Synaptic Plasticity-Related Gene Arc

Karin Wibrand, Balagopal Pai, Taweeporn Siripornmongcolchai, Margarethe Bittins, Birgitte Berentsen, May Lillian Ofte, Arwed Weigel, Kai Ove Skaftnesmo, Clive R. Bramham, Alfons Navarro
2012 PLoS ONE  
In the adult brain, LTP induction in the dentate gyrus triggered massive upregulation of Arc and upregulation of miR-132 without affecting levels of mature Arc-targeting miRNAs.  ...  Turning to examine miRNA localization, qPCR analysis of dentate gyrus synaptoneurosome and total lysates fractions demonstrated synaptic enrichment relative to small nucleolar RNA.  ...  We asked whether Arc-targeting miRNAs are regulated in vivo by synaptic stimulation, using LTP in the dentate gyrus of anesthetized rats as a model system.  ... 
doi:10.1371/journal.pone.0041688 pmid:22844515 pmcid:PMC3406043 fatcat:rjuh4bu65zbyxlgrh5ot4f27sa

Epigenetic mechanisms in stress and adaptation

Karen R. Mifsud, María Gutièrrez-Mecinas, Alexandra F. Trollope, Andrew Collins, Emily A. Saunderson, Johannes M.H.M. Reul
2011 Brain, behavior, and immunity  
This pathway can be induced by a range of challenging experiences including forced swimming, Morris water maze learning, fear conditioning and exposure to the radial maze.  ...  This pathway can be induced by a range of challenging experiences including forced swimming, Morris water maze learning, fear conditioning and exposure to the radial maze.  ...  which are essential for maintaining the methylation code (Wu and Zhang, 2010) .  ... 
doi:10.1016/j.bbi.2011.06.005 pmid:21704151 fatcat:7pgsjy6acva2bas4ssewpepi2i

Computational Modeling of Adult Neurogenesis

James B. Aimone
2016 Cold Spring Harbor Perspectives in Biology  
gyrus area of the hippocampus.  ...  Notably, the two mammalian regions where neurogenesis is typically studied, the olfactory bulb (OB) and the dentate gyrus (DG) region of the hippocampus, have considerably different functions.  ...  Figure 1 . 1 Overview of different scales relevant to characterizing neurogenesis function in the dentate gyrus (DG).  ... 
doi:10.1101/cshperspect.a018960 pmid:26933191 pmcid:PMC4817800 fatcat:bhhcee5os5cubovakyespfgsi4

Parallel computational subunits in dentate granule cells generate multiple place fields

Balázs Ujfalussy, Tamás Kiss, Péter Érdi
2009 BMC Neuroscience  
Using a simple cascade model, we demonstrate that triggering somatic firing by a relatively small dendritic branch requires the amplification of local events by dendritic spiking and synaptic plasticity  ...  of individual dendritic spikes in the soma requires a low branch number.  ...  Acknowledgments Authors are grateful for the useful discussions held with the members of the Budapest Computational Neuroscience Group.  ... 
doi:10.1186/1471-2202-10-s1-p39 fatcat:ota5h2bm2jcx3bumsi5vrxahie

Parallel Computational Subunits in Dentate Granule Cells Generate Multiple Place Fields

Balázs Ujfalussy, Tamás Kiss, Péter Érdi, Boris S. Gutkin
2009 PLoS Computational Biology  
Using a simple cascade model, we demonstrate that triggering somatic firing by a relatively small dendritic branch requires the amplification of local events by dendritic spiking and synaptic plasticity  ...  of individual dendritic spikes in the soma requires a low branch number.  ...  Acknowledgments Authors are grateful for the useful discussions held with the members of the Budapest Computational Neuroscience Group.  ... 
doi:10.1371/journal.pcbi.1000500 pmid:19750211 pmcid:PMC2730574 fatcat:2edrm6izsbanthba7anzlve3xa

Mutual Inhibition with Few Inhibitory Cells via Nonlinear Inhibitory Synaptic Interaction

Felix Weissenberger, Marcelo Matheus Gauy, Xun Zou, Angelika Steger
2019 Neural Computation  
In this letter, we propose a model of nonlinear interaction of inhibitory synapses on dendritic compartments of excitatory neurons that allows the excitatory neurons to mediate inhibitory signals through  ...  a subset of the inhibitory population.  ...  Example: Decorrelation in Dentate Gyrus.  ... 
doi:10.1162/neco_a_01230 pmid:31525311 fatcat:ws4a7lieo5c7jecj53yte4zyoy

GnRH Receptor Gene Expression in the Developing Rat Hippocampus: Transcriptional Regulation and Potential Roles in Neuronal Plasticity

Anne-Laure Schang, Valérie Ngô-Muller, Christian Bleux, Anne Granger, Marie-Claude Chenut, Catherine Loudes, Solange Magre, Raymond Counis, Joëlle Cohen-Tannoudji, Jean-Noël Laverrière
2011 Endocrinology  
Analysis of transcription factors together with transient transfection assays in hippocampal neurons indicated that the combinatorial code governing the hippocampusspecific expression of the Gnrhr is distinct  ...  Using a previously described transgenic mouse model bearing the human placental alkaline phosphatase reporter gene under the control of the rat Gnrhr promoter, we established a positive correlation between  ...  Acknowledgments Address all correspondence and requests for reprints to: Dr.  ... 
doi:10.1210/en.2010-0840 pmid:21123436 fatcat:htlf3vmjyvg5ffgf5nhwacahjy
« Previous Showing results 1 — 15 out of 252 results