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Chromatin topology and the timing of enhancer function at the HoxD locus

Eddie Rodríguez-Carballo, Lucille Lopez-Delisle, Andréa Willemin, Leonardo Beccari, Sandra Gitto, Bénédicte Mascrez, Denis Duboule
2020 Proceedings of the National Academy of Sciences of the United States of America  
These two regulations are exclusive from one another and emanate from two distinct topologically associating domains (TADs) flanking HoxD, both containing a range of appropriate enhancer sequences.  ...  The HoxD gene cluster is critical for proper limb formation in tetrapods.  ...  We also thank Ibai Irastorza-Azcarate and Asier Ullate-Agote for their help in implementing the 4Cin pipeline.  ... 
doi:10.1073/pnas.2015083117 pmid:33229569 fatcat:nryil6rlqfbcdohhy7j4lyevvq

Chromatin Topology And The Timing Of Enhancer Function At The HoxD Locus [article]

Edgardo Rodriguez-Carballo, Lucille Lopez-Delisle, Andrea Willemin, Leonardo Beccari, Sandra Gitto, Benedicte Mascrez, Denis Duboule
2020 bioRxiv   pre-print
These two regulations are exclusive from one another and emanate from two distinct TADs flanking HoxD, both containing a range of appropriate enhancer sequences.  ...  The HoxD gene cluster is critical for proper limb formation in tetrapods.  ...  A, B. Virtual Hi-C maps of wild-type (A) and del(CS38-40) (B) as reconstituted from 4C-seq datasets of E9 forelimb buds.  ... 
doi:10.1101/2020.07.12.199109 fatcat:ob2diwhqlnfprfxzg5lf2gn65i