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Predicting Motor Outcome of Subthalamic Nucleus Deep Brain Stimulation for Parkinson's Disease Using Quantitative Susceptibility Mapping and Radiomics: A Pilot Study

Yu Liu, Bin Xiao, Chencheng Zhang, Junchen Li, Yijie Lai, Feng Shi, Dinggang Shen, Linbin Wang, Bomin Sun, Yan Li, Zhijia Jin, Hongjiang Wei (+6 others)
2021 Frontiers in Neuroscience  
BackgroundEmerging evidence indicates that iron distribution is heterogeneous within the substantia nigra (SN) and it may reflect patient-specific trait of Parkinson's Disease (PD).  ...  The bilateral SN were segmented based on preoperative quantitative susceptibility mapping to extract susceptibility features using RA-ML.  ...  The texture analyses of the SN showed the superiority of QSM to R2 * map in discriminating PD and HC in one study .  ... 
doi:10.3389/fnins.2021.731109 pmid:34557069 pmcid:PMC8452872 fatcat:xadsbuqllbdv5njlhasvjvpohy

MRI-Based Radiomics of Basal Nuclei in Differentiating Idiopathic Parkinson's Disease From Parkinsonian Variants of Multiple System Atrophy: A Susceptibility-Weighted Imaging Study

Huize Pang, Ziyang Yu, Renyuan Li, Huaguang Yang, Guoguang Fan
2020 Frontiers in Aging Neuroscience  
To investigate the value of MRI-based radiomic model based on the radiomic features of different basal nuclei in differentiating idiopathic Parkinson's disease (IPD) from Parkinsonian variants of multiple  ...  Radiomics was applied to the 3T susceptibility- weighted imaging (SWI) from 102 MSA-P patients and 83 IPD patients (allocated to a training and a testing cohort, 7:3 ratio).  ...  ACKNOWLEDGMENTS We thank LetPub ( for its linguistic assistance during the preparation of this manuscript.  ... 
doi:10.3389/fnagi.2020.587250 pmid:33281598 pmcid:PMC7689200 fatcat:c42htvf2l5cl3g6mgkh6be6zta

Multi-centre, multi-vendor reproducibility of 7T QSM and R2* in the human brain: results from the UK7T study [article]

Catarina Rua, William T Clarke, Ian D Driver, Olivier Mougin, Andrew T Morgan, Stuart Clare, Susan Francis, Keith Muir, David Porter, Richard Wise, Adrian Carpenter, Guy B Wiliams (+3 others)
2020 biorxiv/medrxiv   pre-print
T2*-weighted MRI images can be processed to produce quantitative susceptibility maps (QSM) and R2* maps.  ...  The median ICC from within- and cross-site R2* data was 0.98 and 0.91, respectively.  ...  Acknowledgements The UK7T Network and this work was funded by the UK's Medical Research Council (MRC) [MR/N008537/1]. We thank Dr.  ... 
doi:10.1101/2020.04.22.055624 fatcat:3qc7mckvpvf4zl7yz7rj7dir5m

Multi-centre, multi-vendor reproducibility of 7T QSM and R2* in the human brain: results from the UK7T study

Catarina Rua, William T Clarke, Ian D Driver, Olivier Mougin, Andrew T. Morgan, Stuart Clare, Susan Francis, Keith Muir, Richard Wise, Adrian Carpenter, Guy Williams, James B Rowe (+2 others)
2020 NeuroImage  
T2*-weighted MRI images can be processed to produce quantitative susceptibility maps (QSM) and R2* maps.  ...  Mean susceptibility (χ) and R2* values agreed broadly with literature values in all ROIs. The inter-site within-subject standard deviation was 0.001 - 0.005 ppm (χ) and 0.0005 - 0.001 ms-1 (R2*).  ...  Acknowledgements The UK7T Network and this work was funded by the UK's Medical Research Council (MRC) [MR/N008537/1]. We thank Dr.  ... 
doi:10.1016/j.neuroimage.2020.117358 pmid:32916289 pmcid:PMC7480266 fatcat:noekpovbubca5d4jbeylu6wb3q

Methodological Considerations for Neuroimaging in Deep Brain Stimulation of the Subthalamic Nucleus in Parkinson's Disease Patients

Bethany R. Isaacs, Max C. Keuken, Anneke Alkemade, Yasin Temel, Pierre-Louis Bazin, Birte U. Forstmann
2020 Journal of Clinical Medicine  
Deep brain stimulation (DBS) of the subthalamic nucleus is a neurosurgical intervention for Parkinson's disease patients who no longer appropriately respond to drug treatments.  ...  One solution for increasing the success and efficacy of DBS is to optimize preoperative planning procedures via sophisticated neuroimaging techniques such as high-resolution MRI and higher field strengths  ...  The top row shows MP2RAGE T1-weighted, T1, T2*, and R2* maps and a quantitative susceptibility map (QSM) image obtained at 7 T within a single multi echo (ME) MP2RAGE sequence.  ... 
doi:10.3390/jcm9103124 pmid:32992558 pmcid:PMC7600568 fatcat:zaparmvmr5avbkibibn57citbm

Segmentation of substantia nigra and red nucleus in MRI images : application to Parkinson's disease [article]

Dibash Basukala, University Of Canterbury
Accurate segmentation of substantia nigra (SN) and red nucleus (RN) is challenging, yet important for understanding health problems like Parkinson's disease (PD).  ...  This thesis proposes robust algorithms to segment SN and RN from T2*-weighted images and quantitative susceptibility mapping (QSM) MRI.  ...  ., 2018) performed study on quantifying iron deposition within the substantia nigra of Parkinson's disease by quantitative susceptibility mapping.  ... 
doi:10.26021/10821 fatcat:txglirh5lvdkzgjylo2wh6mqza

2014 Biennial Meeting of the American Society for Stereotactic and Functional Neurosurgery. Washington, D.C., USA, May 31-June 3, 2014: Abstracts

2014 Stereotactic and Functional Neurosurgery  
patients with Parkinson's disease (PD).  ...  Segmentations and 3D volume rendering of the anatomical target (GPi or STN) and adjacent structures were generated based on susceptibility-weighted images (SWI) and T2-weighted images acquired at 7T.  ... 
doi:10.1159/000363530 pmid:24902536 fatcat:f3ptvsfgnfat7osvq5gugpk4gq

Modeling & Analysis

2003 NeuroImage  
Usually, these maps rely on a 3D coordinate system related to the Talairach atlas.  ...  In each case, one or two voxels in areas of high susceptibility were responsible for the false-positive result.  ...  We acquired a second MRI scan (discordant twins 10.8±3.3 months later, control twins 26.4±9.9 months) and compared intra-pair differences between the two timepoints and two groups to obtain a map of disease-specific  ... 
doi:10.1016/s1053-8119(05)70006-9 fatcat:zff2suxcofbxvetfrwfwcxi3zm

1st Annual Meeting: The Canadian Association for Neuroscience / Association canadienne de neuroscience

2007 Canadian Journal of Neurological Sciences  
inclusions (Lewy bodies) and loss of neurons in the substantia nigra.  ...  It is mapped to 12q12, which is within a locus reported for Parkinson's disease. The 5'-flanking region contains an enhancer core motif and binding sites for AP-1, 2 and LF-A1.  ... 
doi:10.1017/s0317167100017066 fatcat:aupmr4ntyjd6xes4gp5epa2epm

Brain PET Poster Sessions PP01-M01 to PP02-N07

2019 Journal of Cerebral Blood Flow and Metabolism  
Highthroughput rat brain PET imaging and automatic spatial normalization of the dopamine D2/3 receptor ligand [F-18]fallypride.  ...  Acknowledgements The authors would like to thank A. Leukona, X. Rı´os, V. Salinas for technical support in radiosynthesis and technical assistance in the PET studies.  ...  Acknowledgements Funding from ANR CYCLOPS (ANR-15-CE17-0020) and RHU MARVELOUS (ANR-16-RHUS-0009)  ... 
doi:10.1177/0271678x19851018 pmid:31265793 pmcid:PMC6610575 fatcat:auejdo6e3rb2pjtxgqq6rkm7ie

American Association of Neuropathologists, Inc. Abstracts of the 97th Annual Meeting June 10-13, 2021 St. Louis, Missouri

2021 Journal of Neuropathology and Experimental Neurology  
Interestingly, iPSC-derived FTD neurons also had a significant effect on the survival of host neurons and on glial cell responses when transplanted into the brains of immunocompromised mice indicating  ...  These findings demonstrate that a combinatorial approach applying snRNA-seq on patient brain tissue and a dynamic iPSC cell model comprises a powerful tool to identify disease phenotypes in neural cells  ...  On post-mortem examination, there was no evidence of atrophy and the substantia nigra was well-pigmented.  ... 
doi:10.1093/jnen/nlab042 pmid:34087938 fatcat:rgowg3kxi5ghpbylpalr2rxkj4

Abstracts of the 16th Annual Meeting of The Israel Society for Neuroscience: Eilat, Israel, November 25–27, 2007

2007 Neural Plasticity  
poster presentations, and the program of the meeting is mainly based on the 338 received abstracts which are published in this volume.  ...  The primary goal of the society was to promote and disseminate the knowledge and understanding acquired by its members, and to strengthen interactions between them.  ...  The effects of music background on sleep efficiency, anxiety and depression in Schizophrenia patients  ... 
doi:10.1155/2007/30585 pmid:25148070 pmcid:PMC2366074 fatcat:u4tjfw6shnaxpnzwezieeiqnpm

41st Meeting of the Canadian Congress of Neurological Sciences

2006 Canadian Journal of Neurological Sciences  
Severity of bleeding: mild = requiring no special treatment; moderate = requiring specific treatment but no blood  ...  Results: Rotenone reduced the number of TH immunoreactive neurons in the substantia nigra pars compacta (SNc) (p< 0.05).  ...  Brain MRI with infarction due to vasculitis in substantia nigra right. Antinuclear antibodies 1:320.  ... 
doi:10.1017/s0317167100017042 fatcat:ew6akmg5mzdxxpcmbteo7rlw4e

Abstracts from the International Society for Therapeutic Ultrasound Conference 2017

2018 Journal of Therapeutic Ultrasound  
However, one potential issue of weekly pFUS+MB treatments is the lack of data on the longterm effects on inflammation.  ...  a noninvasive adjuvant treatment for malignancies and neurodegenerative diseases.  ...  Acknowledgements This work was supported by the Bettencourt Schueller Foundation and the "Agence Nationale de la Recherche" under the program "Future Investments" with the reference ANR-10-EQPX-15.  ... 
doi:10.1186/s40349-018-0110-x fatcat:4nn4nwntgbfl5cdwvqc3wfxszu

American Association of Neuropathologists, Inc.: Abstracts of the 86thAnnual Meeting June 10-13, 2010 Philadelphia, PA

2010 Journal of Neuropathology and Experimental Neurology  
Taupositive neurofibrillary tangles were noted within multiple brainstem nuclei including the substantia nigra, locus coeruleus, and reticular formation.  ...  Lesser degrees of iron deposition were found in the caudate and putamen, sparing the substantia nigra, red nucleus, and dentate nucleus.  ...  This case is unusual in terms of the location of the tumor, young age of the patient, and lack of a predisposing immune compromised state.  ... 
doi:10.1097/nen.0b013e3181deb5a1 fatcat:xyiuly7njjfdvgm42s6y4uue4m
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