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3D mapping of neuronal migration in the embryonic mouse brain with magnetic resonance microimaging

Abby E. Deans, Youssef Zaim Wadghiri, Orlando Aristizábal, Daniel H. Turnbull
2015 NeuroImage  
Unlike histology, magnetic resonance microimaging (micro-MRI) is a non-destructive, quantitative and inherently 3D imaging method for analyzing mouse embryos.  ...  Taken together, these results demonstrate that MPIO labeling and micro-MRI provide an efficient and powerful approach for analyzing 3D cell migration patterns in the normal and mutant mouse embryonic brain  ...  Marc Fuccillo and Gordon Fishell for advice on MGE/LGE cell migration and assistance with the immunohistochemistry.  ... 
doi:10.1016/j.neuroimage.2015.04.010 pmid:25869862 pmcid:PMC4446241 fatcat:6c34trlnzjbz3okoizpghdiecq

Diffusion MR Microscopy of Cortical Development in the Mouse Embryo

M. Aggarwal, I. Gobius, L. J. Richards, S. Mori
2014 Cerebral Cortex  
In this study, high-resolution 3D diffusion magnetic resonance (dMR) microscopy of the embryonic mouse cortex is presented.  ...  With the high-resolution 3D data of the mouse embryo, we were able to visualize the complex microstructure of embryonic cerebral tissue and to resolve its regional and temporal evolution during cortical  ...  Funding This work was supported by the National Institutes of Health (grants R01AG020012 and R01EB003543 to S.M.) and National Health and Medical Research Council (NHMRC) (grants APP1043045 and APP1048849  ... 
doi:10.1093/cercor/bhu006 pmid:24518754 pmcid:PMC4459293 fatcat:yyh732bybre25nkd6yfsbpvggm

Magnetic Resonance Diffusion Tensor Microimaging Reveals a Role for Bcl-x in Brain Development and Homeostasis

J. Zhang
2005 Journal of Neuroscience  
The technique was used to analyze the phenotype of conditional Bcl-x knock-out mice, in which the bcl-x gene was deleted specifically in neurons of the cerebral cortex and hippocampus beginning at embryonic  ...  Affected brain regions and associated axonal tracts showed severe atrophy in adult Bcl-x-deficient mice.  ...  Recently, we and other groups have demonstrated that magnetic resonance (MR) diffusion tensor microimaging (DTI) can non-invasively delineate the neuroanatomy of developing brains and capture embryonic  ... 
doi:10.1523/jneurosci.4129-04.2005 pmid:15728827 fatcat:lkrxoulwlbdi5ngmwqienfndau

A diffusion MRI-based spatiotemporal continuum of the embryonic mouse brain for probing gene–neuroanatomy connections

Dan Wu, Linda J. Richards, Zhiyong Zhao, Zuozhen Cao, Wanrong Luo, Wei Shao, Song-Hai Shi, Michael I. Miller, Susumu Mori, Seth Blackshaw, Jiangyang Zhang
2022 Proceedings of the National Academy of Sciences of the United States of America  
Here, we present a four-dimensional (4D) spatiotemporal continuum of the embryonic mouse brain from E10.5 to E15.5 reconstructed from diffusion magnetic resonance microscopy (dMRM) data.  ...  The embryonic mouse brain undergoes drastic changes in establishing basic anatomical compartments and laying out major axonal connections of the developing brain.  ...  of China (61801424, 81971606, 82122032, D.W.), and The Leading Innovation and Entrepreneurship Team of Zhejiang Province (202006140, D.W.).  ... 
doi:10.1073/pnas.2111869119 pmid:35165149 pmcid:PMC8851557 fatcat:mjqavo4c75bo3cocdcohhxk5be

Magnetic Resonance-Based Imaging in Animal Models of Fetal Alcohol Spectrum Disorder

Shonagh K. O'Leary-Moore, Scott E. Parnell, Robert J. Lipinski, Kathleen K. Sulik
2011 Neuropsychology Review  
Consideration is also given to the promise of methodological advances to allow in vivo studies of aberrant brain and behavior relationships in model animals and to the translational nature of this work  ...  Magnetic resonance imaging (MRI) techniques, such as magnetic resonance microscopy (MRM), diffusion tensor imaging (DTI), and magnetic resonance spectroscopy (MRS), have recently been applied to the study  ...  This work is supported by National Institutes of Health NIAAA grants AA007573, P60 AA011605, U01 AA017124; NCRR/NCI grants P41 05959 and U24 CA0292656 and NICDH 03110 and was conducted in conjunction with  ... 
doi:10.1007/s11065-011-9164-z pmid:21445552 pmcid:PMC3445286 fatcat:22tcfyi3vjfcpaoizms36bzawy

Small animal neuroimaging using magnetic resonance microscopy

E.T Ahrens, P.T Narasimhan, T Nakada, R.E Jacobs
2002 Progress in nuclear magnetic resonance spectroscopy  
Introduction Magnetic resonance imaging (MRI) provides threedimensional (3D) non-invasive views into optically opaque tissues with exquisite sensitivity to the local physical and chemical environments.  ...  Fig. 7 . 7 The i-MQC images of a ®xed mouse brain were obtained with a 11.7 T micro-imaging system. (A) shows the i-ZQC image of the mouse brain and (B) depicts the i-DQC image.  ... 
doi:10.1016/s0079-6565(02)00003-1 fatcat:twvecdhoyjbyvec4mfc5k4lt24

Engineered Mitochondrial Ferritin as a Magnetic Resonance Imaging Reporter in Mouse Olfactory Epithelium

Bistra Iordanova, T. Kevin Hitchens, Clinton S. Robison, Eric T. Ahrens, Juri G. Gelovani
2013 PLoS ONE  
We used this new reporter to image in vivo and ex vivo the gene expression in native olfactory sensory neurons in the mouse epithelium.  ...  We report the design of a MRI reporter gene with applications to non-invasive molecular imaging. We modified mitochondrial ferritin to localize to the cell cytoplasm.  ...  Acknowledgments We thank Ken Hovis for help with the experimental design, Nathan Urban for critical comments, and Lisa Pusateri and Hongyan Xu for technical assistance.  ... 
doi:10.1371/journal.pone.0072720 pmid:24023635 pmcid:PMC3758330 fatcat:ov4cmmvaqfggzm7h6dylpv3lra

Principles of Diffusion Tensor Imaging and Its Applications to Basic Neuroscience Research

Susumu Mori, Jiangyang Zhang
2006 Neuron  
The brain contains more than 100 billion neurons that communicate with each other via axons for the formation of complex neural networks.  ...  mouse embryonic development.  ...  Studies presented in this review are supported by the National Institute of Health RR15241, AG20012, EB003543, and ES012665.  ... 
doi:10.1016/j.neuron.2006.08.012 pmid:16950152 fatcat:xzr3xwfpefbhphx5ze2sxyvpye

Axonal Growth and Guidance Defects in Frizzled3 Knock-Out Mice: A Comparison of Diffusion Tensor Magnetic Resonance Imaging, Neurofilament Staining, and Genetically Directed Cell Labeling

Y. Wang
2006 Journal of Neuroscience  
This work demonstrates the usefulness of DTI and genetically directed neuronal labeling for the analysis of nervous system defects in the mouse.  ...  (1) diffusion tensor magnetic resonance imaging (DTI), (2) neurofilament staining, and (3) two genetically directed neuronal labeling methods.  ...  The first of these methods is magnetic resonance (MR) diffusion tensor microimaging (DTI) (Jacobs et al., 1999; Mori et al., 2001) .  ... 
doi:10.1523/jneurosci.3221-05.2006 pmid:16407530 fatcat:bn3lutuucfbfnc2v7htn7u5gl4

Functional Brain Imaging [chapter]

2013 Encyclopedia of Pain  
The brain contains more than 100 billion neurons that communicate with each other via axons for the formation of complex neural networks.  ...  mouse embryonic development.  ...  Studies presented in this review are supported by the National Institute of Health RR15241, AG20012, EB003543, and ES012665.  ... 
doi:10.1007/978-3-642-28753-4_200837 fatcat:qm7mtwguwbfo7j22toqx43osye

Characterization of the ventricular-subventricular stem cell niche during human brain development

Amanda M. Coletti, Deepinder Singh, Saurabh Kumar, Tasnuva Nuhat Shafin, Patrick J. Briody, Benjamin F. Babbitt, Derek Pan, Emily S. Norton, Eliot C. Brown, Kristopher T. Kahle, Marc R. Del Bigio, Joanne C. Conover
2018 Development  
However, reorganization of the V-SVZ stem cell niche and its relationship to ependymogenesis has not been characterized in the human brain.  ...  Based on comprehensive comparative spatiotemporal analyses of cytoarchitectural changes along the mouse and human ventricle surface, we uncovered a distinctive stem cell retention pattern in humans as  ...  NDAR is a collaborative informatics system created by the National Institutes of Health to provide a national resource to support and accelerate research in autism.  ... 
doi:10.1242/dev.170100 pmid:30237244 pmcid:PMC6215394 fatcat:lgj54xefsndxtcp7rdj4ibhhmy

Nanotechnologies for the study of the central nervous system

A. Ajetunmobi, A. Prina-Mello, Y. Volkov, A. Corvin, D. Tropea
2014 Progress in Neurobiology  
The authors would also like to thank Alexandra Tuzova for her assistance in the preparation of illustrations for this publication.  ...  Acknowledgements The authors would like to acknowledge financial support from Molecular Medicine Ireland (MMI) and the Higher Education Authority Cycle 5 Programme for Research in Third-Level Institutions  ...  The nanoparticles were conjugated with polyethylene glycol (PEG) to improve BBB permeability and injected intravenously into the right femoral brain, followed by magnetic resonance microimaging.  ... 
doi:10.1016/j.pneurobio.2014.09.004 pmid:25291406 fatcat:w2rst5c5dncb3jc5e5ofnyvega

Neuronal-Specific TUBB3 Is Not Required for Normal Neuronal Function but Is Essential for Timely Axon Regeneration

Alban Latremoliere, Long Cheng, Michelle DeLisle, Chen Wu, Sheena Chew, Elizabeth B. Hutchinson, Andrew Sheridan, Chloe Alexandre, Frederic Latremoliere, Shu-Hsien Sheu, Sara Golidy, Takao Omura (+9 others)
2018 Cell Reports  
In Brief Latremoliere et al. show that the neuronal-specific tubulin isoform TUBB3 is not required for normal development and function of the nervous system.  ...  We generated a knockout mouse for the neuronalspecific β-tubulin isoform Tubb3 to investigate its role in nervous system formation and maintenance.  ...  absence of neuronal migration or axonal guidance defects in Tubb3 −/− mice.  ... 
doi:10.1016/j.celrep.2018.07.029 pmid:30110642 pmcid:PMC6155462 fatcat:5leg6ohvkbarrbajmumljgfpv4

Atoh1 Inhibits Neuronal Differentiation and Collaborates with Gli1 to Generate Medulloblastoma-Initiating Cells

O. Ayrault, H. Zhao, F. Zindy, C. Qu, C. J. Sherr, M. F. Roussel
2010 Cancer Research  
cerebellum and transplanted back into the brains of naïve mice.  ...  The morphogen and mitogen Sonic Hedgehog (Shh) activates a Gli1-dependent transcription program that drives proliferation of granule neuron progenitors (GNP) within the external germinal layer of the postnatally  ...  Acknowledgments We thank Mary-Elizabeth Hatten, Michael Dyer, and Suzanne Baker for constructive criticisms of the manuscript; Jerold Rehg, Dorothy Bush, and David Elisson for immunohistochemistry and  ... 
doi:10.1158/0008-5472.can-09-3740 pmid:20516124 pmcid:PMC2896438 fatcat:7zxma2h4m5gr3ezfn3dfjsajyy

Analysis of homozygous and heterozygous Csf1r knockout in the rat as a model for understanding microglial function in brain development and the impacts of human CSF1R mutations

Omkar L. Patkar, Melanie Caruso, Ngari Teakle, Sahar Keshvari, Stephen J. Bush, Clare Pridans, Arnauld Belmer, Kim M. Summers, Katharine M. Irvine, David A. Hume
2021 Neurobiology of Disease  
Here we describe the impacts of Csf1r mutation in the rat on development of the brain.  ...  Mutations in the human CSF1R gene have been associated with dominant and recessive forms of neurodegenerative disease.  ...  Nyoman Kurniawan from the UQ Centre of Advanced Imaging for assistance with diffusion weighted imaging and Dr. Dhanisha Jhaveri and Mr. Saurabh Bandhavkar for advice on antibody staining.  ... 
doi:10.1016/j.nbd.2021.105268 pmid:33450391 pmcid:PMC7941205 fatcat:gnk3jnl4abennnirdg2vto23gi
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