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3-D Rat Brain Phantom for High-Resolution Molecular Imaging

F.J. Beekman, B. Vastenhouw, G. van der Wilt, M. Vervloet, R. Visscher, J. Booij, M. Gerrits, Changguo Ji, R. Ramakers, F. van der Have
2009 Proceedings of the IEEE  
Therefore, this newly developed brain phantom will enable the optimization of high-resolution imaging for recovery of complex shaped molecular distributions.  ...  We present a three-dimensional (3-D) digital and physical phantom pair to represent, e.g., cerebral blood flow, glucose metabolism, or neuroreceptor binding in small regions of the rat brain.  ...  .: 3-D Rat Brain Phantom for High-Resolution Molecular Imaging  ... 
doi:10.1109/jproc.2009.2028363 fatcat:mdrsxn24rjfktew72gjeugv2tu

Ultrahigh-resolution Cerenkov-light imaging system for positron radionuclides: potential applications and limitations

Seiichi Yamamoto, Tadashi Watabe, Hayato Ikeda, Yasukazu Kanai, Hiroshi Watabe, Yoshimune Ogata, Katsuhiko Kato, Jun Hatazawa
2014 Annals of Nuclear Medicine  
However, the magnitude for the high spatial resolution of Cerenkov-light imaging is unclear. Its potential molecular imaging applications also remain unclear.  ...  For applications of Cerenkov-light imaging, we conducted 18 F-FDG administered in vivo, ex vivo whole brain, and sliced brain imaging of rats.  ...  At 120 min, we obtained a high-resolution image of the phantom. 3. Imaging of small animals We show Cerenkov-light images of the tumor model rat in Fig. 10 .  ... 
doi:10.1007/s12149-014-0892-z pmid:25103137 pmcid:PMC4483184 fatcat:hx32edo6srhftgdem4aqtellyu

Small-Animal PET: A Technology That Changed Our Field

Yuan-Chuan Tai
2020 Journal of Nuclear Medicine  
This high resolution is realized for a diameter large enough to cover the bodies of mice and rats or the brains of small nonhuman primates.  ...  and 4.1 kcps at 296 kBq/mL (8 mCi/mL) for the rat body phantom, compared with 9.9 kcps at 667 kBq/mL (18 mCi/mL) for the cat brain phantom.  ... 
doi:10.2967/jnumed.120.251280 pmid:33293436 fatcat:4nplp6pzn5f5niu43klgeabj2u

Comparison of 3-D maximum a posteriori and filtered backprojection algorithms for high-resolution animal imaging with microPET

A. Chatziioannou, J. Qi, A. Moore, A. Annala, K. Nguyen, R. Leahy, S.R. Cherry
2000 IEEE Transactions on Medical Imaging  
Sixty independent realizations of a phantom simulating the brain of a baby monkey were acquired, each containing 3 million counts.  ...  We have evaluated the performance of two three dimensional reconstruction algorithms with data acquired from microPET, a high resolution tomograph dedicated to small animal imaging.  ...  Michel, Ron Sumida, Judy Edwards, Derjenn Liu, Waldemar Ladno, Dan Rubins and the staff of the UCLA biomedical cyclotron for providing the isotopes.  ... 
doi:10.1109/42.870260 pmid:11021693 fatcat:rgqw56lxjze4nepzljfamxnhva

PET imaging of freely moving interacting rats

Alan Miranda, Min Su Kang, Stephan Blinder, Reda Bouhachi, Jean-Paul Soucy, Arturo Aliaga-Aliaga, Gassan Massarweh, Sigrid Stroobants, Steven Staelens, Pedro Rosa-Neto, Jeroen Verhaeghe
2019 NeuroImage  
Awake rat imaging methodology based on point source tracking was adapted to be used in a dedicated human brain scanner, the ECAT high resolution research tomograph (HRRT).  ...  The developed methodology was validated using a motion resolution phantom experiment, 3 awake single rat [18F]FDG scans as well as an [18F]FDG scan of 2 interacting rats.  ...  In addition, this work was supported by the Weston Brain Institute, Canadian Institutes of Health Research (CIHR; MOP-11-51-31) (to P.R.N.), the Alzheimer's Association (NIRP-12-259245) (to P.R.N.), the  ... 
doi:10.1016/j.neuroimage.2019.02.064 pmid:30831313 fatcat:6rvgryirfzf2xhfbksvxybchzu

Semiconductor Detector-Based Scanners for Nuclear Medicine [chapter]

Wataru Takeuchi, Atsuro Suzuki, Yuichiro Ueno, Tohru Shiga, Kenji Hirata, Shozo Okamoto, Songji Zhao, Yuji Kuge, Naoki Kubo, Kentaro Kobayashi, Shiro Watanabe, Keiji Kobashi (+2 others)
2016 Perspectives on Nuclear Medicine for Molecular Diagnosis and Integrated Therapy  
The feasibility of using CdTe-SPECT for simultaneous dual-radionuclide imaging was evaluated through scans of phantoms and healthy volunteers.  ...  The fine energy resolution leads to a better image contrast due to better scatter rejection.  ...  Acknowledgments This work was supported in part by the Creation of Innovation Centers for Advanced Interdisciplinary Research Areas Program, Ministry of Education, Culture, Sports, Science and Technology  ... 
doi:10.1007/978-4-431-55894-1_4 fatcat:74kxs7tszrcnrkuekzr7fbfx5m

Maturation-dependent microstructure length scale in the corpus callosum of fixed rat brains by magnetic resonance diffusion–diffraction

Jun-Cheng Weng, Jyh-Horng Chen, Li-Wei Kuo, Van J. Wedeen, Wen-Yih I. Tseng
2007 Magnetic Resonance Imaging  
In conclusion, MR diffusion-diffraction can be observed in the corpus callosum of fixed rat brains. This technique might be useful in probing the status of myelination in the development of disease. D  ...  Although the magnetic resonance (MR) diffusion-diffraction technique has been proposed for years, its realization in an undissected brain has not been reported on.  ...  Der-Yow Chen and Pai-Feng Yang for their assistance in the animal experiments.  ... 
doi:10.1016/j.mri.2006.08.018 pmid:17222718 fatcat:uv7vsqfkzbgcjghdlylnwvy2ju

Image-based modelling of residual blurring in motion corrected small animal PET imaging using motion dependent point spread functions

G I Angelis, J E Gillam, A Z Kyme, R R Fulton, S R Meikle
2018 Biomedical engineering and physics express  
For motion typically encountered in an awake rat study, results showed that unprocessed motion corrected images suffer from lower resolution compared to a stationary acquisition.  ...  However, motion corrected images often exhibit reduced resolution when compared with their stationary counterparts.  ...  Head movements of a previously tracked awake tube-bound rat were converted to robot coordinates and applied to the hot rod phantom using a high precision 6-dof robot.  ... 
doi:10.1088/2057-1976/aab922 fatcat:cblgoj3qdncytg7dyphb2rjthm

Microbubbles as a novel contrast agent for brain MRI

Jerry S. Cheung, April M. Chow, Hua Guo, Ed X. Wu
2009 NeuroImage  
These results indicate that gas-filled microbubbles can serve as an intravascular contrast agent for brain MRI at high field.  ...  MRI in Sprague-Dawley rats at 7 T.  ...  Ke Xia Cai at the Laboratory of Biomedical Imaging and Signal Processing of the University of Hong Kong for assistance.  ... 
doi:10.1016/j.neuroimage.2009.02.037 pmid:19269337 fatcat:7dsvg5baobbpdaqyq3p5g7kj6a

Sheet-beam geometry for in vivo fluorescent x-ray computed tomography: proof-of-concept experiment in molecular imaging

Qingkai Huo, Tetsuya Yuasa, Takao Akatsuka, Tohoru Takeda, Jin Wu, Thet-Thet-Lwin, Kazuyuki Hyodo, F. Avraham Dilmanian
2008 Optics Letters  
We propose a fluorescent x-ray computed tomography (CT) method using an array of detectors with an incident sheet-beam, aimed at providing molecular imaging with high sensitivity and good spatial resolution  ...  In this study, we prove the feasibility of this concept and investigate its imaging properties including spatial and contrast resolutions and quantitativeness, by imaging an acrylic phantom and a normal  ...  Therefore, conventional FXCT cannot substitute for PET or SPECT, which can obtain 3-D tomographic images.  ... 
doi:10.1364/ol.33.002494 pmid:18978898 fatcat:ecjlky2vc5dajnh4katxewju6i

Development, integration and use of an ultra-high-strength gradient system on a human-size 3 T magnet for small animal MRI

Kuan-Hung Cho, Sheng-Min Huang, Chang-Hoon Choi, Ming-Jye Chen, Hsuan-Han Chiang, Richard P. Buschbeck, Ezequiel Farrher, N. Jon Shah, Ruslan Garipov, Ching-Ping Chang, Hsu Chang, Li-Wei Kuo (+1 others)
2019 PLoS ONE  
This study aims to integrate an ultra-high-strength gradient coil system on a clinical 3 T magnet and demonstrate its preclinical imaging capabilities.  ...  After careful tuning and calibration, we verified the accuracy and quantitative preclinical imaging capability of the integrated system in phantom and in vivo rat brain experiments.  ...  Piotr Starewicz for his generous technical support in the integration of the gradient coil system and the National Applied Research Laboratories for hardware support. Author Contributions  ... 
doi:10.1371/journal.pone.0217916 pmid:31158259 pmcid:PMC6546248 fatcat:fblwdyviifgibgqxfw7tyssfma

Sensitivity of Susceptibility-Weighted Imaging in Detecting Superparamagnetic Iron Oxide-Labeled Mesenchymal Stem Cells: A Comparative Study

Serah Park, Byung Kook Kwak, Jisung Jung
2015 Iranian Journal of Radiology  
However, no study has compared molecular imaging for stem cell detection using SWI and other MRI pulse sequences.  ...  SWI and T2*WI detected 15 µL of 13 SPIO-hMSCs/µL and 15 µL of 27 SPIO-hMSCs/µL in the phantom, respectively and 3 µL of 333 SPIO-hMSCs/µL and 3 µL of 167 SPIO-hMSCs/µL in the normal rat brain (direct implantation  ...  Direct Implantation into Normal Rat Brains SPIO-hMSC cell suspensions at two cell concentrations, i.e. 3 µL of 333 SPIO-hMSCs/µL in serum-free medium for the right brain and 3 µL of 167 SPIO-hMSCs/µL for  ... 
doi:10.5812/iranjradiol.20782 pmid:25901258 pmcid:PMC4389178 fatcat:kr6mnjlwdbbz3fghorkpaknwr4

Performance Evaluation of the Small-Animal nanoScan PET/MRI System

K. Nagy, M. Toth, P. Major, G. Patay, G. Egri, J. Haggkvist, A. Varrone, L. Farde, C. Halldin, B. Gulyas
2013 Journal of Nuclear Medicine  
nanoScan is a high-resolution integrated system for consecutive PET and MR imaging of small laboratory animals.  ...  We evaluated the performance of the system, using the NEMA NU 4-2008 protocol for the PET component and the NEMA MS 1-2007, MS 2-2008, and MS 3-2007 standards for the MR imaging component.  ...  We present 3D fast spin echo images of a rat and mouse brain in Figures 5A and 5B , respectively, and 3D spoiled gradient echo images of a rat in Figure 5C .  ... 
doi:10.2967/jnumed.112.119065 pmid:23990683 fatcat:5hz4iatg4jadbkleucpgnbrj2y

Validation of diffusion spectrum magnetic resonance imaging with manganese-enhanced rat optic tracts and ex vivo phantoms

Ching-Po Lin, Van Jay Wedeen, Jyh-Horng Chen, Ching Yao, Wen-Yih Isaac Tseng
2003 NeuroImage  
High-resolution T2-weighted images (T2WI) of the phantom served as a reference for the orientation of intersecting capillaries.  ...  In the in vivo model, manganese ions were infused into rats' optic tracts. The optic tracts were enhanced on T1-weighted images (T1WI) and served as a reference for the tract orientation.  ...  Keng-Chen Liang for their helpful advice to this study.  ... 
doi:10.1016/s1053-8119(03)00154-x pmid:12880782 fatcat:azgn6ustgjc5jayk67foa5x3gm

Targeted multi-pinhole SPECT

Woutjan Branderhorst, Brendan Vastenhouw, Frans van der Have, Erwin L. A. Blezer, Wim K. Bleeker, Freek J. Beekman
2010 European Journal of Nuclear Medicine and Molecular Imaging  
In order to assess the effects of more targeted imaging, scans of a resolution phantom and a mouse myocardial phantom, as well as in vivo mouse cardiac and tumour scans, were acquired with increased levels  ...  Scan planning with optical cameras provides an effective tool to exploit this principle without the necessity for additional X-ray CT imaging.  ...  ) for their help in designing and manufacturing the mouse myocardial phantom.  ... 
doi:10.1007/s00259-010-1637-4 pmid:21063706 pmcid:PMC3034876 fatcat:bcuujafsz5crro7b5q66xxgege
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