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3-D Rat Brain Phantom for High-Resolution Molecular Imaging
2009
Proceedings of the IEEE
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Therefore, this newly developed brain phantom will enable the optimization of high-resolution imaging for recovery of complex shaped molecular distributions. ...
We present a three-dimensional (3-D) digital and physical phantom pair to represent, e.g., cerebral blood flow, glucose metabolism, or neuroreceptor binding in small regions of the rat brain. ...
.: 3-D Rat Brain Phantom for High-Resolution Molecular Imaging ...
doi:10.1109/jproc.2009.2028363
fatcat:mdrsxn24rjfktew72gjeugv2tu
Ultrahigh-resolution Cerenkov-light imaging system for positron radionuclides: potential applications and limitations
2014
Annals of Nuclear Medicine
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However, the magnitude for the high spatial resolution of Cerenkov-light imaging is unclear. Its potential molecular imaging applications also remain unclear. ...
For applications of Cerenkov-light imaging, we conducted 18 F-FDG administered in vivo, ex vivo whole brain, and sliced brain imaging of rats. ...
At 120 min, we obtained a high-resolution image of the phantom. 3. Imaging of small animals We show Cerenkov-light images of the tumor model rat in Fig. 10 . ...
doi:10.1007/s12149-014-0892-z
pmid:25103137
pmcid:PMC4483184
fatcat:hx32edo6srhftgdem4aqtellyu
Small-Animal PET: A Technology That Changed Our Field
2020
Journal of Nuclear Medicine
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This high resolution is realized for a diameter large enough to cover the bodies of mice and rats or the brains of small nonhuman primates. ...
and 4.1 kcps at 296 kBq/mL (8 mCi/mL) for the rat body phantom, compared with 9.9 kcps at 667 kBq/mL (18 mCi/mL) for the cat brain phantom. ...
doi:10.2967/jnumed.120.251280
pmid:33293436
fatcat:4nplp6pzn5f5niu43klgeabj2u
Comparison of 3-D maximum a posteriori and filtered backprojection algorithms for high-resolution animal imaging with microPET
2000
IEEE Transactions on Medical Imaging
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Sixty independent realizations of a phantom simulating the brain of a baby monkey were acquired, each containing 3 million counts. ...
We have evaluated the performance of two three dimensional reconstruction algorithms with data acquired from microPET, a high resolution tomograph dedicated to small animal imaging. ...
Michel, Ron Sumida, Judy Edwards, Derjenn Liu, Waldemar Ladno, Dan Rubins and the staff of the UCLA biomedical cyclotron for providing the isotopes. ...
doi:10.1109/42.870260
pmid:11021693
fatcat:rgqw56lxjze4nepzljfamxnhva
PET imaging of freely moving interacting rats
2019
NeuroImage
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Awake rat imaging methodology based on point source tracking was adapted to be used in a dedicated human brain scanner, the ECAT high resolution research tomograph (HRRT). ...
The developed methodology was validated using a motion resolution phantom experiment, 3 awake single rat [18F]FDG scans as well as an [18F]FDG scan of 2 interacting rats. ...
In addition, this work was supported by the Weston Brain Institute, Canadian Institutes of Health Research (CIHR; MOP-11-51-31) (to P.R.N.), the Alzheimer's Association (NIRP-12-259245) (to P.R.N.), the ...
doi:10.1016/j.neuroimage.2019.02.064
pmid:30831313
fatcat:6rvgryirfzf2xhfbksvxybchzu
Semiconductor Detector-Based Scanners for Nuclear Medicine
[chapter]
2016
Perspectives on Nuclear Medicine for Molecular Diagnosis and Integrated Therapy
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The feasibility of using CdTe-SPECT for simultaneous dual-radionuclide imaging was evaluated through scans of phantoms and healthy volunteers. ...
The fine energy resolution leads to a better image contrast due to better scatter rejection. ...
Acknowledgments This work was supported in part by the Creation of Innovation Centers for Advanced Interdisciplinary Research Areas Program, Ministry of Education, Culture, Sports, Science and Technology ...
doi:10.1007/978-4-431-55894-1_4
fatcat:74kxs7tszrcnrkuekzr7fbfx5m
Maturation-dependent microstructure length scale in the corpus callosum of fixed rat brains by magnetic resonance diffusion–diffraction
2007
Magnetic Resonance Imaging
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In conclusion, MR diffusion-diffraction can be observed in the corpus callosum of fixed rat brains. This technique might be useful in probing the status of myelination in the development of disease. D ...
Although the magnetic resonance (MR) diffusion-diffraction technique has been proposed for years, its realization in an undissected brain has not been reported on. ...
Der-Yow Chen and Pai-Feng Yang for their assistance in the animal experiments. ...
doi:10.1016/j.mri.2006.08.018
pmid:17222718
fatcat:uv7vsqfkzbgcjghdlylnwvy2ju
Image-based modelling of residual blurring in motion corrected small animal PET imaging using motion dependent point spread functions
2018
Biomedical engineering and physics express
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For motion typically encountered in an awake rat study, results showed that unprocessed motion corrected images suffer from lower resolution compared to a stationary acquisition. ...
However, motion corrected images often exhibit reduced resolution when compared with their stationary counterparts. ...
Head movements of a previously tracked awake tube-bound rat were converted to robot coordinates and applied to the hot rod phantom using a high precision 6-dof robot. ...
doi:10.1088/2057-1976/aab922
fatcat:cblgoj3qdncytg7dyphb2rjthm
Microbubbles as a novel contrast agent for brain MRI
2009
NeuroImage
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These results indicate that gas-filled microbubbles can serve as an intravascular contrast agent for brain MRI at high field. ...
MRI in Sprague-Dawley rats at 7 T. ...
Ke Xia Cai at the Laboratory of Biomedical Imaging and Signal Processing of the University of Hong Kong for assistance. ...
doi:10.1016/j.neuroimage.2009.02.037
pmid:19269337
fatcat:7dsvg5baobbpdaqyq3p5g7kj6a
Sheet-beam geometry for in vivo fluorescent x-ray computed tomography: proof-of-concept experiment in molecular imaging
2008
Optics Letters
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We propose a fluorescent x-ray computed tomography (CT) method using an array of detectors with an incident sheet-beam, aimed at providing molecular imaging with high sensitivity and good spatial resolution ...
In this study, we prove the feasibility of this concept and investigate its imaging properties including spatial and contrast resolutions and quantitativeness, by imaging an acrylic phantom and a normal ...
Therefore, conventional FXCT cannot substitute for PET or SPECT, which can obtain 3-D tomographic images. ...
doi:10.1364/ol.33.002494
pmid:18978898
fatcat:ecjlky2vc5dajnh4katxewju6i
Development, integration and use of an ultra-high-strength gradient system on a human-size 3 T magnet for small animal MRI
2019
PLoS ONE
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This study aims to integrate an ultra-high-strength gradient coil system on a clinical 3 T magnet and demonstrate its preclinical imaging capabilities. ...
After careful tuning and calibration, we verified the accuracy and quantitative preclinical imaging capability of the integrated system in phantom and in vivo rat brain experiments. ...
Piotr Starewicz for his generous technical support in the integration of the gradient coil system and the National Applied Research Laboratories for hardware support.
Author Contributions ...
doi:10.1371/journal.pone.0217916
pmid:31158259
pmcid:PMC6546248
fatcat:fblwdyviifgibgqxfw7tyssfma
Sensitivity of Susceptibility-Weighted Imaging in Detecting Superparamagnetic Iron Oxide-Labeled Mesenchymal Stem Cells: A Comparative Study
2015
Iranian Journal of Radiology
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However, no study has compared molecular imaging for stem cell detection using SWI and other MRI pulse sequences. ...
SWI and T2*WI detected 15 µL of 13 SPIO-hMSCs/µL and 15 µL of 27 SPIO-hMSCs/µL in the phantom, respectively and 3 µL of 333 SPIO-hMSCs/µL and 3 µL of 167 SPIO-hMSCs/µL in the normal rat brain (direct implantation ...
Direct Implantation into Normal Rat Brains SPIO-hMSC cell suspensions at two cell concentrations, i.e. 3 µL of 333 SPIO-hMSCs/µL in serum-free medium for the right brain and 3 µL of 167 SPIO-hMSCs/µL for ...
doi:10.5812/iranjradiol.20782
pmid:25901258
pmcid:PMC4389178
fatcat:kr6mnjlwdbbz3fghorkpaknwr4
Performance Evaluation of the Small-Animal nanoScan PET/MRI System
2013
Journal of Nuclear Medicine
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nanoScan is a high-resolution integrated system for consecutive PET and MR imaging of small laboratory animals. ...
We evaluated the performance of the system, using the NEMA NU 4-2008 protocol for the PET component and the NEMA MS 1-2007, MS 2-2008, and MS 3-2007 standards for the MR imaging component. ...
We present 3D fast spin echo images of a rat and mouse brain in Figures 5A and 5B , respectively, and 3D spoiled gradient echo images of a rat in Figure 5C . ...
doi:10.2967/jnumed.112.119065
pmid:23990683
fatcat:5hz4iatg4jadbkleucpgnbrj2y
Validation of diffusion spectrum magnetic resonance imaging with manganese-enhanced rat optic tracts and ex vivo phantoms
2003
NeuroImage
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High-resolution T2-weighted images (T2WI) of the phantom served as a reference for the orientation of intersecting capillaries. ...
In the in vivo model, manganese ions were infused into rats' optic tracts. The optic tracts were enhanced on T1-weighted images (T1WI) and served as a reference for the tract orientation. ...
Keng-Chen Liang for their helpful advice to this study. ...
doi:10.1016/s1053-8119(03)00154-x
pmid:12880782
fatcat:azgn6ustgjc5jayk67foa5x3gm
Targeted multi-pinhole SPECT
2010
European Journal of Nuclear Medicine and Molecular Imaging
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In order to assess the effects of more targeted imaging, scans of a resolution phantom and a mouse myocardial phantom, as well as in vivo mouse cardiac and tumour scans, were acquired with increased levels ...
Scan planning with optical cameras provides an effective tool to exploit this principle without the necessity for additional X-ray CT imaging. ...
) for their help in designing and manufacturing the mouse myocardial phantom. ...
doi:10.1007/s00259-010-1637-4
pmid:21063706
pmcid:PMC3034876
fatcat:bcuujafsz5crro7b5q66xxgege
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