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3 T MRI relaxometry detects T2 prolongation in the cerebral normal-appearing white matter in multiple sclerosis

Mohit Neema, Daniel Goldberg-Zimring, Zachary D. Guss, Brian C. Healy, Charles R.G. Guttmann, Maria K. Houtchens, Howard L. Weiner, Mark A. Horsfield, David B. Hackney, David C. Alsop, Rohit Bakshi
2009 NeuroImage  
MRI at 3 T has increased sensitivity in detecting overt multiple sclerosis (MS) brain lesions; a growing body of data suggests clinically relevant damage occurs in the normal-appearing white matter (NAWM  ...  We tested a novel pulse sequence to determine whether 3 T MRI spin-spin relaxometry detected damage in NAWM of MS patients (n = 13) vs. age-matched normal controls [(NL) (n = 11)].  ...  Acknowledgments This work was supported by research grants from the National Institutes of Health (NIH-NINDS K23 NS42379-01 and R01 NS055083-01) and National Multiple Sclerosis Society (RG3705A1; RG3798A2  ... 
doi:10.1016/j.neuroimage.2009.03.001 pmid:19281850 pmcid:PMC2974316 fatcat:fkovwux25fbkfle6pi5kdendce

Partial epilepsy: A pictorial review of 3 TESLA magnetic resonance imaging features

LG Abud, L Thivard, TG Abud, GS Nakiri, AC Santos, D Dormont
2015 Clinics  
Several studies have shown that 3 Tesla (T) MRI provides a better image quality than 1.5 T MRI regarding the detection and characterization of structural lesions, indicating that high-field-strength imaging  ...  We present a pictorial review of the major pathologies related to partial epilepsy, highlighting the key findings of 3 T MRI.  ...  Initial imaging can be normal; over time, however, T2 prolongation appears in the cerebral cortex and subcortical white matter on MRI.  ... 
doi:10.6061/clinics/2015(09)10 pmid:26375569 pmcid:PMC4557590 fatcat:ehsowumtb5gnxoxybv4dpbqqhi

Quantitative 7T MRI does not detect occult brain damage in neuromyelitis optica

Baptiste Pasquier, Nadja Borisow, Ludwig Rasche, Judith Bellmann-Strobl, Klemens Ruprecht, Thoralf Niendorf, Tobias J. Derfuss, Jens Wuerfel, Friedemann Paul, Tim Sinnecker
2019 Neurology: Neuroimmunology & Neuroinflammation  
sclerosis (MS) applying quantitative T1 mapping at 7 Tesla (T) in a cross-sectional study.  ...  To investigate and compare occult damages in aquaporin-4 (AQP4)-rich periependymal regions in patients with neuromyelitis optica spectrum disorder (NMOSD) vs healthy controls (HCs) and patients with multiple  ...  Figure 1 Segmentation of the normal-appearing periependymal white matter The figure demonstrates the procedure to segment the normal-appearing periependymal white matter.  ... 
doi:10.1212/nxi.0000000000000541 pmid:30882018 pmcid:PMC6410932 fatcat:pr5ycr6zr5e6fpnd57uuo3gx7m

MRI in multiple sclerosis: What's inside the toolbox?

Mohit Neema, James Stankiewicz, Ashish Arora, Zachary D. Guss, Rohit Bakshi
2007 Neurotherapeutics  
Magnetic resonance imaging (MRI) has played a central role in the diagnosis and management of multiple sclerosis (MS).  ...  These measures are particularly useful in revealing diffuse damage in cerebral white and gray matter and therefore may help resolve the dissociation between clinical and conventional MRI findings.  ...  Bakshi from the National Institutes of Health (NIH-NINDS 1 K23 NS42379-01) and National Multiple Sclerosis Society (RG3705A1; RG3798A2). We thank Ms. Sophie Tamm for her editorial assistance.  ... 
doi:10.1016/j.nurt.2007.08.001 pmid:17920541 fatcat:m7eqrjeqbvfylke5qn4xes65im

Magnetic resonance fingerprinting of temporal lobe white matter in mesial temporal lobe epilepsy

Kang Wang, Xiaozhi Cao, Dengchang Wu, Congyu Liao, Jianfang Zhang, Caihong Ji, Jianhui Zhong, Hongjian He, Yanxing Chen
2019 Annals of Clinical and Translational Neurology  
We aimed to quantify the white matter alterations in the temporal lobe of MTLE patients with hippocampal sclerosis (MTLE-HS) by using magnetic resonance fingerprinting (MRF), a novel imaging technique,  ...  which allows simultaneous measurements of multiple parameters with a single acquisition.  ...  Conflicts of Interests The authors have no financial conflicts of interest.  ... 
doi:10.1002/acn3.50851 pmid:31359636 pmcid:PMC6764497 fatcat:youc5mlblve6zay6aj76qlbcua


Vijaya Kumari M, Aswini Jyothi J S, Suman Chandra A, Pushpanjali V, Jayalatha N
2017 Journal of Evolution of Medical and Dental Sciences  
To identify structural abnormalities in the brain associated with Epilepsy. 2. To study the spectrum of MRI findings in patients with Epilepsy. 3. To study the aetiological factors of Epilepsy. 4.  ...  To evaluate the diagnostic efficacy of a standard MRI of the brain in children with epilepsy.  ...  imaging (tuberous sclerosis), 3) Normal MRI with abnormal EEG.  ... 
doi:10.14260/jemds/2017/107 fatcat:zegdt3hlwna37ecqsnaf7qzjqi

Narrative review of epilepsy: getting the most out of your neuroimaging

Andrea De Vito, Kshitij Mankad, Suresh Pujar, Aswin Chari, Davide Ippolito, Felice D'Arco
2021 Translational Pediatrics  
Recent advances in MRI acquisitions including diffusion-weighted imaging (DWI), post-acquisition image processing techniques, and quantification of imaging data are increasing the accuracy of lesion detection  ...  Morphological qualitative imaging shows the majority of cerebral lesions/alterations underlying focal epilepsy and can highlight some features which are useful in the differential diagnosis of the different  ...  MRI findings are represented by serpiginous flow voids with areas of T2 prolongation in the adjacent brain parenchyma in T1-WI and T2-WI.  ... 
doi:10.21037/tp-20-261 pmid:34012857 pmcid:PMC8107872 fatcat:tcotxfeu7zaudcovmpj2zngdiq

Imaging in epilepsy

T M Salmenpera
2005 Journal of Neurology, Neurosurgery and Psychiatry  
In focal cortical dysplasia (FCD) the key MRI findings are focal cortical thickening, simplified gyration, blurring of the cortical-white matter junction, and T2 prolongation in the underlying white matter  ...  Figure 3 3 Dysembryoplastic neuroepithelial tumour on the left (coronal 3.0 T MRI). (A) T2 weighted FLAIR image. (B) Dual echo late echo image (TE 120).  ... 
doi:10.1136/jnnp.2005.075135 pmid:16107387 pmcid:PMC1765703 fatcat:udko7bltifgjxllxj6ucd3zocu

Quantitative MRI data in Multiple Sclerosis patients: a pattern recognition study

Rodrigo Antonio Pessini, Antonio Carlos dos Santos, Carlos Ernesto Garrido Salmon
2018 Research on Biomedical Engineering  
Methods: The data came from the combination of computational tools of image processing and neuroimaging acquired in a 3 Tesla scanner using different techniques: Diffusion, T2 Relaxometry, Magnetization  ...  Multiple Sclerosis (MS) is a neurodegenerative disease characterized by inflammatory demyelination in the central nervous system.  ...  Acknowledgements The authors are grateful to funding agencies CNPq (grant number 311703/2014-3) and FAPESP (process 05/56447-7). We also thank Dr.  ... 
doi:10.1590/2446-4740.07117 fatcat:euiytqxykbd5dposuyoxmafcd4

Brain abnormalities in cognition, anxiety, and depression regulatory regions in adolescents with single ventricle heart disease

Nancy A. Pike, Bhaswati Roy, Ritika Gupta, Sadhana Singh, Mary A. Woo, Nancy J. Halnon, Alan B. Lewis, Rajesh Kumar
2018 Journal of Neuroscience Research  
white matter, corpus callosum, brainstem, and cerebellar areas.  ...  We examined brain tissue changes in SVHD compared to controls using T2-relaxometry procedures, which measure free water content and show tissue injury.  ...  Funding information: This research was supported by the National Institutes of Health, grant numbers: R01-NR013930 and R01-NR016463.  ... 
doi:10.1002/jnr.24215 pmid:29315714 pmcid:PMC6103299 fatcat:ntgcx4orircgnlrhgljvlupxeq

Magnetic resonance T2-relaxometry and 2D L-correlated spectroscopy in patients with minimal hepatic encephalopathy

Aparna Singhal, Rajakumar Nagarajan, Rajesh Kumar, Amir Huda, Rakesh K. Gupta, M. Albert Thomas
2009 Journal of Magnetic Resonance Imaging  
Conclusion-MHE patients showed significantly increased T 2 values in multiple brain regions reflecting increased free water content and T 2 values in frontal lobe correlated with the increased Glx/Cr_d  ...  Purpose-To evaluate T 2 -relaxation changes in patients with minimal hepatic encephalopathy (MHE) using T 2 -relaxometry and to correlate T 2 values with brain metabolites evaluated using two-dimensional  ...  Acknowledgments Authors would like to acknowledge the scientific support of Dr. Steve Han, Dr. Virginia Elderkin-Thompson, and Dr. Nader Binesh.  ... 
doi:10.1002/jmri.21943 pmid:19856435 pmcid:PMC2853893 fatcat:nn6ei4ebezaibfenqkbj2c53zu

Regional brain tissue changes in patients with cystic fibrosis

Bhaswati Roy, Marlyn S. Woo, Susana Vacas, Patricia Eshaghian, Adupa P. Rao, Rajesh Kumar
2021 Journal of Translational Medicine  
Our aim was to assess regional brain changes using high-resolution T1-weighted images based gray matter (GM) density and T2-relaxometry procedures in CF over control subjects.  ...  Using PD- and T2-weighted images, whole-brain T2-relaxation maps were calculated, normalized, and smoothed.  ...  Acknowledgements The authors would like to thank Mr. Luke Ehlert for help in data collection.  ... 
doi:10.1186/s12967-021-03092-x pmid:34627274 pmcid:PMC8502335 fatcat:z2g2lim35zhevmiohibnbno7mq

In Vivo Imaging of Human Neuroinflammation

Daniel S. Albrecht, Cristina Granziera, Jacob M. Hooker, Marco L. Loggia
2016 ACS Chemical Neuroscience  
Neuroinflammation is implicated in the pathophysiology of a growing number of human disorders, including multiple sclerosis, chronic pain, traumatic brain injury, and amyotrophic lateral sclerosis.  ...  MRI), and (4) pathological consequences of neuroinflammation (e.g. imaging apoptosis with [(99m)Tc]Annexin V or iron accumulation with T2* relaxometry).  ...  Eva Ratai for helpful feedback on the manuscript.  ... 
doi:10.1021/acschemneuro.6b00056 pmid:26985861 pmcid:PMC5433433 fatcat:gqhfim2wgnannf4jwg3tvbqvz4

Rapid simultaneous high-resolution mapping of myelin water fraction and relaxation times in human brain using BMC-mcDESPOT

Mustapha Bouhrara, Richard G. Spencer
2017 NeuroImage  
SRC estimates of the transverse relaxation time of the long T 2 fraction, T 2,l , and the longitudinal relaxation time of the short T 1 fraction, T 1,s , clustered towards the lower and upper parameter  ...  A number of central nervous system (CNS) diseases exhibit changes in myelin content and magnetic resonance longitudinal, T 1 , and transverse, T 2 , relaxation times, which therefore represent important  ...  Acknowledgments This work was supported by the Intramural Research Program of the NIH, National Institute on Aging. We thank David A.  ... 
doi:10.1016/j.neuroimage.2016.09.064 pmid:27729276 pmcid:PMC5303643 fatcat:44iczxemv5cddiuuos2sy2zsry

Magnetic Resonance Imaging in Multiple Sclerosis

Christopher C. Hemond, Rohit Bakshi
2018 Cold Spring Harbor Perspectives in Medicine  
ACKNOWLEDGMENTS The authors thank the following team members from Dr. Bakshi's laboratory for preparing Fig-  ...  Typical multiple sclerosis (MS) white matter and gray matter lesions in the brain as shown by cerebral 3T magnetic resonance imaging (MRI).  ...  T1-weighted spin-echo images to detect white matter lesions in multiple sclerosis (MS). Cerebral 1.5T magnetic resonance imaging (MRI) scans showing typical MS findings.  ... 
doi:10.1101/cshperspect.a028969 pmid:29358319 fatcat:ytdy4yzrsbabnejyqbwof4nefe
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