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"Fluctuograms" Reveal the Intermittent Intra-Protein Communication in Subtilisin Carlsberg and Correlate Mechanical Coupling with Co-Evolution

Jordi Silvestre-Ryan, Yuchun Lin, Jhih-Wei Chu, Ruth Nussinov
2011 PLoS Computational Biology  
We illustrate that the Ca 2+ -bound and apo states of subtilisin have different fluctuograms and that intra-protein communication proceeds intermittently both in space and in time.  ...  The mechanism of intra-protein communication and allosteric coupling is key to understanding the structure-property relationship of protein function.  ...  Correlate fluctuograms with co-evolution The fluctuograms of Ca 2+ -bound and apo subtilisin illustrate the mechanism of intra-protein communication and show that residues surviving from random mutagenesis  ... 
doi:10.1371/journal.pcbi.1002023 pmid:21455286 pmcid:PMC3063751 fatcat:3dnuvifezbhprmcvrvsnkkffia