@misc{lin-moore_oyeyemi_hammarlund_2020, 
  title={rab-27 acts in an intestinal secretory pathway to inhibit axon regeneration in C. elegans}, 
  DOI={10.1101/2020.09.05.283267}, 
  abstractNote={<jats:p>Injured axons must regenerate to restore nervous system function, and regeneration is regulated in part by external factors from non-neuronal tissues. Many of these extrinsic factors act in the immediate cellular environment of the axon to promote or restrict regeneration, but the existence of long-distance signals regulating axon regeneration has not been clear. Here we show that the Rab GTPase <jats:italic>rab-27</jats:italic> inhibits regeneration of GABAergic motor neurons in <jats:italic>C. elegans</jats:italic> through activity in the intestine. Re-expression of RAB-27, but not the closely related RAB-3, in the intestine of <jats:italic>rab-27</jats:italic> mutant animals is sufficient to rescue normal regeneration. Several additional components of an intestinal neuropeptide secretion pathway also inhibit axon regeneration, including NPDC1/<jats:italic>cab-1</jats:italic>, SNAP25/<jats:italic>aex-4</jats:italic>, and KPC3/<jats:italic>aex-5</jats:italic>. Together these data indicate that RAB-27-dependent neuropeptide secretion from the intestine inhibits axon regeneration, and point to distal tissues as potent extrinsic regulators of regeneration.</jats:p>}, 
  publisher={Cold Spring Harbor Laboratory}, 
  author={Lin-Moore, Alexander T and Oyeyemi, Motunrayo J and Hammarlund, Marc}, 
  year={2020}, 
  month={Sep}
  }