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Delivery Systems in Ocular Retinopathies: The Promising Future of Intravitreal Hydrogels as Sustained-Release Scaffolds
release_zc6vnjo7zndkxju3l4pkftvoly
by
Diana Rafael,
Marcelo Guerrero,
Adolfo Marican,
Diego Arango,
Bruno Sarmento,
Roser Ferrer Costa,
Esteban F. Durán-Lara,
Simon J Clark,
Simo Schwartz
Abstract
Slow-release delivery systems are needed to ensure long-term sustained treatments for retinal diseases such as age-related macular degeneration and diabetic retinopathy, which are currently treated with anti-angiogenic agents that require frequent intraocular injections. These can cause serious co-morbidities for the patients and are far from providing the adequate drug/protein release rates and required pharmacokinetics to sustain prolonged efficacy. This review focuses on the use of hydrogels, particularly on temperature-responsive hydrogels as delivery vehicles for the intravitreal injection of retinal therapies, their advantages and disadvantages for intraocular administration, and the current advances in their use to treat retinal diseases.
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1999-4923
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