Einfluss von Ausdauertraining auf die Thrombozytenfunktion bei Rauchern release_z63julwo5reffah2hccdi74sp4

Abstract

The objective of this diploma was to assess the effects of regularly, aerobic endurance training on platelet function in smokers. 15 of the participating volunteers completed twelve weeks of training and finished the study. Change of platelet basal activation and agonist- (ADP) and antagonist- (PGE1) induced changes of platelet-sensitivity in succession of training were measured; as well as the effects of training on platelet adhesion and aggregation. Improvement of physical performance due to training was determined by spiroergometry: All performance parameters showed significant improvement and prove an increase in cardiopulmonary performance level. Platelet parameters were determined by flow cytometry and plate and cone analyzer Impact R. The following results were obtained: Platelet activation measured by P Selectin-expression was decreased after training. In particular, exercise induced platelet-resistance, especially at submaximal ADP-levels and platelet activitation decreased significantly. Basal activation of platelets was also significantly attenuated by training. Adhesion of platelets was diminished by training in a statistically significant way. This indicates lower platelet activation and affirms the results of P-Selectin-measured platelet function. Platelet Reactivity Index was reduced after training and indicates lower platelet reactivity; there may be a reduced respond of platelets to ADP and PGE1. In contrast to the results expected from the above mentioned effects, a statistically significant reduction of VASP phosphorylation after training (in principle indicating decreased platelet inhibition) was observed. The data of this study suggest that regularly performed aerobic endurance training reduces basal and induced platelet activation and might thereby prevent cardiovaskular disease in smokers.
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