@article{hashimoto_shoda_inoue_yamada_kondo_sakurai_ueno_muramatsu_1992, 
  title={Functional regulation of osteoblastic cells by the interaction of activin-A with follistatin}, 
  volume={267}, 
  abstractNote={A high number of 125I-activin-A binding sites (an apparent Kd of 260 pM and 5,600 sites/cell) were observed on MC3T3-E1 cells, a well characterized osteoblastic cell line. Activin-A has a mitogenic effect on these cells, with the greatest influence being observed on cells in an undifferentiated state, as well as a suppressive effect on the alkaline phosphatase activity. Northern and ligand blotting analyses revealed that these osteoblastic cells produce follistatin, which was down-regulated by retinoic acid treatment. Because follistatin is an activin-A-binding protein, we suggest that activin-A modulates the function of osteoblastic cells by being regulated by follistatin during differentiation.}, 
  number={7}, 
  author={Hashimoto, M and Shoda, A and Inoue, S and Yamada, R and Kondo, T and Sakurai, T and Ueno, N and Muramatsu, M}, 
  year={1992}, 
  month={Mar}
  }