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Cutaneous mast cell tumor in a captive Bush dog (Speothos venaticus): pathological and immunophenotypical aspects - case report
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by
Daniel Santos,
AYISA RODRIGUES DE OLIVEIRA,
Thaynara Parente de Carvalho,
Nayara Ferreira De Paula,
Herlandes Penha Tinoco,
Carlyle Coelho,
Angela Pessanha,
G.C. Martins,
Emerson Veloso,
Enio Ferreira,
Felipe Pierezan,
Renato de Lima Santos
Published
in Arquivo Brasileiro de Medicina Veterinária e Zootecnia
by FapUNIFESP (SciELO).
2021 Volume 73, p1099-1104
Abstract
ABSTRACT A senile male captive bush dog (Speothos venaticus) presented a small perianal cutaneous nodule. Histologically, there was an ulcerated round cell tumor composed of well differentiated mast cells with abundant intracytoplasmic purple Giemsa-positive granules, with a diffuse eosinophilic infiltrate. Immunohistochemistry revealed that 30% of the neoplastic cells were positive for Kit in the cytoplasm and cell membrane, and all neoplastic cells were negative for MAC and CD3. Less than 10% of the neoplastic cells were positive for Ki67. At necropsy other primary tumors were identified in this animal, including an intestinal adenoma, an adrenal cortex adenoma and a testicular interstitial cell tumor.
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