abstracts[] |
{'sha1': '1c888e21eabc089346421585dd417a6e00a8b592', 'content': 'Recent study was conducted to develop and validate analytical methods for estimation of\xa0Risedronate sodium in pure and pharmaceutical dosage form using UV Spectroscopy and\xa0\xa0\xa0\xa0\xa0\xa0\xa0\xa0\xa0\xa0\xa0\xa0\xa0\xa0\xa0RP- HPLC method.\xa0The first method (Method A)\xa0based on the UV Spectroscopy using\xa00.1M Hcl as diluent lambda max was found at 261 nm. Linearity existed perceived in the concentration between 10-50 μg/ml (r\xa02\xa0= 0.999) for the method. The method was validated pertaining to linearity, precision and accuracy studies, LOD and LOQ consistent with ICH guidelines.\xa0The second method (Method B), based on determination of\xa0Risedronate sodium tablet dosage form by RP-HPLC method.\xa0\xa0Chromatography separation was carried out on a\xa0C18\xa0(150X4.6 mm x5 µ) SS Column using Methanol: Ammonium formate (85:15) as the mobile phase at a flow rate of\xa0\xa0\xa01.0 ml/min.\xa0The chromatographic analysis was carried out in the reflectance and absorbance mode at 254 nm and retention time of the drug was found to be 1.11 ml/min for standard and tablet. Linear responses of the drug were in the concentration range of 200-1000\xa0µg/ml. The accuracy of the method was assessed by standard dilution method and found to be 98% to\xa0\xa0\xa0\xa0\xa0\xa0\xa0\xa0\xa0\xa0\xa0\xa0\xa0\xa0102%\xa0.The results of the analysis were validated statistically prism software.\xa0The method established was found to be simple, precise, linear, accurate and sensitive. The developed method can be used for routine quality control analysis of\xa0Risedronate sodium\xa0in pure and pharmaceutical dosage form.', 'mimetype': 'application/xml+jats', 'lang': None}
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{'index': 0, 'creator_id': None, 'creator': None, 'raw_name': 'Ananda Thangadurai Subramaniam', 'given_name': 'Ananda Thangadurai', 'surname': 'Subramaniam', 'role': 'author', 'raw_affiliation': None, 'extra': {'seq': 'first'}}
{'index': 1, 'creator_id': None, 'creator': None, 'raw_name': 'Devi Velmurugan', 'given_name': 'Devi', 'surname': 'Velmurugan', 'role': 'author', 'raw_affiliation': None, 'extra': None}
{'index': 2, 'creator_id': None, 'creator': None, 'raw_name': 'Sambathkumar Ramanathan', 'given_name': 'Sambathkumar', 'surname': 'Ramanathan', 'role': 'author', 'raw_affiliation': None, 'extra': None}
{'index': 3, 'creator_id': None, 'creator': None, 'raw_name': 'Kamalakannan Dhanabalan', 'given_name': 'Kamalakannan', 'surname': 'Dhanabalan', 'role': 'author', 'raw_affiliation': None, 'extra': None}
{'index': 4, 'creator_id': None, 'creator': None, 'raw_name': 'Jambulingam Munusamy', 'given_name': 'Jambulingam', 'surname': 'Munusamy', 'role': 'author', 'raw_affiliation': None, 'extra': None}
{'index': 5, 'creator_id': None, 'creator': None, 'raw_name': 'Hemanth Gampala', 'given_name': 'Hemanth', 'surname': 'Gampala', 'role': 'author', 'raw_affiliation': None, 'extra': None}
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Vensel Publications
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2019-12-17
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published
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article-journal
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2019
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title |
Development and validation of RP-HPLC/UV methods for the estimation of Risedronate sodium in pure and pharmaceutical dosage form
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