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Biologic activity of an idiotype-bearing suppressor T cell factor produced by a long-term T cell hybridoma.
release_wex4lhigcbfpfhg3w6lsmwnpkq
by
M Takaoki,
M S Sy,
B Whitaker,
J Nepom,
R Finberg,
R N Germain,
A Nisonoff,
B Benacerraf,
M I Greene
Published
in Journal of Immunology
by The American Association of Immunologists.
1982 Volume 128, p49-53
Abstract
<jats:title>Abstract</jats:title>
Biologic activities and immunochemical characteristics of an azobenzenearsonate- (ABA)specific suppressor T cell factor produced by a longterm T cell hybridoma, F12, were studied. In vivo administration of F12 culture supernatant resulted in the suppression of ABA-specific delayed-type hypersensitivity (DTH) responses and the inhibition of priming for ABA-specific cytotoxic T lymphocyte responses. Moreover, F12 induced a second set of suppressor cells that act in the efferent phase of DTH. The active material in the F12 culture supernatant expressed major cross-reactive idiotypic (CRI) determinants of anti-ABA antibodies of A/J mice and I-J subregion-coded specificities but not express determinants of immunoglobulin constant regions. These results demonstrated that F12 is a functioning hybrid cell line of the first-order suppressor T cell subset.
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