Effects of COXIB in Orthodontic Tooth Movement – A Literature Review release_vyo3yoib4vd2bc4xaefutc4kva

Abstract

Pain measurements help to determine the severity, type and duration of pain and are used to make an accurate diagnosis and evaluate the effectiveness of treatment. Pain relief can be achieved pharmacologically or non pharmacologically. Pharmacologically, NSAIDs are the drugs of choice. They act by inhibition of enzyme cyclooxygenase which mediates the transformation of prostaglandins from arachidonic acid in the cellular plasma membrane. PGs such as PGE and PGE2 are important mediators of bone resorption. COX – 1 is considered important in tissue homeostasis. COX – 2 is transcriptionally induced by cytokines and is important in the development of inflammation. Non pharmacological methods include application of low level laser therapy to periodontal tissues, Transcutaneous Electrical Nerve Stimulation and vibratory stimulation of periodontal ligament. All these methods are only partially successful in achieving pain relief. However, the use of NSAIDs is the preferred method for pain control related to fixed orthodontic appliances.<br> Orthodontic tooth movement is mainly a biological response to a mechanical force. Tooth movement is induced by prolonged application of controlled mechanical forces which creates pressure and tension zones in the periodontal ligament and alveolar bone causing remodeling of tooth sockets. When a tooth is moved by application of orthodontic force, there is bone resorption on the pressure side and new bone formation on the tension side. Orthodontists often prescribe NSAIDs to manage pain from force application. However NSAIDs block prostaglandin synthesis and results in slower tooth movement. NSAIDs also have gastrointestinal side effects. The review describes the effect of NSAID, on orthodontic tooth movement.
In text/plain format

Archived Files and Locations