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Maternal Vaccination With a Monocomponent Pertussis Toxoid Vaccine Is Sufficient to Protect Infants in a Baboon Model of Whooping Cough
release_vqnt64t7wfbp3fgtnurwi4qjue
by
Parul Kapil,
James F Papin,
Roman F Wolf,
Lindsey I Zimmerman,
Leslie D Wagner,
Tod J Merkel
Published
in Journal of Infectious Diseases
by Oxford University Press (OUP).
2018 Volume 217, Issue 8, p1231-1236
Abstract
Bordetella pertussis is a human pathogen responsible for serious respiratory illness. The disease is most severe in infants too young to be vaccinated with most hospitalizations and deaths occurring within this age group. The Advisory Committee on Immunization Practices recommended immunization of pregnant women to protect infants from birth until their first vaccination at 6-8 weeks of age. We previously demonstrated that maternal vaccination with licensed acellular pertussis vaccines protected newborn baboons from disease. We hypothesized that protection was due to toxin-neutralizing, maternal anti-pertussis toxin antibodies and predicted that maternal vaccination with a pertussis toxoid (PTx)-only vaccine would protect newborns from disease.
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