Fatcat About Guide Changelog IA Scholar

An immune-related model based on INHBA, JAG2 and CCL19 to predict the prognoses of colon cancer patients release_uc55udy4xfctngvxypkiwvz5eu

by Xuankun Yang, Jia Yan, Yahui Jiang, Yaxu Wang

Entity Metadata (schema)

abstracts[] {'sha1': 'da08b9785ef9fa93c5629614992ba7d22328c544', 'content': '<jats:title>Abstract</jats:title><jats:sec>\n <jats:title>Background</jats:title>\n Colorectal cancer (CRC) is the leading cause of cancer deaths and most common malignant tumors worldwide. Immune-related genes (IRGs) can predict prognoses of patients and the effects of immunotherapy. A series of colon cancer (CCa) samples from The Cancer Genome Atlas (TCGA) were analyzed to provide a new perspective into this field.\n </jats:sec><jats:sec>\n <jats:title>Methods</jats:title>\n Differential IRGs and IRGs with significant clinical outcomes (sIRGs) were calculated by the limma algorithm and univariate COX regression analysis. The potential molecular mechanisms of IRGs were detected by PPI, KEGG and GO analysis. Immune-related risk score model (IRRSM) was established based on multivariate COX regression analysis. Based on the median risk score of IRRSM, the high-risk group and low-risk group were distinguished. The expression levels of IHNBA and JAG2 and relationships between IHNBA and clinical features were verified by RT-qPCR.\n </jats:sec><jats:sec>\n <jats:title>Results</jats:title>\n 6 differential sIRGs of patients with CCa were selected by univariate COX regression analysis. Based on the sIRGs (INHBA, JAG2 and CCL19), the IRRSM was established to predict survival probability of CCa patients and to explore the potential correlations with clinical features. Furthermore, IRRSM reflected the infiltration status of 22 types of immune cells. The expression levels of IHNBA and JAG2 were higher in CCa tissues than that in adjacent normal tissues. The expression levels of IHNBA and JAG2 were increased in advanced T stages.\n </jats:sec><jats:sec>\n <jats:title>Conclusion</jats:title>\n Our results illustrated that some sIRGs showed the latent value of predicting the prognoses of CCa patients and the clinical features. This study could provide a new insight for immune research and treatment strategies in CCa patients.\n </jats:sec>', 'mimetype': 'application/xml+jats', 'lang': None}
container {'state': 'active', 'ident': '24iikjdiwfezletlvdfiwv5xyy', 'revision': 'c3673dbe-6aa5-4076-9196-18e0cc1262c2', 'redirect': None, 'extra': {'abbrev': 'Cancer Cell Int.', 'country': 'gb', 'default_license': 'CC-BY', 'doaj': {'archive': ['CLOCKSS', 'LOCKSS', 'PMC', 'Portico'], 'as_of': '2022-07-06', 'default_license': 'CC-BY, CC0', 'seal': True}, 'kbart': {'clockss': {'year_spans': [[2001, 2022]]}, 'lockss': {'year_spans': [[2001, 2018]]}, 'portico': {'year_spans': [[2001, 2022]]}}, 'languages': ['en'], 'platform': 'bmc', 'publisher_type': 'big5', 'road': {'as_of': '2018-01-24'}, 'sherpa_romeo': {'color': 'green'}, 'urls': ['http://www.biomedcentral.com/1475-2867', 'http://www.cancerci.com/', 'http://www.cancerci.com/info/about/']}, 'edit_extra': None, 'name': 'Cancer Cell International', 'container_type': None, 'publication_status': None, 'publisher': 'Springer (Biomed Central Ltd.)', 'issnl': '1475-2867', 'issne': '1475-2867', 'issnp': '1475-2867', 'wikidata_qid': 'Q1829859'}
container_id 24iikjdiwfezletlvdfiwv5xyy
contribs[] {'index': 0, 'creator_id': None, 'creator': None, 'raw_name': 'Xuankun Yang', 'given_name': 'Xuankun', 'surname': 'Yang', 'role': 'author', 'raw_affiliation': None, 'extra': {'seq': 'first'}}
{'index': 1, 'creator_id': None, 'creator': None, 'raw_name': 'Jia Yan', 'given_name': 'Jia', 'surname': 'Yan', 'role': 'author', 'raw_affiliation': None, 'extra': None}
{'index': 2, 'creator_id': None, 'creator': None, 'raw_name': 'Yahui Jiang', 'given_name': 'Yahui', 'surname': 'Jiang', 'role': 'author', 'raw_affiliation': None, 'extra': None}
{'index': 3, 'creator_id': None, 'creator': None, 'raw_name': 'Yaxu Wang', 'given_name': 'Yaxu', 'surname': 'Wang', 'role': 'author', 'raw_affiliation': None, 'extra': None}
ext_ids {'doi': '10.1186/s12935-021-02000-z', 'wikidata_qid': None, 'isbn13': None, 'pmid': '34103052', 'pmcid': None, 'core': None, 'arxiv': None, 'jstor': None, 'ark': None, 'mag': None, 'doaj': None, 'dblp': None, 'oai': None, 'hdl': None}
files[] {'state': 'active', 'ident': '7trpnbievvayngqdc7f3pn2ojm', 'revision': 'de417d8c-f010-47d6-b823-1ef754224834', 'redirect': None, 'extra': None, 'edit_extra': None, 'size': 4688031, 'md5': '9da146c0e901caf3c5bd1ef64aba9586', 'sha1': 'f54327c04eeec58494c85005021bc68c6e1c1d35', 'sha256': '7edcf1729de01905e89ab6f8dfec68dc755bcae0bcada9f573bca31b2de46570', 'urls': [{'url': 'https://cancerci.biomedcentral.com/track/pdf/10.1186/s12935-021-02000-z.pdf', 'rel': 'publisher'}, {'url': 'https://web.archive.org/web/20210617065258/https://cancerci.biomedcentral.com/track/pdf/10.1186/s12935-021-02000-z.pdf', 'rel': 'webarchive'}], 'mimetype': 'application/pdf', 'content_scope': None, 'release_ids': ['uc55udy4xfctngvxypkiwvz5eu'], 'releases': None}
filesets []
issue 1
language en
license_slug CC-BY
number
original_title
pages 299
publisher Springer Science and Business Media LLC
refs[] {'index': 0, 'target_release_id': None, 'extra': {'authors': ['N Keum'], 'doi': '10.1038/s41575-019-0189-8', 'unstructured': 'Keum N, Giovannucci E. Global burden of colorectal cancer: emerging trends, risk factors and prevention strategies. Nat Rev Gastroenterol Hepatol. 2019;16:713–32. https://doi.org/10.1038/s41575-019-0189-8.', 'volume': '16'}, 'key': '2000_CR1', 'year': 2019, 'container_name': 'Nat Rev Gastroenterol Hepatol', 'title': None, 'locator': '713'}
{'index': 1, 'target_release_id': None, 'extra': {'authors': ['F Bray'], 'doi': '10.3322/caac.21492', 'unstructured': 'Bray F, et al. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018;68:394–424. https://doi.org/10.3322/caac.21492.', 'volume': '68'}, 'key': '2000_CR2', 'year': 2018, 'container_name': 'CA Cancer J Clin', 'title': None, 'locator': '394'}
{'index': 2, 'target_release_id': None, 'extra': {'authors': ['R Huang'], 'doi': '10.18632/aging.103054', 'unstructured': 'Huang R, Mao M, Lu Y, Yu Q, Liao L. A novel immune-related genes prognosis biomarker for melanoma: associated with tumor microenvironment. Aging. 2020;12:6966–80. https://doi.org/10.18632/aging.103054.', 'volume': '12'}, 'key': '2000_CR3', 'year': 2020, 'container_name': 'Aging', 'title': None, 'locator': '6966'}
{'index': 3, 'target_release_id': None, 'extra': {'authors': ['D Elias'], 'doi': '10.1200/jco.2009.23.9285', 'unstructured': 'Elias D, et al. Peritoneal colorectal carcinomatosis treated with surgery and perioperative intraperitoneal chemotherapy: retrospective analysis of 523 patients from a multicentric French study. J Clin Oncol. 2010;28:63–8. https://doi.org/10.1200/jco.2009.23.9285.', 'volume': '28'}, 'key': '2000_CR4', 'year': 2010, 'container_name': 'J Clin Oncol', 'title': None, 'locator': '63'}
{'index': 4, 'target_release_id': None, 'extra': {'authors': ['K Ganesh'], 'doi': '10.1038/s41575-019-0126-x', 'unstructured': 'Ganesh K, et al. Immunotherapy in colorectal cancer: rationale, challenges and potential. Gastroenterol Hepatol. 2019;16:361–75. https://doi.org/10.1038/s41575-019-0126-x.', 'volume': '16'}, 'key': '2000_CR5', 'year': 2019, 'container_name': 'Gastroenterol Hepatol', 'title': None, 'locator': '361'}
{'index': 5, 'target_release_id': None, 'extra': {'authors': ['M Koi'], 'doi': '10.2217/fon-2017-0145', 'unstructured': 'Koi M, Carethers JM. The colorectal cancer immune microenvironment and approach to immunotherapies. Future Oncol. 2017;13:1633–47. https://doi.org/10.2217/fon-2017-0145.', 'volume': '13'}, 'key': '2000_CR6', 'year': 2017, 'container_name': 'Future Oncol', 'title': None, 'locator': '1633'}
{'index': 6, 'target_release_id': None, 'extra': {'authors': ['J Galon'], 'doi': '10.1038/s41573-018-0007-y', 'unstructured': 'Galon J, Bruni D. Approaches to treat immune hot, altered and cold tumours with combination immunotherapies. Nat Rev Drug Discov. 2019;18:197–218. https://doi.org/10.1038/s41573-018-0007-y.', 'volume': '18'}, 'key': '2000_CR7', 'year': 2019, 'container_name': 'Nat Rev Drug Discov', 'title': None, 'locator': '197'}
{'index': 7, 'target_release_id': None, 'extra': {'authors': ['D Ciardiello'], 'doi': '10.1016/j.ctrv.2019.04.003', 'unstructured': 'Ciardiello D, et al. Immunotherapy of colorectal cancer: challenges for therapeutic efficacy. Cancer Treat Rev. 2019;76:22–32. https://doi.org/10.1016/j.ctrv.2019.04.003.', 'volume': '76'}, 'key': '2000_CR8', 'year': 2019, 'container_name': 'Cancer Treat Rev', 'title': None, 'locator': '22'}
{'index': 8, 'target_release_id': None, 'extra': {'authors': ['N Yaghoubi'], 'doi': '10.1016/j.biopha.2018.11.105', 'unstructured': 'Yaghoubi N, Soltani A, Ghazvini K, Hassanian SM, Hashemy SI. PD-1/ PD-L1 blockade as a novel treatment for colorectal cancer. Biomed Pharmacother. 2019;110:312–8. https://doi.org/10.1016/j.biopha.2018.11.105.', 'volume': '110'}, 'key': '2000_CR9', 'year': 2019, 'container_name': 'Biomed Pharmacother', 'title': None, 'locator': '312'}
{'index': 9, 'target_release_id': None, 'extra': {'authors': ['A Barsouk'], 'doi': '10.3390/medsci8030028', 'unstructured': 'Barsouk A, et al. Epidemiology, staging and management of prostate cancer. Med Sci. 2020. https://doi.org/10.3390/medsci8030028.'}, 'key': '2000_CR10', 'year': 2020, 'container_name': 'Med Sci', 'title': None, 'locator': None}
{'index': 10, 'target_release_id': None, 'extra': {'authors': ['H Zhuang'], 'doi': '10.1007/s12094-020-02365-z', 'unstructured': 'Zhuang H, Zhang C, Hou B. FAM83H overexpression predicts worse prognosis and correlates with less CD8 T cells infiltration and Ras-PI3K-Akt-mTOR signaling pathway in pancreatic cancer. Clin Transl Oncol. 2020. https://doi.org/10.1007/s12094-020-02365-z.'}, 'key': '2000_CR11', 'year': 2020, 'container_name': 'Clin Transl Oncol', 'title': None, 'locator': None}
{'index': 11, 'target_release_id': None, 'extra': {'authors': ['T Wu'], 'doi': '10.1016/j.canlet.2016.01.043', 'unstructured': 'Wu T, Dai Y. Tumor microenvironment and therapeutic response. Cancer Lett. 2017;387:61–8. https://doi.org/10.1016/j.canlet.2016.01.043.', 'volume': '387'}, 'key': '2000_CR12', 'year': 2017, 'container_name': 'Cancer Lett', 'title': None, 'locator': '61'}
{'index': 12, 'target_release_id': None, 'extra': {'authors': ['L Hui'], 'doi': '10.1016/j.canlet.2015.07.039', 'unstructured': 'Hui L, Chen Y. Tumor microenvironment: Sanctuary of the devil. Cancer Lett. 2015. https://doi.org/10.1016/j.canlet.2015.07.039.'}, 'key': '2000_CR13', 'year': 2015, 'container_name': 'Cancer Lett', 'title': None, 'locator': None}
{'index': 13, 'target_release_id': None, 'extra': {'authors': ['S Gnjatic'], 'doi': '10.1186/s40425-017-0243-4', 'unstructured': 'Gnjatic S, et al. Identifying baseline immune-related biomarkers to predict clinical outcome of immunotherapy. J Immunother Cancer. 2017;5:44. https://doi.org/10.1186/s40425-017-0243-4.'}, 'key': '2000_CR14', 'year': 2017, 'container_name': 'J Immunother Cancer', 'title': None, 'locator': '44'}
{'index': 14, 'target_release_id': None, 'extra': {'authors': ['X Shi'], 'doi': '10.1186/s12967-020-02233-y', 'unstructured': 'Shi X, et al. IRGS: an immune-related gene classifier for lung adenocarcinoma prognosis. J Transl Med. 2020;18:55. https://doi.org/10.1186/s12967-020-02233-y.', 'volume': '18'}, 'key': '2000_CR15', 'year': 2020, 'container_name': 'J Transl Med', 'title': None, 'locator': '55'}
{'index': 15, 'target_release_id': None, 'extra': {'authors': ['H Locy'], 'doi': '10.3389/fimmu.2018.02909', 'unstructured': 'Locy H, et al. Immunomodulation of the tumor microenvironment: Turn foe into friend. Front Immunol. 2018;9:2909. https://doi.org/10.3389/fimmu.2018.02909.'}, 'key': '2000_CR16', 'year': 2018, 'container_name': 'Front Immunol', 'title': None, 'locator': '2909'}
{'index': 16, 'target_release_id': None, 'extra': {'authors': ['P Darvin'], 'doi': '10.1038/s12276-018-0191-1', 'unstructured': 'Darvin P, Toor SM, Sasidharan Nair V, Elkord E. Immune checkpoint inhibitors: recent progress and potential biomarkers. Exp Mol Med. 2018. https://doi.org/10.1038/s12276-018-0191-1.'}, 'key': '2000_CR17', 'year': 2018, 'container_name': 'Exp Mol Med', 'title': None, 'locator': None}
{'index': 17, 'target_release_id': None, 'extra': {'authors': ['L Corrales'], 'doi': '10.1038/cr.2016.149', 'unstructured': 'Corrales L, Matson V, Flood B, Spranger S, Gajewski TF. Innate immune signaling and regulation in cancer immunotherapy. Cell Res. 2017. https://doi.org/10.1038/cr.2016.149.'}, 'key': '2000_CR18', 'year': 2017, 'container_name': 'Cell Res', 'title': None, 'locator': None}
{'index': 18, 'target_release_id': None, 'extra': {'authors': ['JN Kather'], 'doi': '10.1016/j.semcancer.2018.02.010', 'unstructured': 'Kather JN, Halama N, Jaeger D. Genomics and emerging biomarkers for immunotherapy of colorectal cancer. Semin Cancer Biol. 2018;52:189–97. https://doi.org/10.1016/j.semcancer.2018.02.010.', 'volume': '52'}, 'key': '2000_CR19', 'year': 2018, 'container_name': 'Semin Cancer Biol', 'title': None, 'locator': '189'}
{'index': 19, 'target_release_id': None, 'extra': {'authors': ['J Tintelnot'], 'doi': '10.3748/wjg.v25.i29.3920', 'unstructured': 'Tintelnot J, Stein A. Immunotherapy in colorectal cancer: available clinical evidence, challenges and novel approaches. World J Gastroenterol. 2019;25:3920–8. https://doi.org/10.3748/wjg.v25.i29.3920.', 'volume': '25'}, 'key': '2000_CR20', 'year': 2019, 'container_name': 'World J Gastroenterol', 'title': None, 'locator': '3920'}
{'index': 20, 'target_release_id': None, 'extra': {'authors': ['K Ganesh'], 'doi': '10.1038/s41575-019-0126-x', 'unstructured': 'Ganesh K, et al. Immunotherapy in colorectal cancer: rationale, challenges and potential. Nat Rev Gastroenterol Hepatol. 2019;16:361–75. https://doi.org/10.1038/s41575-019-0126-x.', 'volume': '16'}, 'key': '2000_CR21', 'year': 2019, 'container_name': 'Nat Rev Gastroenterol Hepatol', 'title': None, 'locator': '361'}
{'index': 21, 'target_release_id': None, 'extra': {'authors': ['F Petitprez'], 'doi': '10.1007/s00262-017-2058-z', 'unstructured': 'Petitprez F, et al. Transcriptomic analysis of the tumor microenvironment to guide prognosis and immunotherapies. Cancer Immunol Immunother. 2018;67:981–8. https://doi.org/10.1007/s00262-017-2058-z.', 'volume': '67'}, 'key': '2000_CR22', 'year': 2018, 'container_name': 'Cancer Immunol Immunother', 'title': None, 'locator': '981'}
{'index': 22, 'target_release_id': None, 'extra': {'authors': ['SD Soysal'], 'doi': '10.1159/000430499', 'unstructured': 'Soysal SD, Tzankov A, Muenst SE. Role of the tumor microenvironment in breast cancer. Pathobiology. 2015;82:142–52. https://doi.org/10.1159/000430499.', 'volume': '82'}, 'key': '2000_CR23', 'year': 2015, 'container_name': 'Pathobiology', 'title': None, 'locator': '142'}
{'index': 23, 'target_release_id': None, 'extra': {'authors': ['D Bruni'], 'doi': '10.1038/s41568-020-0285-7', 'unstructured': 'Bruni D, Angell H, Galon J. The immune contexture and Immunoscore in cancer prognosis and therapeutic efficacy. Nat Rev Cancer. 2020. https://doi.org/10.1038/s41568-020-0285-7.'}, 'key': '2000_CR24', 'year': 2020, 'container_name': 'Nat Rev Cancer', 'title': None, 'locator': None}
{'index': 24, 'target_release_id': None, 'extra': {'authors': ['J Galon'], 'doi': '10.1016/j.immuni.2019.12.018', 'unstructured': 'Galon J, Bruni DJI. Tumor immunology and tumor evolution: intertwined histories. Immunity. 2020;52:55–81. https://doi.org/10.1016/j.immuni.2019.12.018.', 'volume': '52'}, 'key': '2000_CR25', 'year': 2020, 'container_name': 'Immunity', 'title': None, 'locator': '55'}
{'index': 25, 'target_release_id': None, 'extra': {'authors': ['GT Gibney'], 'doi': '10.1016/s1470-2045(16)30406-5', 'unstructured': 'Gibney GT, Weiner LM, Atkins MB. Predictive biomarkers for checkpoint inhibitor-based immunotherapy. Lancet Oncol. 2016;17:e542–51. https://doi.org/10.1016/S1470-2045(16)30406-5.', 'volume': '17'}, 'key': '2000_CR26', 'year': 2016, 'container_name': 'Lancet Oncol', 'title': None, 'locator': 'e542'}
{'index': 26, 'target_release_id': None, 'extra': {'authors': ['B Jiang'], 'doi': '10.1097/md.0000000000016273', 'unstructured': 'Jiang B, et al. An immune-related gene signature predicts prognosis of gastric cancer. Medicine (Baltimore). 2019;98:e16273. https://doi.org/10.1097/MD.0000000000016273.', 'volume': '98'}, 'key': '2000_CR27', 'year': 2019, 'container_name': 'Medicine (Baltimore)', 'title': None, 'locator': 'e16273'}
{'index': 27, 'target_release_id': None, 'extra': {'authors': ['Y She'], 'doi': '10.1186/s12935-020-1104-7', 'unstructured': 'She Y, et al. Immune-related gene signature for predicting the prognosis of head and neck squamous cell carcinoma. Cancer Cell Int. 2020;20:22. https://doi.org/10.1186/s12935-020-1104-7.', 'volume': '20'}, 'key': '2000_CR28', 'year': 2020, 'container_name': 'Cancer Cell Int', 'title': None, 'locator': '22'}
{'index': 28, 'target_release_id': None, 'extra': {'authors': ['VL Chiou'], 'doi': '10.1200/jco.2015.61.6870', 'unstructured': 'Chiou VL, Burotto M. Pseudoprogression and immune-related response in solid tumors. J Clin Oncol. 2015;33:3541–3. https://doi.org/10.1200/JCO.2015.61.6870.', 'volume': '33'}, 'key': '2000_CR29', 'year': 2015, 'container_name': 'J Clin Oncol', 'title': None, 'locator': '3541'}
{'index': 29, 'target_release_id': None, 'extra': {'authors': ['Y Mao'], 'doi': '10.2147/cmar.s171855', 'unstructured': 'Mao Y, et al. Low tumor purity is associated with poor prognosis, heavy mutation burden, and intense immune phenotype in colon cancer. Cancer Manag Res. 2018;10:3569–77. https://doi.org/10.2147/CMAR.S171855.', 'volume': '10'}, 'key': '2000_CR30', 'year': 2018, 'container_name': 'Cancer Manag Res', 'title': None, 'locator': '3569'}
{'index': 30, 'target_release_id': None, 'extra': {'authors': ['C Zhang'], 'doi': '10.1158/1078-0432.ccr-16-2598', 'unstructured': 'Zhang C, et al. Tumor purity as an underlying key factor in glioma. Clin Cancer Res. 2017;23:6279–91. https://doi.org/10.1158/1078-0432.CCR-16-2598.', 'volume': '23'}, 'key': '2000_CR31', 'year': 2017, 'container_name': 'Clin Cancer Res', 'title': None, 'locator': '6279'}
release_date 2021-06-08
release_stage published
release_type article-journal
release_year 2021
subtitle
title An immune-related model based on INHBA, JAG2 and CCL19 to predict the prognoses of colon cancer patients
version
volume 21
webcaptures []
withdrawn_date
withdrawn_status
withdrawn_year
work_id ujje3pxqhrhulomyo42e27zriu
As JSON via API

Extra Metadata (raw JSON)

crossref.alternative-id ['2000']
crossref.license [{'URL': 'https://creativecommons.org/licenses/by/4.0', 'content-version': 'vor', 'delay-in-days': 0, 'start': '2021-06-08T00:00:00Z'}]
crossref.subject ['Genetics', 'Cancer Research', 'Oncology']
crossref.type journal-article
pubmed.pub_types ['Journal Article']