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Hyperhomocysteinemia and its correction in posttrombotic syndrome of the lower limbs
release_t7q6oo7qk5h37mhkxhulhy5auy
by
R E Kalinin,
I A Suchkov,
I N Rudakova,
L V Nikiforova
Published
in RUDN Journal of Medicine
by Peoples' Friendship University of Russia (RUDN University).
2016 p61-67
Abstract
The article is about hyperhomocysteinemia which retards recanalization processes after deep vein thrombosis and leads to the lower extremities post-thrombotic syndrome. Levels of blood homocysteine were determined at admission, after 1 and 3 months after the acute thrombosis of the deep veins of the lower extremities. Increased levels of homocysteine were revealed. Maximum concentration of homocysteine was 31.6 mmol/l, which corresponds to moderate hyperhomocysteinemia. In patients receiving anticoagulants for 3 months the level of homocysteine slightly decreased. Prescription of vitamins B6, B9, B12 allows significantly decrease the homocysteine levels, improve health outcomes, reduce the number of patients with class C3-4.
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