Plasma fibrinogen levels and all-cause and cause-specific mortality in an Italian adult population: results from the Moli-sani study release_s5v4ufxztvhtrmewenxrwzp56q

by Roberta Parisi, Simona Costanzo, Romy De Laat-Kremers, Augusto Di Castelnuovo, amalia de curtis, Teresa Panzera, Mariarosaria Persichillo, Chiara Cerletti, Giovanni de Gaetano, Maria Benedetta Donati, Licia Iacoviello, Bas De Laat (+1 others)

Published in Bleeding Thrombosis and Vascular Biology by PAGEPress Publications.

2023  

Abstract

Epidemiological data on the association between fibrinogen levels and mortality are scarse and controversial. Longitudinal analyses were performed, separately by sex, on 17,689 individuals from the Moli-sani study [53% women, ≥35 years, free from cardiovascular disease (CVD) or cancer at enrolment], to evaluate the association between plasma fibrinogen and all-cause and cause-specific mortality. Over a median follow-up of 11.2 years, 1,058 deaths (34.7% CVD, 36.3% cancer) were ascertained. Both in the lowest (1.12-2.64 g/L) and highest (≥3.62 g/L) fibrinogen quintiles, women had an increased all-cause mortality hazard, when compared with third quintile (2.97-3.23 g/L). Dose-response analyses showed a U-shaped relationship in women (P overall <0.0001; P non-linear association <0.0001), but a positive linear association for all-cause mortality in men (P overall 0.0038; P non-linear association 0.76). Similar trends for a U-shaped association were observed for CVD mortality, while no association was observed with cancer deaths. A U-shaped association of fibrinogen levels with other-cause mortality was also found in both sexes. This study shows that not only higher but also lower fibrinogen levels represent hazard for mortality when compared to normal levels; U-shaped curves being prevalently observed in women.
In application/xml+jats format

Archived Files and Locations

application/pdf   2.1 MB
file_2kbse73fs5dstfe332fnwppapm
btvb.org (publisher)
web.archive.org (webarchive)
Read Archived PDF
Preserved and Accessible
Type  article-journal
Stage   published
Date   2023-01-27
Container Metadata
Not in DOAJ
Not in Keepers Registry
ISSN-L:  2785-5309
Work Entity
access all versions, variants, and formats of this works (eg, pre-prints)
Catalog Record
Revision: e6c4ded8-c1bb-496f-8130-a51a6c941b45
API URL: JSON