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The Blood Lactate/Pyruvate Equilibrium Affair
release_ryy256ajkfdnvkrqtsl3hnqtam
by
George A. Brooks,
Adam Osmond,
Robert G Leija,
Casey C Curl,
Jose A Arevalo,
Justin Duong,
Michael A. Horning
Published
in American Journal of Physiology. Endocrinology and Metabolism
by American Physiological Society.
2021 Volume 322, Issue 1, E34-E43
Abstract
The Lactate Shuttle hypothesis is supported by a variety of techniques including mass spectrometry analytics following infusion of carbon labeled isotopic tracers. However, there has been controversy over whether lactate tracers measure lactate (L) or pyruvate (P) turnover. Here we review the analytical errors, use of inappropriate tissue and animal models, failure to consider L and P pool sizes in modeling results, inappropriate tracer and blood sampling sites, and failure to anticipate roles of heart and lung parenchyma on L:P interactions. With support from magnetic resonance spectroscopy (MRS) and immunocytochemistry we conclude that carbon-labeled lactate tracers can be used to quantitate lactate fluxes.
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Crossref Metadata (via API)
Worldcat
SHERPA/RoMEO (journal policies)
wikidata.org
CORE.ac.uk
Semantic Scholar
Google Scholar