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Therapeutic Potential of Melatonin in the Regulation of MiR-148a-3p and Angiogenic Factors in Breast Cancer
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by
Jéssica Zani Lacerda,
Lívia Carvalho Ferreira,
Beatriz Camargo Lopes,
Andrés Felipe Aristizábal-Pachón,
Marcio Chaim Bajgelman,
Thaiz Ferraz Borin,
Debora Aparecida Pires de Campos Zuccari
Abstract
The high mortality rate of breast cancer is related to the occurrence of metastasis, a process that is promoted by tumor angiogenesis. MicroRNAs are small molecules of noncoding mRNA that play a key role in gene regulation and are directly involved in the progression and angiogenesis of various tumor types, including breast cancer. Several miRNAs have been described as promoters or suppressors angiogenesis and may be associated with tumor growth and metastasis. Melatonin is an oncostatic agent with a capacity of modifying the expression of innumerable genes and miRNAs related to cancer.
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