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Unveiling the intricacy of gapmer oligonucleotides through advanced tandem mass spectrometry approaches and scan accumulation for 2DMS
release_rev_6a42280a-4dd5-43fb-8d83-a305f33341cb
by
Mohammed Rahman,
Bryan P. Marzullo,
Pui Yiu Lam,
Mark Barrow,
Stephen William Holman,
Andrew Ray,
Peter O'Connor
Abstract
Antisense oligonucleotides (ASOs) are crucial for biological applications as they bind to complementary RNA sequences, modulating protein expression. ASOs undergo synthetic modifications like phosphorothioate (PS) backbone and locked nucleic acid...
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