Fecal microbiota transplantation via colonoscopy in a dog with Clostridioides (Clostridium) difficile infection release_rev_03793983-b592-41a9-9a45-b32531e39809

by Amanda Nadia Diniz, Angélica da Costa Ferreira de Souza, Anelise Carvalho Nepomuceno, Sóstenes Apolo Correia Marcelino, Felipe Pierezan, Francisco Carlos Faria Lobato, Rodrigo Otávio Silveira Silva

Published in Ciência Rural by FapUNIFESP (SciELO).

2021   Volume 51

Abstract

ABSTRACT: In dogs, antimicrobial therapy for Clostridioides (Clostridium) difficile infection (CDI) is based solely on metronidazole, leaving limited treatment options in case of recurrent disease. Fecal microbiota transplantation (FMT) has been successfully used in humans with recurrent CDI, whereas the usefulness of this approach is largely unknown in dogs. In the present study, a dog with a chronic-recurring diarrhea was treated with FMT via colonoscopy. CDI was confirmed by A/B toxin detection and isolation of toxigenic C. difficile from ribotype 106, a strain also commonly associated with nosocomial infection in humans. The dog recovered well after the procedure and C. difficile was no longer isolated from its stool sample. The present research suggested that FMT could be a useful tool to treat recurrent CDI in dogs, corroborating the actual protocol in humans.
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