ASSOCIATION OF-129C/T PROMOTER GCLC POLYMORPHISM WITH GLUTATHIONE PLASMA LEVEL IN PULMONARY TUBERCULOSIS PATIENTS release_re2sabtv45cmhmx5c4ywfrdipq

Abstract

Genetic polymorphism of glutamate-cysteine ligase (GCL) could lead the changes in GCL enzyme activities. These changes could disrupt glutathione synthesis allowing the reduction of glutathione level. Furthermore, the decrease of glutathione level would change the phenotype and lead to the lack of defense against some diseases. The aim of this study was to determine the relationship between genetic polymorphism of the-129C/T promoter region in glutamate-cysteine ligase sub unit catalytic (GCLC) genes with glutathione plasma level in pulmonary tuberculosis patients. A prospective cohort study was conducted to study this association. The samples were obtained from the center of health lung community (BBKPM) and Labuang Baji Hospital, Makassar, Indonesia in accordance with the inclusion and exclusion criteria. The consecutive sampling technique was accomplished based on the order of arrival of the patient. Analysis of genetic polymorphism and glutathione level in pulmonary tuberculosis patients were performed. The results of study indicated that genetic polymorphism of C/C was increased by 11% in genotype C/C whereas in genotype C/T was decreased by 32%. According to the results, the polymorphisms of GCLC gene were associated with glutathione level in pulmonary tuberculosis patients.
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