METAL-CHELATOR THERAPY : STABILITY CONSTANTS OF TRANSITION METAL COMPLEXES OF PYRIMIDINE AND SULPHONAMIDE DRUGS release_r2qbfngap5f65cczmrjm34rcu4

Abstract

Stability constant of metal complexes of pyrimidine and sulphonamides drugs were determined using spectrophotometric method. Stability constants of the complexes were determined at 25 o C. Ionic strength was maintained constant using 0.1M KNO 3. . Stoichometry of the complexes by Job ' s method showed that metal-drug ratio is 1 : 2. For the metal salts, the order of stability constant (β) was found to be Cu (II) > Fe (III) > Ni (II) > Co (II) > Zn (II) in accordance with lrving-Williams series. The overall stability constants (β) were found to be log 10.68, 5.5 and 4.8 for trimethoprim, sulphadiazine and sulphadimidine, respectively. The order of stability constant follows this trend: Trimethoprim > Sulphadiazine > Sulphadimidine. The stability constant data revealed that this ligand may be used as antidote or chelating agent for medical treatment of metals overload or poisoning.
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