Cyclin D1 expression in penile cancer
release_qt3q6neaynh3rcuxwx2nlz36fa
by
Wesliany Everton Duarte,
Jaqueline Diniz Pinho,
Syomara Pereira da Costa Melo,
Denner Rodrigo Diniz Duarte,
Juliana Martins da Guia Ribeiro do Carmo,
André Salim Khayat,
José Ribamar Rodrigues Calixto,
Marcos Adriano Garcia Campos,
Rita da Graça Carvalhal Frazão Correa,
Antonio Machado Alencar Júnior,
Antônio Augusto Lima Teixeira-Júnior,
Gyl Eanes Barros Silva
Abstract
The main goal of the present study was to analyze the expression profile of cyclin D1 in patients with PC, and to determine possible correlations with clinical and histopathological features. A survey was conducted with 100 patients diagnosed with PC, who were treated at two reference hospitals in São Luís, Maranhão, Brazil, between 2013 and 2017. A review of clinical, epidemiological, and histopathological data was performed, Human Papillomavírus (HPV) DNA was detected using polymerase chain reaction (PCR) and cyclin D1 expression analysis was performed using immunohistochemical techniques. The data revealed that the absence of cyclin D1 expression was significantly associated with HPV-positive histological subtypes (p = 0.001), while its expression was associated with high-grade tumors (p = 0.014), histological subtype (p = 0.001), presence of sarcomatoid transformation (p = 0.04), and perineural invasion (p = 0.023). Patients with cyclin D1 expression exhibited lower disease-free survival compared to the cyclin D1-negative group, although the difference was not statistically significant. The results suggest that cyclin D1 may be a potential biomarker for PC, especially for poorer prognosis.
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1949-2553
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