Transient Mutism Related to Capecitabine-Induced Acute Toxic Leukoencephalopathy release_qjs3g3oj2fecrmpqlstmfdrrmu

by Hyung Ho Kim, Hyunji Kim, Sumin Kim, Soo-Hyun Kim, Geon Ha Kim

Published in Journal of the Korean Neurological Association by Korean Neurological Association.

2022   Volume 40, p172-175

Abstract

Capecitabine, a precursor of 5-fluorouracil (5-FU), is a well-tolerated and safe chemotherapy that has been used to treat breast, pancreatic, and colorectal cancers. Albeit rare, both 5-FU and capecitbine have been reported to be associated with acute central nervous system toxicity, including cerebellar dysfunction, posterior reversible encephalopathy syndrome, and transient leukoencephalopathies. Here we present a case of 32-year-old female, demonstrating transient mutism related to capecitabine induced acute toxic leukoencephalopathy.
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