Unveiling the intricacy of gapmer oligonucleotides through advanced tandem mass spectrometry approaches and scan accumulation for 2DMS release_pikbiauv3fbrzbcgjkm4ssn63u

by Mohammed Rahman, Bryan P. Marzullo, Pui Yiu Lam, Mark Barrow, Stephen William Holman, Andrew Ray, Peter O'Connor

Published in The Analyst by Royal Society of Chemistry (RSC).

2024  

Abstract

Antisense oligonucleotides (ASOs) are crucial for biological applications as they bind to complementary RNA sequences, modulating protein expression. ASOs undergo synthetic modifications like phosphorothioate (PS) backbone and locked nucleic acid...
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Type  article-journal
Stage   published
Date   2024-08-05
Language   en ?
DOI  10.1039/d4an00484a
PubMed  39101388
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ISSN-L:  0003-2654
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