Etiologies and treatments of chronic intestinal failure-short bowel syndrome (SBS) in Japanese adults: a real-world observational study
release_pei24utlrnb4hkbhmypx3tneru
by
Tsunekazu Mizushima,
Eri Udagawa,
Miyuki Hasegawa,
Yuko Tazuke,
Hiroomi Okuyama,
Jovelle Fernandez,
Shiro Nakamura
2022 Volume 52, Issue 9, p1350-1357
Abstract
<jats:title>Abstract</jats:title><jats:sec>
<jats:title>Purpose</jats:title>
Short bowel syndrome (SBS) with intestinal failure (SBS-IF) requires long-term parenteral nutrition (PN). This study investigated the real-world etiologies of SBS, treatment patterns, and PN-related outcomes among adult patients with SBS-IF in Japan.
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<jats:title>Methods</jats:title>
This retrospective, observational cohort study was based on data from April, 2008 to January, 2020 from one of the largest hospital-based claim databases in Japan. Analyzed patients were aged ≥ 16 years, had received continuous PN for ≥ 6 months, and had SBS or undergone SBS-related surgery with a diagnosis of a causative disease. The primary endpoint was PN weaning.
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<jats:title>Results</jats:title>
We analyzed data for 393 patients. The most frequent causes of SBS-IF were ileus (31.8%), Crohn's disease (20.1%), and mesenteric ischemia (16.0%). Of 144/393 (36.6%) patients who were weaned off their PN, 48 (33.3%) were subsequently restarted on PN. Of 276/393 (70.2%) patients whose PN was initiated in hospital, 156 (56.5%) transitioned to home management. The mean duration of initial PN was 450.4 and 675.5 days for patients who were able or unable to be weaned off PN, respectively. Sepsis (67.4%), catheter-related bloodstream infections (49.1%), and liver disorders (45.0%) were the most reported PN-related complications.
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<jats:title>Conclusions</jats:title>
Most patients with SBS-IF in Japan could not be weaned off PN and suffered life-threatening complications.
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