Etiologies and treatments of chronic intestinal failure-short bowel syndrome (SBS) in Japanese adults: a real-world observational study release_pei24utlrnb4hkbhmypx3tneru

by Tsunekazu Mizushima, Eri Udagawa, Miyuki Hasegawa, Yuko Tazuke, Hiroomi Okuyama, Jovelle Fernandez, Shiro Nakamura

Published in Surgery today (Print) by Springer Science and Business Media LLC.

2022   Volume 52, Issue 9, p1350-1357

Abstract

<jats:title>Abstract</jats:title><jats:sec> <jats:title>Purpose</jats:title> Short bowel syndrome (SBS) with intestinal failure (SBS-IF) requires long-term parenteral nutrition (PN). This study investigated the real-world etiologies of SBS, treatment patterns, and PN-related outcomes among adult patients with SBS-IF in Japan. </jats:sec><jats:sec> <jats:title>Methods</jats:title> This retrospective, observational cohort study was based on data from April, 2008 to January, 2020 from one of the largest hospital-based claim databases in Japan. Analyzed patients were aged ≥ 16 years, had received continuous PN for ≥ 6 months, and had SBS or undergone SBS-related surgery with a diagnosis of a causative disease. The primary endpoint was PN weaning. </jats:sec><jats:sec> <jats:title>Results</jats:title> We analyzed data for 393 patients. The most frequent causes of SBS-IF were ileus (31.8%), Crohn's disease (20.1%), and mesenteric ischemia (16.0%). Of 144/393 (36.6%) patients who were weaned off their PN, 48 (33.3%) were subsequently restarted on PN. Of 276/393 (70.2%) patients whose PN was initiated in hospital, 156 (56.5%) transitioned to home management. The mean duration of initial PN was 450.4 and 675.5 days for patients who were able or unable to be weaned off PN, respectively. Sepsis (67.4%), catheter-related bloodstream infections (49.1%), and liver disorders (45.0%) were the most reported PN-related complications. </jats:sec><jats:sec> <jats:title>Conclusions</jats:title> Most patients with SBS-IF in Japan could not be weaned off PN and suffered life-threatening complications. </jats:sec>
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