@misc{mamoor_2022, 
  title={Elevated POLR2F expression distinguishes basal-like human breast cancer.}, 
  DOI={10.31219/osf.io/kp4t6}, 
  abstractNote={<p>Patients diagnosed with basal-like breast cancer face a more aggressive disease course and more dismal prognosis than patients diagnosed with luminal A and luminal B breast cancer molecular subtypes (1-4).  We mined published microarray data (5, 6) to understand in an unbiased fashion the most distinguishing transcriptional features of tumors from patients with basal or basal-like subtype breast cancer.  We observed transcriptome-wide differential expression of RNA polymerase II subunit F, POLR2F, when comparing tumors of patients with basal-like breast cancer with that of other PAM50 molecular subtypes.  POLR2F mRNA was present at significantly higher quantities in the tumors of patients with basal-like breast cancer.  Analysis of patient survival data revealed that POLR2F primary tumor expression was correlated with recurrence-free survival in basal subtype breast cancer.  Elevated POLR2F expression appears to distinguish basal-like human breast cancer from the other molecular subtypes.</p>}, 
  publisher={Center for Open Science}, 
  author={Mamoor, Shahan}, 
  year={2022}, 
  month={Feb}
  }