IMMUNE AGING AND SERIOUS CLINICAL IMPLICATIONS IN THE ELDERLY IN COVID-19 release_ochsy5l7e5gh5hnu3rksm55lje

Abstract

COVID-19, caused by SARS-CoV-2 infection, is mild to moderate in most healthy precedents, but can cause life-threatening illnesses or persistent debilitating symptoms in some cases. The severity of COVID-19 is related to age, with an obligation over 65 years of age, greater risk of needing intensive care. This is a descriptive, exploratory, integrative literature review, with the aim of explaining the current knowledge about the interference of the immunosenescence process in more severe conditions caused by covid-19 in the elderly. Aging is a systemic involution, including the immune system, affecting the individual with several comorbidities, including cardiac, pulmonary and neurological comorbidities that aggravate the situation of vulnerability. Aging is triggered by several mechanisms, among the most relevant are telomere reduction and oxidative stress, which in turn lead to other scenarios such as T-cell senescence, mitochondrial dysfunction and low-grade chronic inflammation, which are added to the mechanism of action of the virus that causes COVID-19, as its key-lock factor involving ACE-2, which has a change in expression during aging, portraying the interferences of this scenario, if not in contact with the major covid-19, which contributes to seriousness in the elderly .
In application/xml+jats format

Archived Files and Locations