BRCA1 promoter methylation is linked to defective homologous recombination repair and elevated miR-155 to disrupt myeloid differentiation in myeloid malignancies
release_nag2lvx64zhkhl4v7axzy7qglm
by
Weijie Poh,
Robert Dilley,
Alison Moliterno,
Jaroslaw P Maciejewski,
Keith W. Pratz,
Michael A McDevitt,
James G Herman
2019 Volume 25, Issue 8, clincanres.0179.2018
Abstract
Defective homologous recombination (HR) has been reported in multiple myeloid disorders, suggesting a shared dysregulated pathway in these diverse malignancies. Because targeting HR-defective cancers with PARP inhibition (PARPi) has yielded clinical benefit, improved understanding of HR defects is needed to implement this treatment modality.
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