BRCA1 promoter methylation is linked to defective homologous recombination repair and elevated miR-155 to disrupt myeloid differentiation in myeloid malignancies release_nag2lvx64zhkhl4v7axzy7qglm

by Weijie Poh, Robert Dilley, Alison Moliterno, Jaroslaw P Maciejewski, Keith W. Pratz, Michael A McDevitt, James G Herman

Published in Clinical Cancer Research by American Association for Cancer Research (AACR).

2019   Volume 25, Issue 8, clincanres.0179.2018

Abstract

Defective homologous recombination (HR) has been reported in multiple myeloid disorders, suggesting a shared dysregulated pathway in these diverse malignancies. Because targeting HR-defective cancers with PARP inhibition (PARPi) has yielded clinical benefit, improved understanding of HR defects is needed to implement this treatment modality.
In text/plain format

Archived Files and Locations

application/pdf   3.1 MB
file_x5tcmqzw2rctfoe7tfwyach6ou
application/pdf   809.4 kB
file_g4izcnrrmfejth6ovdk6od5kmy
clincancerres.aacrjournals.org (web)
web.archive.org (webarchive)
application/pdf   3.1 MB
file_zssguuksmng4tng2o3lklug7ie
clincancerres.aacrjournals.org (web)
web.archive.org (webarchive)
Read Archived PDF
Preserved and Accessible
Type  article-journal
Stage   published
Date   2019-01-28
Language   en ?
Container Metadata
Not in DOAJ
In Keepers Registry
ISSN-L:  1078-0432
Work Entity
access all versions, variants, and formats of this works (eg, pre-prints)
Catalog Record
Revision: c1aee506-1fd2-44e4-a657-824cb4439105
API URL: JSON