@misc{hosomi_saito_park_murakami_shibata_ando_nagatake_konishi_ohno_tanisawa_et al._2022, 
  title={Unique metabolic profiles of Blautia wexlerae achieve beneficial effects for the control of obesity and type 2 diabetes}, 
  DOI={10.21203/rs.3.rs-1259439/v1}, 
  abstractNote={<jats:title>Abstract</jats:title>
        <jats:p>The gut microbiome is an important determinant in various diseases. Here we performed a cross-sectional study of Japanese adults and identified the <jats:italic>Blautia</jats:italic> genus, especially <jats:italic>B. wexlerae</jats:italic>, as a commensal bacterium that is inversely correlated with obesity and type 2 diabetes mellitus. Oral administration of <jats:italic>B. wexlerae</jats:italic> to mice induced metabolic changes and anti-inflammatory effects that decreased both high-fat diet–induced obesity and diabetes. The beneficial effects of <jats:italic>B. wexlerae</jats:italic> were mediated directly by unique amino-acid metabolism to produce S-adenosylmethionine, acetylcholine, and l-ornithine and indirectly by carbohydrate metabolism resulting in the accumulation of amylopectin and production of succinate, lactate, and acetate and simultaneous modification of the gut bacterial composition. These findings reveal unique regulatory pathways of host and microbial metabolism that may provide novel strategies in preventive and therapeutic approaches for metabolic disorders.</jats:p>}, 
  publisher={Research Square Platform LLC}, 
  author={Hosomi, Koji and Saito, Mayu and Park, Jonguk and Murakami, Haruka and Shibata, Naoko and Ando, Masahiro and Nagatake, Takahiro and Konishi, Kana and Ohno, Harumi and Tanisawa, Kumpei and et al.}, 
  year={2022}, 
  month={Jan}
  }