Celastrol attenuates the remodeling of pulmonary vascular and right ventricular in monocrotaline-induced pulmonary arterial hypertension in rat release_m4xwedp2sba7ja3s57lyu2pl4u

Abstract

Pulmonary arterial hypertension is a progressive angio-proliferative disease associated with high morbidity and mortality rates. Although the histopathology of pulmonary arterial hypertension is well described, its therapeutic option remains unsatisfactory.It is increasing being recognized that early and persistent inflammation plays an indispensable role in the development and progression of PAH.Celastrol, isolated from the root extracts of Tripterygium wilfordii (thunder god vine), is a quinone methide triterpene. Increasing evidence suggests that celastrol exerts powerful effects on anti-inflammatory and antioxidant activities. This study investigated the effect of celastrol treatment on right ventricular dysfunction, remodeling, and pulmonary vascular remodeling in pulmonary arterial hypertension rats as well as its possible mechanisms.
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