@article{kaminski_falavigna_venturin_marinowic_bagatini_xavier_dacosta_2013, title={Two intrathecal transplants of bone marrow mononuclear cells produce motor improvement in an acute and severe model of spinal cord injury}, volume={12}, DOI={10.1590/s1808-18512013000400001}, abstractNote={OBJECTIVE: We studied transplants of bone marrow mononuclear cells (BMMC) by lumbar puncture (LP) in a severe model of spinal cord injury (SCI) using clip compression. METHODS: BMMCs or saline solution were transplanted by LP 48 hours and 9 days post injury. Motor function was evaluated by BBB scale, histological analysis by Nissl technique and the verification of cell migration by PCR analysis. RESULTS: The BBB had significantly improved in rats treated with BMMCs by LP compared with controls (p<0.001). The histological analysis did not showed difference in the lesional area between the groups. The PCR analysis was able to found BMMCs in the injury site. CONCLUSIONS: two BMMC transplants by LP improved motor function in a severe model of SCI and BMMC was found in the injury site.}, publisher={FapUNIFESP (SciELO)}, author={Kaminski and Falavigna and Venturin and Marinowic and Bagatini and Xavier and DaCosta}, year={2013} }