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Einfluß von 2-Desoxy-2.3-dehydro-N-acetylneuraminsäure auf Myxovirus-Neuraminidasen und die Replikation von Influenza- und Newcastle Disease Virus / Influence of 2-Deoxy-2,3-dehydro-N-acetylneuraminic Acid on Myxovirus-neuraminidases and the Replication of Influenza- and Newcastle Disease Virus
release_ltmgxw3vwndhtaprhfhdcdxfne
by
P. Meindl,
G. Bodo,
J. Lindner,
P. Palese
Published
in Zeitschrift für Naturforschung. B, A journal of chemical sciences
by Walter de Gruyter GmbH.
1971 Volume 26, p792-797
Abstract
Neuraminidase of Influenza-A-Melbourne virus was competitively inhibited by 2-deoxy-2,3-dehydro-N-acetylneuraminic acid. The inhibition constant (K<jats:sub>I</jats:sub>) was found to be 5.3 × 10<jats:sup>-6</jats:sup> mol/l. The inhibition of different viral neuraminidases was found to vary considerably. The release of Influenza-A-Melbourne virus adsorbed to chick erythrocytes was strongly inhibited by 2-deoxy-2,3-dehydro-N-acetylneuraminic acid. This substance also influenced the replication of neuraminidase containing viruses. The extent of this inhibition was variable. In contrast, the replication of viruses not containing neuraminidase was not affected.
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