IJSRST162331 | Comparative Formulation and Evaluation of Fast Dissolving Candesartan Tablet Using Natural Superdisintegrants release_lsd23wecvffmdjns6mqd6jb5lu

Abstract

© 2016 IJSRST | Volume 2 | Issue 3 | Print ABSTRACT Candesartan is used commonly for the treatment of hypertension. It has half-life of 9 hrs whereas T max is 3-4 hr. As Candesartan is water insoluble drug this adversely affects bioavailability and bioequivalence.In present study efforts are made to reduce its disintegrating time using Plantago ovata and Sodium starch glycolate as comparative superdisintegrnats.. The objective of the present study was to prepare the fast dissolving tablet of candesartan using different natural superdisintegrants like Plantago ovata, , Sodium Starch Glycolate,. Hardness, friability, weight variation, wetting time, thickness, water absorption ratio, disintegrating time, uniformity of content and in-vitro drug release were checked for evaluation purpose.
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