@article{cirillo_pantuso_curcio_vittorio_leggio_iemma_de filpo_nicoletta_2021, 
  title={Alginate Bioconjugate and Graphene Oxide in Multifunctional Hydrogels for Versatile Biomedical Applications}, 
  volume={26}, 
  DOI={10.3390/molecules26051355}, 
  abstractNote={<jats:p>In this work, we combined electrically-conductive graphene oxide and a sodium alginate-caffeic acid conjugate, acting as a functional element, in an acrylate hydrogel network to obtain multifunctional materials designed to perform multiple tasks in biomedical research. The hybrid material was found to be well tolerated by human fibroblast lung cells (MRC-5) (viability higher than 94%) and able to modify its swelling properties upon application of an external electric field. Release experiments performed using lysozyme as the model drug, showed a pH and electro-responsive behavior, with higher release amounts and rated in physiological vs. acidic pH. Finally, the retainment of the antioxidant properties of caffeic acid upon conjugation and polymerization processes (Trolox equivalent antioxidant capacity values of 1.77 and 1.48, respectively) was used to quench the effect of hydrogen peroxide in a hydrogel-assisted lysozyme crystallization procedure.</jats:p>}, 
  number={5}, 
  publisher={MDPI AG}, 
  author={Cirillo, Giuseppe and Pantuso, Elvira and Curcio, Manuela and Vittorio, Orazio and Leggio, Antonella and Iemma, Francesca and De Filpo, Giovanni and Nicoletta, Fiore Pasquale}, 
  year={2021}, 
  month={Mar}
  }