Histopathological Features of Time-Zero Kidney Biopsy Are Predictive Factors for Posttransplant Anemia release_j2u64kz2kbedzb64kq3ajuqp5a

by Mislav Mokos, Ivana Juric, Ivica Mokos, Marijana Coric, Zeljko Kastelan, Nikolina Basic-Jukic

Published in Kidney & Blood Pressure Research by S. Karger AG.

2023   Volume 48, p505-514

Abstract

<b><i>Introduction:</i></b> Posttransplant anemia (PTA) is a common complication of kidney transplantation, associated with reduced graft survival and higher mortality. We aimed to determine the association of PTA with histopathological characteristics of time-zero allograft biopsy and donor clinical characteristics. <b><i>Methods:</i></b> We conducted a retrospective, observational cohort study that included 587 patients who underwent kidney transplantation in our center. Hemoglobin levels were assessed at 6 and 12 months after transplantation, and anemia was defined according to World Health Organization criteria. The kidney allograft time-zero biopsy has been done in all investigated cases. The evaluated histopathological parameters of the kidney allografts included glomerulosclerosis, arteriolar hyalinosis (AH), vascular fibrous intimal thickening (CV), interstitial fibrosis, tubular atrophy, and interstitial fibrosis and tubular atrophy. The Banff Classification of Allograft Pathology criteria were followed to assess the allograft histopathological changes. <b><i>Results:</i></b> The prevalence of anemia was 31.3% at 6 months after transplantation and 23.5% at 12 months. There was an association between 20-50% glomerulosclerosis and PTA in both time points, independently from estimated glomerular filtration rate. AH and interstitial fibrosis were identified as independent risk factors for anemia 6 months after transplantation. <b><i>Conclusion:</i></b> Histopathological features of time-zero kidney biopsy may be predictors of PTA. Among them, our study recognized 20–50% degree of glomerulosclerosis, AH, and CV as the most significant risk factors for PTA.
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Type  article-journal
Stage   published
Date   2023-06-12
Language   en ?
DOI  10.1159/000530945
PubMed  37307795
PMC  PMC10413787
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