Protective effects of Mosla Chinensis Maxim against Lung Injury release_idfjce7wwvdtvdk57ngu7qj2my

by Hui-Chun Ku, Shih-Yi Lee, Yung-Kai Lin, Yung-Hsiang Lin, Chi-Fu Chiang

Published in Scholars Academic Journal of Biosciences by SASPR Edu International Pvt. Ltd.

2023   Volume 11, Issue 11, p389-396

Abstract

Lung fibrosis is a common form of interstitial lung disease. Traditional Chinese medicinal plants have the ability to suppress lung inflammation, but there are relatively few studies on the relationship between Mosla Chinensis Maxim and lung injury. The purpose of this study was to investigate whether Mosla Chinensis Maxim extract (MCME) can alleviate lung injury. This study utilized lung epithelial cells, A549, treated MCME (0.25mg/mL), and analyzed the wound-healing ability, inflammatory cytokines, and cell-cell adheren junctions (E-cadherin). Bleomycin was used to induced lung fibrosis in an animal model, which were then treated with MCME. The results showed that MCME improved cellular repair capacity by 30% compared to the mock group, inhibited IL-8 by approximately 60%, and increased the E-cadherin expression compared to the lipopolysaccharide group. In an animal model, administration of MCME (50 mg/kg) for 14 days alleviated the bleomycin-induced pathological changes in the lungs and fibrosis. This study demonstrated that MCME improved lung injury.
In application/xml+jats format

Archived Files and Locations

application/pdf   475.0 kB
file_sg7ywrm6sjeq3awifbcjeef64m
saspublishers.com (publisher)
web.archive.org (webarchive)
Read Archived PDF
Preserved and Accessible
Type  article-journal
Stage   published
Date   2023-11-24
Journal Metadata
Not in DOAJ
Not in Keepers Registry
ISSN-L:  2321-6883
Work Entity
access all versions, variants, and formats of this works (eg, pre-prints)
Catalog Record
Revision: 070b8047-c933-4205-b101-4e7d6e40ebb8
API URL: JSON