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Pharmacogenetics in anesthesiology: what to look for. Review
release_hlcofpr5lzarxlrvz3uc2zmik4
by
O. A Makharin,
V. M Genilo,
A. A Bichkov,
EVGENIY VALER'EVICh GRIGOR'EV,
PETR IVANOVICh MIRONOV
Published
in Alexander Saltanov Intensive Care Herald
by Practical Medicine Publishing House.
2020 p63-72
Abstract
Individual pharmacogenetic features of patients areactively studied in various fields of medicine and anesthesiology is no exception. The purpose of this article is to unite the available literature data of polymorphisms affecting the perioperative period. The review includes information obtained from SCOPUS, MedLine, PharmGKB. The effects of cytochrome CYP2D6 polymorphism on the metabolism of tramadol, ondansetron and codeine are described. Also the influence of μ-opioid receptor OPRM1 polimorphism on the doses of narcotic analgesics and ryanodine receptor RYR1 and calcium channels on the probability of malignant hyperthermia are described, and also considered gene polymorphisms that affect the development of anaphylactic reactions
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