@misc{aoki_tateyama_shimomura_ihara_kubo_nakano_mori_2018, title={SLO potassium channels antagonize premature decision making in C. elegans}, DOI={10.1101/243220}, abstractNote={Animals have to modify their behavior at the right timing to respond to changes in environments. Yet, the molecular and neural mechanisms regulating the timing of behavioral transition remain largely unknown. Performing forward genetics on a plasticity of thermotaxis behavior in C. elegans, we demonstrated that SLO potassium channels together with a cyclic nucleotide-gated channel CNG-3 determine the timing of the transition of temperature preference after shift of cultivation temperature. We further revealed that SLO and CNG-3 channels regulate the alteration in responsiveness of thermosensory neurons. Our results suggest that the regulation of sensory adaptation is a major determinant of the latency for animals to make decisions in changing behavior.}, publisher={Cold Spring Harbor Laboratory}, author={Aoki and Tateyama and Shimomura and Ihara and Kubo and Nakano and Mori}, year={2018}, month={Jan} }