Proteome Analyses of Staphylococcus aureus Biofilm at Elevated Levels of NaCl release_gkcf34oe65al5c5fj4gwh6hcta

by Nazrul Islam Julia M Ross, Mark R Marten

Published in Clinical Microbiology: Open Access by OMICS Publishing Group.

2015   Volume 04, Issue 05

Abstract

Our studies demonstrate that sodium chloride (NaCl) induces changes in biofilm, mediated by increased production of polysaccharides intercellular adhesion (PIA). We identified 12 proteins that showed higher abundance in increased level of NaCl. This includes one important protein (IsaA) known to be associated with biofilm stability. In addition, we also found higher abundance of a cold shock protein, CspA, at higher NaCl. We have also identified several other proteins that are differentially expressed to the elevated levels of NaCl and mapped them in the regulatory pathways of PIA. The majority of proteins are involved with various aspects bacterial metabolic function. Our results demonstrated that NaCl influences gene regulatory networks controlling exopolysaccharide expression.
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Type  article-journal
Stage   published
Date   2015-09-22
Language   en ?
DOI  10.4172/2327-5073.1000219
PubMed  26973848
PMC  PMC4786021
Wikidata  Q36672783
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