Formulation And In Vitro Evaluation Of Dalfampridine Sustained Release Tablets By Using Various Polymers release_fvpidkbrojcmlj7gi3brupp27m

Abstract

In present investigation the sustained release tablets of Dalfampridine was formulated to study effect various natural polymers of Tragacanth, Acacia gum and Xanthan gum. The model is based on a novel dosage form designed to deliver a drug into the gastrointestinal tract in a controlled manner. Matrix tablets were prepared by direct compression method. As a pre-requisite and part of pre-formulation studies, drug along with selected excipients and as optimized formulation was subjected to FT-IR studies. It was found that no interaction among excipients occurred, as no extra peaks obtained. Tablets were evaluated for various IP-QC tests like hardness, friability, content uniformity and in-vitro drug release by USP paddle apparatus. It was found that the release of drug D3 formulation showed 99.83% the formulation was gave the better release than other formulations. In these nine formulations D3 formulation was showing highest release following Peppas release kinetics.
In application/xml+jats format

Archived Files and Locations