@misc{raskar_niebling_devos_yorke_h&aumlrtlein_huse_forsyth_seydel_pearson_2020, 
  title={Diffusive dynamics of Aspartate α-decarboxylase (ADC) liganded with D-serine in aqueous solution}, 
  DOI={10.1101/2020.08.11.244939}, 
  abstractNote={<jats:p>Incoherent neutron spectroscopy, in combination with dynamic light scattering was used to investigate the effect of ligand binding on the center-of-mass self-diffusion and internal diffusive dynamics of <jats:italic>E.coli</jats:italic> aspartate α-decarboxylase (ADC). The X-ray crystal structure of the D-serine inhibitor complex with ADC was also determined, and molecular dynamics simulations used to further probe the structural rearrangements that occur as a result of ligand binding.
These experiments reveal the existence of higher order oligomers of the ADC tetramer on ns-ms time-scales, and also show that ligand binding both affects the ADC internal diffusive dynamics and appears to further increase the size of the higher order oligomers.</jats:p>}, 
  publisher={Cold Spring Harbor Laboratory}, 
  author={Raskar, Tushar and Niebling, Stephan and Devos, Juliette M. and Yorke, Briony A. and H&aumlrtlein, Michael and Huse, Nils and Forsyth, Trevor V. and Seydel, Tilo and Pearson, Arwen R.}, 
  year={2020}, 
  month={Aug}
  }